Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica in Basic Formulations of Dentifrices
The aim of this study was to evaluate some biological characteristics and toxicity of basic formulations of dentifrices containing such substances, and to compare them with two existing products in market which also contains silic in their formulations. In this way, it was evaluated some biological...
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Sociedad Chilena de Anatomía
2009
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oai:scielo:S0717-950220090001000282009-06-24Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica in Basic Formulations of DentifricesPedrazzi,ViníciusDel Ciampo,José Orestesdo Nascimento,CássioIssa,João Paulo Mardegan Silica Dentifrices Histology Wistar rats The aim of this study was to evaluate some biological characteristics and toxicity of basic formulations of dentifrices containing such substances, and to compare them with two existing products in market which also contains silic in their formulations. In this way, it was evaluated some biological parameters: weight of the animals, oral toxicity, hematological parameters, urinary analysis, and histological evaluation. The thrombocytes were also statistically at normal levels. The glutamate-pyruvate transaminase (TGP) showed normal aspect in 5 of the tested groups, as in control. Meanwhile, the oxalacetic transaminase (AST) in one group had a small increase in the control group. Regarding urine, in exception the rats of one group, the rats of the 4 other experimental groups showed leukocytosis urinary statistically higher than the control group. The histological evaluation of the animals showed that specimens from liver, stomach, kidney and submandibular gland presented normal aspects for these organs, without significant characteristics related to inflammatory infiltrates in any of the 6 samples tested in their respective groups.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.1 20092009-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100028en10.4067/S0717-95022009000100028 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Silica Dentifrices Histology Wistar rats |
| spellingShingle |
Silica Dentifrices Histology Wistar rats Pedrazzi,Vinícius Del Ciampo,José Orestes do Nascimento,Cássio Issa,João Paulo Mardegan Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica in Basic Formulations of Dentifrices |
| description |
The aim of this study was to evaluate some biological characteristics and toxicity of basic formulations of dentifrices containing such substances, and to compare them with two existing products in market which also contains silic in their formulations. In this way, it was evaluated some biological parameters: weight of the animals, oral toxicity, hematological parameters, urinary analysis, and histological evaluation. The thrombocytes were also statistically at normal levels. The glutamate-pyruvate transaminase (TGP) showed normal aspect in 5 of the tested groups, as in control. Meanwhile, the oxalacetic transaminase (AST) in one group had a small increase in the control group. Regarding urine, in exception the rats of one group, the rats of the 4 other experimental groups showed leukocytosis urinary statistically higher than the control group. The histological evaluation of the animals showed that specimens from liver, stomach, kidney and submandibular gland presented normal aspects for these organs, without significant characteristics related to inflammatory infiltrates in any of the 6 samples tested in their respective groups. |
| author |
Pedrazzi,Vinícius Del Ciampo,José Orestes do Nascimento,Cássio Issa,João Paulo Mardegan |
| author_facet |
Pedrazzi,Vinícius Del Ciampo,José Orestes do Nascimento,Cássio Issa,João Paulo Mardegan |
| author_sort |
Pedrazzi,Vinícius |
| title |
Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica in Basic Formulations of Dentifrices |
| title_short |
Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica in Basic Formulations of Dentifrices |
| title_full |
Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica in Basic Formulations of Dentifrices |
| title_fullStr |
Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica in Basic Formulations of Dentifrices |
| title_full_unstemmed |
Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica in Basic Formulations of Dentifrices |
| title_sort |
evaluation of some biological aspects of the presence of abrasive silica and thickening silica in basic formulations of dentifrices |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2009 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100028 |
| work_keys_str_mv |
AT pedrazzivinicius evaluationofsomebiologicalaspectsofthepresenceofabrasivesilicaandthickeningsilicainbasicformulationsofdentifrices AT delciampojoseorestes evaluationofsomebiologicalaspectsofthepresenceofabrasivesilicaandthickeningsilicainbasicformulationsofdentifrices AT donascimentocassio evaluationofsomebiologicalaspectsofthepresenceofabrasivesilicaandthickeningsilicainbasicformulationsofdentifrices AT issajoaopaulomardegan evaluationofsomebiologicalaspectsofthepresenceofabrasivesilicaandthickeningsilicainbasicformulationsofdentifrices |
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