In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive

The intra-buccal polymeric bioadhesive systems that can stay adhered to the oral soft tissues for drug programmed release, with the preventive and/or therapeutic purpose has been employed for large clinical situations. A system based on hydroxypropyl methyl cellulose/Carbopol 934'/magnesium ste...

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Autores principales:	Pedrazzi,Vinícius, Lara,Elza Helena Guimarães, Panzeri,Heitor, Collett,John H, Issa,João Paulo Mardegan
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Drug delivery systems Oral delivery Mucin Oral mucosa Fluoride
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300026
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spelling	oai:scielo:S0717-950220090003000262010-04-05In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal BioadhesivePedrazzi,ViníciusLara,Elza Helena GuimarãesPanzeri,HeitorCollett,John HIssa,João Paulo Mardegan Drug delivery systems Oral delivery Mucin Oral mucosa Fluoride The intra-buccal polymeric bioadhesive systems that can stay adhered to the oral soft tissues for drug programmed release, with the preventive and/or therapeutic purpose has been employed for large clinical situations. A system based on hydroxypropyl methyl cellulose/Carbopol 934'/magnesium stearate (HPMC/Cp/StMg) was developed having the sodium fluoride as active principle. This kind of system was evaluated according to its resistance to the removal by means of physical test of tensile strength. Swine buccal mucosa extracted immediately after animals' sacrifice was employed as substrate for the physical trials, to obtain 16 test bodies. Artificial saliva with or without mucin was used to involve the substrate/bioadhesive system sets during the trials. Artificial salivas viscosity was determined by means of Brookfield viscometer, showing the artificial saliva with mucin 10.0 cP, and the artificial saliva without mucin 7.5 cP. The tensile strength assays showed the following averages: for the group "artificial saliva with mucin" - 12.89 Pa, and for the group "without mucin" - 12.35 Pa. Statistical analysis showed no significant difference between the assays for both artificial salivas, and it was possible to conclude that the variable mucin did not interfered with the bioadhesion process for the polymeric devices. The device was able to release fluoride in a safe, efficient and constant way up to 8 hours.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.3 20092009-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300026en10.4067/S0717-95022009000300026
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Drug delivery systems Oral delivery Mucin Oral mucosa Fluoride
spellingShingle	Drug delivery systems Oral delivery Mucin Oral mucosa Fluoride Pedrazzi,Vinícius Lara,Elza Helena Guimarães Panzeri,Heitor Collett,John H Issa,João Paulo Mardegan In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive
description	The intra-buccal polymeric bioadhesive systems that can stay adhered to the oral soft tissues for drug programmed release, with the preventive and/or therapeutic purpose has been employed for large clinical situations. A system based on hydroxypropyl methyl cellulose/Carbopol 934'/magnesium stearate (HPMC/Cp/StMg) was developed having the sodium fluoride as active principle. This kind of system was evaluated according to its resistance to the removal by means of physical test of tensile strength. Swine buccal mucosa extracted immediately after animals' sacrifice was employed as substrate for the physical trials, to obtain 16 test bodies. Artificial saliva with or without mucin was used to involve the substrate/bioadhesive system sets during the trials. Artificial salivas viscosity was determined by means of Brookfield viscometer, showing the artificial saliva with mucin 10.0 cP, and the artificial saliva without mucin 7.5 cP. The tensile strength assays showed the following averages: for the group "artificial saliva with mucin" - 12.89 Pa, and for the group "without mucin" - 12.35 Pa. Statistical analysis showed no significant difference between the assays for both artificial salivas, and it was possible to conclude that the variable mucin did not interfered with the bioadhesion process for the polymeric devices. The device was able to release fluoride in a safe, efficient and constant way up to 8 hours.
author	Pedrazzi,Vinícius Lara,Elza Helena Guimarães Panzeri,Heitor Collett,John H Issa,João Paulo Mardegan
author_facet	Pedrazzi,Vinícius Lara,Elza Helena Guimarães Panzeri,Heitor Collett,John H Issa,João Paulo Mardegan
author_sort	Pedrazzi,Vinícius
title	In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive
title_short	In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive
title_full	In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive
title_fullStr	In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive
title_full_unstemmed	In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive
title_sort	in vitro fluoride release and tensile bond strength of a polymeric intra-buccal bioadhesive
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300026
work_keys_str_mv	AT pedrazzivinicius invitrofluoridereleaseandtensilebondstrengthofapolymericintrabuccalbioadhesive AT laraelzahelenaguimaraes invitrofluoridereleaseandtensilebondstrengthofapolymericintrabuccalbioadhesive AT panzeriheitor invitrofluoridereleaseandtensilebondstrengthofapolymericintrabuccalbioadhesive AT collettjohnh invitrofluoridereleaseandtensilebondstrengthofapolymericintrabuccalbioadhesive AT issajoaopaulomardegan invitrofluoridereleaseandtensilebondstrengthofapolymericintrabuccalbioadhesive
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In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive

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