Gentamicin Induces Renal Morphopathology in Wistar Rats
Due to its prominent role in major excretory pathways, the kidney is particularly sensitive especially to toxicity for antimicrobials drugs. Storage of these drugs in the renal cortex, their effect on renal cells, have consequences on the renal function, and then reabsorbed by renal tubules induce n...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Anatomía
2009
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100011 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0717-95022009000100011 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0717-950220090001000112009-06-24Gentamicin Induces Renal Morphopathology in Wistar Ratsde Souza,Vanessa BarbozaOliveira,Rodrigo Fagundes L. deLucena,Hévio Freitas deFerreira,Aurigena A. AGuerra,Gerlane Coelho BernardoFreitas,Maria de LourdesQueiroz,Karla Cristiane de Souzade Araújo Júnior,Raimundo F Nephrotoxicity Aminoglycosides Expression of the P53 protein Renal morphopatological alterations Due to its prominent role in major excretory pathways, the kidney is particularly sensitive especially to toxicity for antimicrobials drugs. Storage of these drugs in the renal cortex, their effect on renal cells, have consequences on the renal function, and then reabsorbed by renal tubules induce nephrotixicity. Our objective was to show the renal morphopatological alterations induced by gentamicin through the histochemical methods of routine periodic acid de Schiff (PAS) staining and imunohistochemical staining for the expression of the protein P53, which is considered as a marker for cellular apoptosis. This allows the early detection of tubular lesions. The renal morphopathologic findings were cell apoptosis, basal membrane interruption, mesangial proliferation cells, decreased Bowman's space. This result clearly shows that gentamicin administration induces renal morphopatological alterations.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.1 20092009-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100011en10.4067/S0717-95022009000100011 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Nephrotoxicity Aminoglycosides Expression of the P53 protein Renal morphopatological alterations |
| spellingShingle |
Nephrotoxicity Aminoglycosides Expression of the P53 protein Renal morphopatological alterations de Souza,Vanessa Barboza Oliveira,Rodrigo Fagundes L. de Lucena,Hévio Freitas de Ferreira,Aurigena A. A Guerra,Gerlane Coelho Bernardo Freitas,Maria de Lourdes Queiroz,Karla Cristiane de Souza de Araújo Júnior,Raimundo F Gentamicin Induces Renal Morphopathology in Wistar Rats |
| description |
Due to its prominent role in major excretory pathways, the kidney is particularly sensitive especially to toxicity for antimicrobials drugs. Storage of these drugs in the renal cortex, their effect on renal cells, have consequences on the renal function, and then reabsorbed by renal tubules induce nephrotixicity. Our objective was to show the renal morphopatological alterations induced by gentamicin through the histochemical methods of routine periodic acid de Schiff (PAS) staining and imunohistochemical staining for the expression of the protein P53, which is considered as a marker for cellular apoptosis. This allows the early detection of tubular lesions. The renal morphopathologic findings were cell apoptosis, basal membrane interruption, mesangial proliferation cells, decreased Bowman's space. This result clearly shows that gentamicin administration induces renal morphopatological alterations. |
| author |
de Souza,Vanessa Barboza Oliveira,Rodrigo Fagundes L. de Lucena,Hévio Freitas de Ferreira,Aurigena A. A Guerra,Gerlane Coelho Bernardo Freitas,Maria de Lourdes Queiroz,Karla Cristiane de Souza de Araújo Júnior,Raimundo F |
| author_facet |
de Souza,Vanessa Barboza Oliveira,Rodrigo Fagundes L. de Lucena,Hévio Freitas de Ferreira,Aurigena A. A Guerra,Gerlane Coelho Bernardo Freitas,Maria de Lourdes Queiroz,Karla Cristiane de Souza de Araújo Júnior,Raimundo F |
| author_sort |
de Souza,Vanessa Barboza |
| title |
Gentamicin Induces Renal Morphopathology in Wistar Rats |
| title_short |
Gentamicin Induces Renal Morphopathology in Wistar Rats |
| title_full |
Gentamicin Induces Renal Morphopathology in Wistar Rats |
| title_fullStr |
Gentamicin Induces Renal Morphopathology in Wistar Rats |
| title_full_unstemmed |
Gentamicin Induces Renal Morphopathology in Wistar Rats |
| title_sort |
gentamicin induces renal morphopathology in wistar rats |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2009 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100011 |
| work_keys_str_mv |
AT desouzavanessabarboza gentamicininducesrenalmorphopathologyinwistarrats AT oliveirarodrigofagundeslde gentamicininducesrenalmorphopathologyinwistarrats AT lucenaheviofreitasde gentamicininducesrenalmorphopathologyinwistarrats AT ferreiraaurigenaaa gentamicininducesrenalmorphopathologyinwistarrats AT guerragerlanecoelhobernardo gentamicininducesrenalmorphopathologyinwistarrats AT freitasmariadelourdes gentamicininducesrenalmorphopathologyinwistarrats AT queirozkarlacristianedesouza gentamicininducesrenalmorphopathologyinwistarrats AT dearaujojuniorraimundof gentamicininducesrenalmorphopathologyinwistarrats |
| _version_ |
1718444645808078848 |