Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

This study was undertaken to evaluate the relationship and effects of diabetes on liver morphology, architecture and function. The hepatic effects of diabetes were evaluated in vivo using streptozotocin (STZ)-induced diabetic rats as an experimental model. The degree of hepatic dysfunction was measu...

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Autores principales:	Zafar,Muhammad, Naeem-ul-Hassan Naqvi,Syed, Ahmed,Masood, Kaimkhani,Zahid Ali
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Streptozotocin Aminotransferases Alkaline phosphatase Pseudocholinesterase STZ-diabetes Hepatic injury
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300015
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spelling	oai:scielo:S0717-950220090003000152010-04-05Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic RatsZafar,MuhammadNaeem-ul-Hassan Naqvi,SyedAhmed,MasoodKaimkhani,Zahid Ali Streptozotocin Aminotransferases Alkaline phosphatase Pseudocholinesterase STZ-diabetes Hepatic injury This study was undertaken to evaluate the relationship and effects of diabetes on liver morphology, architecture and function. The hepatic effects of diabetes were evaluated in vivo using streptozotocin (STZ)-induced diabetic rats as an experimental model. The degree of hepatic dysfunction was measured by using biochemical parameters like serum transaminases (ALT and AST), alkaline phosphatase (ALP)and pseudocholinesterase (PChE) while the histopathological studies were carried out to support the enzymic Parameters. The aim of the study was to investigate the association between diabetic hepatic complications and liver enzyme alterations. This study was performed in the Department of Anatomy; Institute of Pharmaceutical Sciences and Institute of Diabetology and endocrinology of Baqai Medical University, Karachi. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty albino rats were divided into five groups: control (A) and STZ treated (B, C, D, and E) which were sacrificed 2, 4, 6 and 8 weeks post treatment respectively. Histopathological examination of liver showed accumulation of lipid droplets, lymphocytic infiltration, increased fibrous content, dilatation and congestion of portal vessels and proliferation of bile ducts. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP and PChE were observed in the liver. It seems that the diabetic complications in the liver like hepatocyte destruction etc. are likely to be due to alterations in enzyme levels.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.3 20092009-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300015en10.4067/S0717-95022009000300015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Streptozotocin Aminotransferases Alkaline phosphatase Pseudocholinesterase STZ-diabetes Hepatic injury
spellingShingle	Streptozotocin Aminotransferases Alkaline phosphatase Pseudocholinesterase STZ-diabetes Hepatic injury Zafar,Muhammad Naeem-ul-Hassan Naqvi,Syed Ahmed,Masood Kaimkhani,Zahid Ali Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
description	This study was undertaken to evaluate the relationship and effects of diabetes on liver morphology, architecture and function. The hepatic effects of diabetes were evaluated in vivo using streptozotocin (STZ)-induced diabetic rats as an experimental model. The degree of hepatic dysfunction was measured by using biochemical parameters like serum transaminases (ALT and AST), alkaline phosphatase (ALP)and pseudocholinesterase (PChE) while the histopathological studies were carried out to support the enzymic Parameters. The aim of the study was to investigate the association between diabetic hepatic complications and liver enzyme alterations. This study was performed in the Department of Anatomy; Institute of Pharmaceutical Sciences and Institute of Diabetology and endocrinology of Baqai Medical University, Karachi. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty albino rats were divided into five groups: control (A) and STZ treated (B, C, D, and E) which were sacrificed 2, 4, 6 and 8 weeks post treatment respectively. Histopathological examination of liver showed accumulation of lipid droplets, lymphocytic infiltration, increased fibrous content, dilatation and congestion of portal vessels and proliferation of bile ducts. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP and PChE were observed in the liver. It seems that the diabetic complications in the liver like hepatocyte destruction etc. are likely to be due to alterations in enzyme levels.
author	Zafar,Muhammad Naeem-ul-Hassan Naqvi,Syed Ahmed,Masood Kaimkhani,Zahid Ali
author_facet	Zafar,Muhammad Naeem-ul-Hassan Naqvi,Syed Ahmed,Masood Kaimkhani,Zahid Ali
author_sort	Zafar,Muhammad
title	Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_short	Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_full	Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_fullStr	Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_full_unstemmed	Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_sort	altered liver morphology and enzymes in streptozotocin induced diabetic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300015
work_keys_str_mv	AT zafarmuhammad alteredlivermorphologyandenzymesinstreptozotocininduceddiabeticrats AT naeemulhassannaqvisyed alteredlivermorphologyandenzymesinstreptozotocininduceddiabeticrats AT ahmedmasood alteredlivermorphologyandenzymesinstreptozotocininduceddiabeticrats AT kaimkhanizahidali alteredlivermorphologyandenzymesinstreptozotocininduceddiabeticrats
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Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

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