Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study

Physical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic...

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Autores principales:	Padulla,Susimary Aparecida Trevizan, Azoubel,Reinaldo, Bonfim,Mariana Rotta, Accioly,Marilita Falángola, Camargo Filho,José Carlos Silva, Padovani,João Armando, Brandao,Antonio Carlos, Souza,Dorotéia Rossi Silva
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Hydroxymethylglutaryl-CoA Reductase Inhibitors Exercise Cardiomyocite nuclei
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100015
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spelling	oai:scielo:S0717-950220090001000152009-06-24Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric StudyPadulla,Susimary Aparecida TrevizanAzoubel,ReinaldoBonfim,Mariana RottaAccioly,Marilita FalángolaCamargo Filho,José Carlos SilvaPadovani,João ArmandoBrandao,Antonio CarlosSouza,Dorotéia Rossi Silva Hydroxymethylglutaryl-CoA Reductase Inhibitors Exercise Cardiomyocite nuclei Physical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic physical exercise association in the morphometric parameters of cardiac cell nucleus. 40 male rats adults were divided into four groups: exercised (DE); sedentary (DS), exercised and statin use (DES); sedentary and statin use (DSS). The animals received during the whole experimental period a hiperlipidic diet added 20% of coconut oil and 1.25% of cholesterol; after 30 days of its ingestión, a blood collection was made to verify the dyslipidaemia. Simvastatin (20 mg) was taken five days a week, during eight weeks. During this period, the animals exercised 60 minutes daily in the treadmill. After the last day of the protocol, the cardiac muscle was collected and maintained in liquid nitrogen (-180°C); the cuts were stained by Hematoxilin-Eosin method, and the cardiac fibers were submitted to the nuclear morphometric analyses. The data were analyzed using descriptive analyses, paired T test, Kruskal-Wallis test and Dunn post hoc test; for all analyses, it was adopted p<0.05. It was verified that the group receiving statin presented values statistically significant in comparison to the other groups, in the tridimensional and linear variables. The exercised and statin group, the values obtained in the morphometric analyses were similar to the control group. It is suggested that statins alone can cause alterations in the nucleus of cardiac cells that can be related to apoptosis occurrence and, when exercise is practiced associated to statin administration, the effects of statin can be reduced, what can be related to beneficial adaptations of cardiac mitochondrial in response to physical exercise, turning them more resistant to apoptotic stimuli.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.1 20092009-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100015en10.4067/S0717-95022009000100015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hydroxymethylglutaryl-CoA Reductase Inhibitors Exercise Cardiomyocite nuclei
spellingShingle	Hydroxymethylglutaryl-CoA Reductase Inhibitors Exercise Cardiomyocite nuclei Padulla,Susimary Aparecida Trevizan Azoubel,Reinaldo Bonfim,Mariana Rotta Accioly,Marilita Falángola Camargo Filho,José Carlos Silva Padovani,João Armando Brandao,Antonio Carlos Souza,Dorotéia Rossi Silva Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study
description	Physical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic physical exercise association in the morphometric parameters of cardiac cell nucleus. 40 male rats adults were divided into four groups: exercised (DE); sedentary (DS), exercised and statin use (DES); sedentary and statin use (DSS). The animals received during the whole experimental period a hiperlipidic diet added 20% of coconut oil and 1.25% of cholesterol; after 30 days of its ingestión, a blood collection was made to verify the dyslipidaemia. Simvastatin (20 mg) was taken five days a week, during eight weeks. During this period, the animals exercised 60 minutes daily in the treadmill. After the last day of the protocol, the cardiac muscle was collected and maintained in liquid nitrogen (-180°C); the cuts were stained by Hematoxilin-Eosin method, and the cardiac fibers were submitted to the nuclear morphometric analyses. The data were analyzed using descriptive analyses, paired T test, Kruskal-Wallis test and Dunn post hoc test; for all analyses, it was adopted p<0.05. It was verified that the group receiving statin presented values statistically significant in comparison to the other groups, in the tridimensional and linear variables. The exercised and statin group, the values obtained in the morphometric analyses were similar to the control group. It is suggested that statins alone can cause alterations in the nucleus of cardiac cells that can be related to apoptosis occurrence and, when exercise is practiced associated to statin administration, the effects of statin can be reduced, what can be related to beneficial adaptations of cardiac mitochondrial in response to physical exercise, turning them more resistant to apoptotic stimuli.
author	Padulla,Susimary Aparecida Trevizan Azoubel,Reinaldo Bonfim,Mariana Rotta Accioly,Marilita Falángola Camargo Filho,José Carlos Silva Padovani,João Armando Brandao,Antonio Carlos Souza,Dorotéia Rossi Silva
author_facet	Padulla,Susimary Aparecida Trevizan Azoubel,Reinaldo Bonfim,Mariana Rotta Accioly,Marilita Falángola Camargo Filho,José Carlos Silva Padovani,João Armando Brandao,Antonio Carlos Souza,Dorotéia Rossi Silva
author_sort	Padulla,Susimary Aparecida Trevizan
title	Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study
title_short	Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study
title_full	Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study
title_fullStr	Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study
title_full_unstemmed	Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study
title_sort	effects of statin and aerobic physical exercise association in the cardiomyocytes of the rat: morphometric study
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100015
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Effects of Statin and Aerobic Physical Exercise Association in the Cardiomyocytes of the Rat: Morphometric Study

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