Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

We studied the effects of streptozotocin (STZ)-induced diabetes on kidney morphology, anatomy, architecture and on the activities of aminotransferases (AST and ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) in albino rats. The aim of the study was to investigate the association bet...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zafar,Muhammad, Naeem-ul-Hassan Naqvi,Syed, Ahmed,Masood, Kaimkhani,Zahid Ali
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Streptozotocin Aminotransferases Alkaline phosphatase Pseudocholinesterase STZ-diabetes Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300024
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022009000300024
record_format	dspace
spelling	oai:scielo:S0717-950220090003000242010-04-05Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic RatsZafar,MuhammadNaeem-ul-Hassan Naqvi,SyedAhmed,MasoodKaimkhani,Zahid Ali Streptozotocin Aminotransferases Alkaline phosphatase Pseudocholinesterase STZ-diabetes Rats We studied the effects of streptozotocin (STZ)-induced diabetes on kidney morphology, anatomy, architecture and on the activities of aminotransferases (AST and ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) in albino rats. The aim of the study was to investigate the association between diabetic kidney complications and kidney enzyme alterations. This study was performed in the Department of Anatomy and Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi and Pathology department of College of Physicians & Surgeons (CPSP) Pakistan in 2007-08. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty (80) albino rats were divided into five groups: control (A) and STZ treated (B, C, D, and E) which were sacrificed 2, 4, 6 and 8 weeks post treatment respectively. Histopathology of kidney showed lesions similar to human glomerulosclerosis, glomerular membrane thickening, arteriolar hyalinization and tubular necrosis. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) were observed in the kidney. It seems that the diabetic complications in the kidney are likely to be associated with alterations in enzyme levels.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.3 20092009-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300024en10.4067/S0717-95022009000300024
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Streptozotocin Aminotransferases Alkaline phosphatase Pseudocholinesterase STZ-diabetes Rats
spellingShingle	Streptozotocin Aminotransferases Alkaline phosphatase Pseudocholinesterase STZ-diabetes Rats Zafar,Muhammad Naeem-ul-Hassan Naqvi,Syed Ahmed,Masood Kaimkhani,Zahid Ali Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
description	We studied the effects of streptozotocin (STZ)-induced diabetes on kidney morphology, anatomy, architecture and on the activities of aminotransferases (AST and ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) in albino rats. The aim of the study was to investigate the association between diabetic kidney complications and kidney enzyme alterations. This study was performed in the Department of Anatomy and Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi and Pathology department of College of Physicians & Surgeons (CPSP) Pakistan in 2007-08. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty (80) albino rats were divided into five groups: control (A) and STZ treated (B, C, D, and E) which were sacrificed 2, 4, 6 and 8 weeks post treatment respectively. Histopathology of kidney showed lesions similar to human glomerulosclerosis, glomerular membrane thickening, arteriolar hyalinization and tubular necrosis. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) were observed in the kidney. It seems that the diabetic complications in the kidney are likely to be associated with alterations in enzyme levels.
author	Zafar,Muhammad Naeem-ul-Hassan Naqvi,Syed Ahmed,Masood Kaimkhani,Zahid Ali
author_facet	Zafar,Muhammad Naeem-ul-Hassan Naqvi,Syed Ahmed,Masood Kaimkhani,Zahid Ali
author_sort	Zafar,Muhammad
title	Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_short	Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_full	Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_fullStr	Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_full_unstemmed	Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats
title_sort	altered kidney morphology and enzymes in streptozotocin induced diabetic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300024
work_keys_str_mv	AT zafarmuhammad alteredkidneymorphologyandenzymesinstreptozotocininduceddiabeticrats AT naeemulhassannaqvisyed alteredkidneymorphologyandenzymesinstreptozotocininduceddiabeticrats AT ahmedmasood alteredkidneymorphologyandenzymesinstreptozotocininduceddiabeticrats AT kaimkhanizahidali alteredkidneymorphologyandenzymesinstreptozotocininduceddiabeticrats
_version_	1718444664542986240

Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

Ejemplares similares