Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment

Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated the putative protective effects of melatonin treatment on pancreatic I/R injury. Sprague Dawley male rats we...

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Autores principales:	Yildirim,Ayse , Tuncer,Mehmet Cudi, Pamukçu,Özlem , Aktas ,Ayfer , Akkus,Murat
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Pancreas ß cells Melatonin Ischemia Reperfusion
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000200036
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spelling	oai:scielo:S0717-950220090002000362009-09-10Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin TreatmentYildirim,Ayse Tuncer,Mehmet CudiPamukçu,Özlem Aktas ,Ayfer Akkus,Murat Pancreas ß cells Melatonin Ischemia Reperfusion Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated the putative protective effects of melatonin treatment on pancreatic I/R injury. Sprague Dawley male rats were subjected to 30 min of pancreatic pedicle occlusion followed by 90 min reperfusion. Melatonin (10 mg/kg. s.c) was administrated 30 min prior to ischemia or I/R application. At the end of the reperfusion periods, rats were decapitated. Pancreatic samples were taken for transmission electron microscopy. The results indicated that ischemia created b cell damage as evidenced by dilatation between the nucleus inner and outer membrane and degeneration on islets of Langerhans cells, was reversed by melatonin treatment. As melatonin administration reversed these microscopic damage, it seems likely that melatonin protects pancreatic tissue against oxidative damage.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.2 20092009-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000200036en10.4067/S0717-95022009000200036
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Pancreas ß cells Melatonin Ischemia Reperfusion
spellingShingle	Pancreas ß cells Melatonin Ischemia Reperfusion Yildirim,Ayse Tuncer,Mehmet Cudi Pamukçu,Özlem Aktas ,Ayfer Akkus,Murat Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment
description	Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated the putative protective effects of melatonin treatment on pancreatic I/R injury. Sprague Dawley male rats were subjected to 30 min of pancreatic pedicle occlusion followed by 90 min reperfusion. Melatonin (10 mg/kg. s.c) was administrated 30 min prior to ischemia or I/R application. At the end of the reperfusion periods, rats were decapitated. Pancreatic samples were taken for transmission electron microscopy. The results indicated that ischemia created b cell damage as evidenced by dilatation between the nucleus inner and outer membrane and degeneration on islets of Langerhans cells, was reversed by melatonin treatment. As melatonin administration reversed these microscopic damage, it seems likely that melatonin protects pancreatic tissue against oxidative damage.
author	Yildirim,Ayse Tuncer,Mehmet Cudi Pamukçu,Özlem Aktas ,Ayfer Akkus,Murat
author_facet	Yildirim,Ayse Tuncer,Mehmet Cudi Pamukçu,Özlem Aktas ,Ayfer Akkus,Murat
author_sort	Yildirim,Ayse
title	Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment
title_short	Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment
title_full	Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment
title_fullStr	Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment
title_full_unstemmed	Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment
title_sort	effects of ischemia/reperfusion on ß cells of pancreas and protective effects of melatonin treatment
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000200036
work_keys_str_mv	AT yildirimayse effectsofischemiareperfusiononßcellsofpancreasandprotectiveeffectsofmelatonintreatment AT tuncermehmetcudi effectsofischemiareperfusiononßcellsofpancreasandprotectiveeffectsofmelatonintreatment AT pamukcuozlem effectsofischemiareperfusiononßcellsofpancreasandprotectiveeffectsofmelatonintreatment AT aktasayfer effectsofischemiareperfusiononßcellsofpancreasandprotectiveeffectsofmelatonintreatment AT akkusmurat effectsofischemiareperfusiononßcellsofpancreasandprotectiveeffectsofmelatonintreatment
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Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment

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