Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract

Cadmium (Cd), is an environmental and industrial pollutant that affects the male reproductive system. Cd induces its effect by affecting tissue antioxidant enzyme systems. Green tea extract (GTE) is an antioxidant and free radicals scavenger and has a chelating property. The purpose of this study wa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	El-Shahat,Abd El-Rahman, Gabr,Attia, Meki,Abdel-Raheim, Mehana,El-Saed
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Rat Testes Cadmium toxicity Green tea extract Lipid peroxides Glutathione
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300020
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022009000300020
record_format	dspace
spelling	oai:scielo:S0717-950220090003000202010-04-05Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea ExtractEl-Shahat,Abd El-RahmanGabr,AttiaMeki,Abdel-RaheimMehana,El-Saed Rat Testes Cadmium toxicity Green tea extract Lipid peroxides Glutathione Cadmium (Cd), is an environmental and industrial pollutant that affects the male reproductive system. Cd induces its effect by affecting tissue antioxidant enzyme systems. Green tea extract (GTE) is an antioxidant and free radicals scavenger and has a chelating property. The purpose of this study was to investigate the protective effect of GTE against testes damage induced by Cd. Four groups of male rats, were utilized as following: Controls, GTE treated, Cd treated and Cd + GTE, treated rats at the same doses. The rats received GTE and or Cd orally in drinking water. After 5 weeks, the animals were sacrificed and testes were removed for microscopic and Biochemical evaluation. The levels of lipid peroxides (LPO) and glutathione (GSH) were detected in the tissue homogenates of rat testes. The current study showed marked morphological changes in the form of swelling, congestion, hemorrhage and necrosis in testes of rats treated with Cd alone. However, the rats treated with Cd+GTE showed milder edema, congestion and minute foci of necrosis in the testes. The LPO levels were significantly higher as compared to control and of GSH were significantly lower in Cd-treated rats but when GTE was co-administrated with Cd, there was an effective reduction in oxidative stress as shown by a significant rise of GSH level. In conclusion, the rats received GTE + Cd could enhance antioxidant/ detoxification system which consequently reduced the oxidative stress in rat testes. The beneficial effect of GTE is thus potentially reducing Cd toxicity and tissue damage.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.3 20092009-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300020en10.4067/S0717-95022009000300020
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Rat Testes Cadmium toxicity Green tea extract Lipid peroxides Glutathione
spellingShingle	Rat Testes Cadmium toxicity Green tea extract Lipid peroxides Glutathione El-Shahat,Abd El-Rahman Gabr,Attia Meki,Abdel-Raheim Mehana,El-Saed Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract
description	Cadmium (Cd), is an environmental and industrial pollutant that affects the male reproductive system. Cd induces its effect by affecting tissue antioxidant enzyme systems. Green tea extract (GTE) is an antioxidant and free radicals scavenger and has a chelating property. The purpose of this study was to investigate the protective effect of GTE against testes damage induced by Cd. Four groups of male rats, were utilized as following: Controls, GTE treated, Cd treated and Cd + GTE, treated rats at the same doses. The rats received GTE and or Cd orally in drinking water. After 5 weeks, the animals were sacrificed and testes were removed for microscopic and Biochemical evaluation. The levels of lipid peroxides (LPO) and glutathione (GSH) were detected in the tissue homogenates of rat testes. The current study showed marked morphological changes in the form of swelling, congestion, hemorrhage and necrosis in testes of rats treated with Cd alone. However, the rats treated with Cd+GTE showed milder edema, congestion and minute foci of necrosis in the testes. The LPO levels were significantly higher as compared to control and of GSH were significantly lower in Cd-treated rats but when GTE was co-administrated with Cd, there was an effective reduction in oxidative stress as shown by a significant rise of GSH level. In conclusion, the rats received GTE + Cd could enhance antioxidant/ detoxification system which consequently reduced the oxidative stress in rat testes. The beneficial effect of GTE is thus potentially reducing Cd toxicity and tissue damage.
author	El-Shahat,Abd El-Rahman Gabr,Attia Meki,Abdel-Raheim Mehana,El-Saed
author_facet	El-Shahat,Abd El-Rahman Gabr,Attia Meki,Abdel-Raheim Mehana,El-Saed
author_sort	El-Shahat,Abd El-Rahman
title	Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract
title_short	Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract
title_full	Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract
title_fullStr	Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract
title_full_unstemmed	Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract
title_sort	altered testicular morphology and oxidative stress induced by cadmium in experimental rats and protective effect of simultaneous green tea extract
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300020
work_keys_str_mv	AT elshahatabdelrahman alteredtesticularmorphologyandoxidativestressinducedbycadmiuminexperimentalratsandprotectiveeffectofsimultaneousgreenteaextract AT gabrattia alteredtesticularmorphologyandoxidativestressinducedbycadmiuminexperimentalratsandprotectiveeffectofsimultaneousgreenteaextract AT mekiabdelraheim alteredtesticularmorphologyandoxidativestressinducedbycadmiuminexperimentalratsandprotectiveeffectofsimultaneousgreenteaextract AT mehanaelsaed alteredtesticularmorphologyandoxidativestressinducedbycadmiuminexperimentalratsandprotectiveeffectofsimultaneousgreenteaextract
_version_	1718444663794302976

Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract

Ejemplares similares