Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy

Tuberculosis is the most prevalent infectious disease in the world. Granuloma formation and caseous necrosis are hallmarks of M. tuberculosis infection and they represent the protective and inflammatory reactions in the infected tissues. The molecular mechanisms that mediate granuloma necrosis are s...

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Autores principales:	Santana,Alessandra, Loureiro,Camila, Barbosa Jr,Aryon, Arruda,Sérgio
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Tuberculous pleurisy CD68+ macrophages T CD8+ cells Caseous necrosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100033
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spelling	oai:scielo:S0717-950220090001000332009-06-24Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous PleurisySantana,AlessandraLoureiro,CamilaBarbosa Jr,AryonArruda,Sérgio Tuberculous pleurisy CD68+ macrophages T CD8+ cells Caseous necrosis Tuberculosis is the most prevalent infectious disease in the world. Granuloma formation and caseous necrosis are hallmarks of M. tuberculosis infection and they represent the protective and inflammatory reactions in the infected tissues. The molecular mechanisms that mediate granuloma necrosis are still not well understood. Objectives: To immunolocalize and correlate the amounts of CD68+ macrophages and CD8+ lymphocytes to caseous necrosis extension in granulomas of tuberculous pleurisy. Methods: The study is a retrospective analysis of 30 pleural biopsies with histopathological diagnosis of chronic granulomatous pleurisy with caseous necrosis. These biopsies were classified according to necrosis intensity as minimal (N1), moderate (N2) and intense (N3). The number of granulomas was also observed and categorized as G1 (1 to 4 granulomas per section), G2 (5 to 8 granulomas per section), and G3 (more than 8 granulomas per section). Results: The means of CD68+ cells counts per mm² in N1, N2 and N3 categories of necrosis were 1,287 ± 254, 1086 ±181 and 930 ± 115 respectively. The means for CD8+ cells were 483.7 ± 396, 366.3 ± 43 and 558 ± 53 cells per mm² in N1, N2 and N3 respectively. Conclusions: There were no significant statistical correlations between necrosis extension and cell counts. In analyzed biopsies, the number of CD68+ cells was significantly higher than the number of CD8+ cells.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.1 20092009-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100033en10.4067/S0717-95022009000100033
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Tuberculous pleurisy CD68+ macrophages T CD8+ cells Caseous necrosis
spellingShingle	Tuberculous pleurisy CD68+ macrophages T CD8+ cells Caseous necrosis Santana,Alessandra Loureiro,Camila Barbosa Jr,Aryon Arruda,Sérgio Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
description	Tuberculosis is the most prevalent infectious disease in the world. Granuloma formation and caseous necrosis are hallmarks of M. tuberculosis infection and they represent the protective and inflammatory reactions in the infected tissues. The molecular mechanisms that mediate granuloma necrosis are still not well understood. Objectives: To immunolocalize and correlate the amounts of CD68+ macrophages and CD8+ lymphocytes to caseous necrosis extension in granulomas of tuberculous pleurisy. Methods: The study is a retrospective analysis of 30 pleural biopsies with histopathological diagnosis of chronic granulomatous pleurisy with caseous necrosis. These biopsies were classified according to necrosis intensity as minimal (N1), moderate (N2) and intense (N3). The number of granulomas was also observed and categorized as G1 (1 to 4 granulomas per section), G2 (5 to 8 granulomas per section), and G3 (more than 8 granulomas per section). Results: The means of CD68+ cells counts per mm² in N1, N2 and N3 categories of necrosis were 1,287 ± 254, 1086 ±181 and 930 ± 115 respectively. The means for CD8+ cells were 483.7 ± 396, 366.3 ± 43 and 558 ± 53 cells per mm² in N1, N2 and N3 respectively. Conclusions: There were no significant statistical correlations between necrosis extension and cell counts. In analyzed biopsies, the number of CD68+ cells was significantly higher than the number of CD8+ cells.
author	Santana,Alessandra Loureiro,Camila Barbosa Jr,Aryon Arruda,Sérgio
author_facet	Santana,Alessandra Loureiro,Camila Barbosa Jr,Aryon Arruda,Sérgio
author_sort	Santana,Alessandra
title	Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_short	Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_full	Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_fullStr	Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_full_unstemmed	Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_sort	morphological analyses of caseous necrosis correlated to cd68+ and cd8+ cells in biopsies of tuberculous pleurisy
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100033
work_keys_str_mv	AT santanaalessandra morphologicalanalysesofcaseousnecrosiscorrelatedtocd68andcd8cellsinbiopsiesoftuberculouspleurisy AT loureirocamila morphologicalanalysesofcaseousnecrosiscorrelatedtocd68andcd8cellsinbiopsiesoftuberculouspleurisy AT barbosajraryon morphologicalanalysesofcaseousnecrosiscorrelatedtocd68andcd8cellsinbiopsiesoftuberculouspleurisy AT arrudasergio morphologicalanalysesofcaseousnecrosiscorrelatedtocd68andcd8cellsinbiopsiesoftuberculouspleurisy
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Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy

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