Toxicity of Sucralose in Humans: A Review

Sucralose is a non-nutritive artificial sweetener, 600 times sweeter than sucrose, and is very stable at high temperatures, among other characteristics. It was approved by the FDA, in 1999, to be utilized in foods, beverages, pharmaceutical products, diets and vitamin supplements. Studies suggest a...

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Autores principales:	Rodero,Ademir Barianni, Rodero,Lucas de Souza, Azoubel,Reinaldo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Sucralose Sweetener Toxicology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100040
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spelling	oai:scielo:S0717-950220090001000402009-06-24Toxicity of Sucralose in Humans: A ReviewRodero,Ademir BarianniRodero,Lucas de SouzaAzoubel,Reinaldo Sucralose Sweetener Toxicology Sucralose is a non-nutritive artificial sweetener, 600 times sweeter than sucrose, and is very stable at high temperatures, among other characteristics. It was approved by the FDA, in 1999, to be utilized in foods, beverages, pharmaceutical products, diets and vitamin supplements. Studies suggest a diffusion, through the placental barrier, of small doses of sucralose and its metabolites. Its hydrolysis products (4-CG e 1,6-DCF) are more rapidly absorbed than sucralose: 4-CG is excreted intact in the urine, and 1,6-DCF undergoes reduction with elimination by the urine or rapid conjugation with glutathione. Various organs can be affected by ingestión of high doses of sucralose. As a result of the rise in global consumption of sweeteners and light- or diet-type products, studies are necessary to evaluate the action of this substance in the human species. The present study aims to accomplish a review of the literature that involves its indications of use, pharmacodynamics as well as the carcinogenic, teratogenic, neurotoxic, and nephrotoxic potentials of sucralose.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.1 20092009-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100040en10.4067/S0717-95022009000100040
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sucralose Sweetener Toxicology
spellingShingle	Sucralose Sweetener Toxicology Rodero,Ademir Barianni Rodero,Lucas de Souza Azoubel,Reinaldo Toxicity of Sucralose in Humans: A Review
description	Sucralose is a non-nutritive artificial sweetener, 600 times sweeter than sucrose, and is very stable at high temperatures, among other characteristics. It was approved by the FDA, in 1999, to be utilized in foods, beverages, pharmaceutical products, diets and vitamin supplements. Studies suggest a diffusion, through the placental barrier, of small doses of sucralose and its metabolites. Its hydrolysis products (4-CG e 1,6-DCF) are more rapidly absorbed than sucralose: 4-CG is excreted intact in the urine, and 1,6-DCF undergoes reduction with elimination by the urine or rapid conjugation with glutathione. Various organs can be affected by ingestión of high doses of sucralose. As a result of the rise in global consumption of sweeteners and light- or diet-type products, studies are necessary to evaluate the action of this substance in the human species. The present study aims to accomplish a review of the literature that involves its indications of use, pharmacodynamics as well as the carcinogenic, teratogenic, neurotoxic, and nephrotoxic potentials of sucralose.
author	Rodero,Ademir Barianni Rodero,Lucas de Souza Azoubel,Reinaldo
author_facet	Rodero,Ademir Barianni Rodero,Lucas de Souza Azoubel,Reinaldo
author_sort	Rodero,Ademir Barianni
title	Toxicity of Sucralose in Humans: A Review
title_short	Toxicity of Sucralose in Humans: A Review
title_full	Toxicity of Sucralose in Humans: A Review
title_fullStr	Toxicity of Sucralose in Humans: A Review
title_full_unstemmed	Toxicity of Sucralose in Humans: A Review
title_sort	toxicity of sucralose in humans: a review
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100040
work_keys_str_mv	AT roderoademirbarianni toxicityofsucraloseinhumansareview AT roderolucasdesouza toxicityofsucraloseinhumansareview AT azoubelreinaldo toxicityofsucraloseinhumansareview
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Toxicity of Sucralose in Humans: A Review

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