Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine

The TMJ has been to the Dental community a key point in the search of knowledge, being it part of the temporomandibular joint complex and of the estomatognathic system which are in charge of the mastication, speech, swallowing, as well as participation in breathing and taste perception. For the majo...

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Autores principales:	Cavalcanti,Ully Dias Nascimento Távora, Baratella Evêncio,Liriane, Evêncio Neto,Joaquim, Castro,Raul Manhães de, Cardona,Aryana Soares, Melo,Marina Lins Maymone de, Lins,Rafael Claudino
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	TMJ Mandibular condyle Serotonin Fluoxetine Development
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300041
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spelling	oai:scielo:S0717-950220090003000412010-04-05Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With FluoxetineCavalcanti,Ully Dias Nascimento TávoraBaratella Evêncio,LirianeEvêncio Neto,JoaquimCastro,Raul Manhães deCardona,Aryana SoaresMelo,Marina Lins Maymone deLins,Rafael Claudino TMJ Mandibular condyle Serotonin Fluoxetine Development The TMJ has been to the Dental community a key point in the search of knowledge, being it part of the temporomandibular joint complex and of the estomatognathic system which are in charge of the mastication, speech, swallowing, as well as participation in breathing and taste perception. For the majority of the women in serious state of depression, which do not respond psychotherapeutic treatment, pharmacological treatment it's applied. The antidepressants serotonin selective reuptake inhibitors (SSRIs) are the most recommended in these cases. The teratogenic effect of the SSRIs is considered controversial, studies done with women who used these drugs during the pregnancy showed that the respiratory and central nervous systems are the most affected, was also recorded a deficit of body growth and the decrease of the encephalon and skull measures. In the present study, our goal was to assess whether the administration of Fluoxetine during the pregnancy modified the embryology and morphology of the TMJ of rats. For that, 16 Wistar female rats from the Nutrition Department of the UFPE vivarium were selected; 8 for the control group, which received daily 0.9% of saline in subcutaneous dose of 10ml/g, with schedules previously established after daily weighing and 8 for the experimental one that were treated with fluoxetine hydrochloride with the dose of 10mg/Kg in a volume 10ml/g of weight, were injected subcutaneously with the same standards established for the control group. It was observed, with this dose that the embryological development of the TMJ, especially of the mandibular condyle, does not present any difference between the degree of maturation of the tissue that forms the TMJ, especially of the condyle between the treated and control groups.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.3 20092009-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300041en10.4067/S0717-95022009000300041
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	TMJ Mandibular condyle Serotonin Fluoxetine Development
spellingShingle	TMJ Mandibular condyle Serotonin Fluoxetine Development Cavalcanti,Ully Dias Nascimento Távora Baratella Evêncio,Liriane Evêncio Neto,Joaquim Castro,Raul Manhães de Cardona,Aryana Soares Melo,Marina Lins Maymone de Lins,Rafael Claudino Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine
description	The TMJ has been to the Dental community a key point in the search of knowledge, being it part of the temporomandibular joint complex and of the estomatognathic system which are in charge of the mastication, speech, swallowing, as well as participation in breathing and taste perception. For the majority of the women in serious state of depression, which do not respond psychotherapeutic treatment, pharmacological treatment it's applied. The antidepressants serotonin selective reuptake inhibitors (SSRIs) are the most recommended in these cases. The teratogenic effect of the SSRIs is considered controversial, studies done with women who used these drugs during the pregnancy showed that the respiratory and central nervous systems are the most affected, was also recorded a deficit of body growth and the decrease of the encephalon and skull measures. In the present study, our goal was to assess whether the administration of Fluoxetine during the pregnancy modified the embryology and morphology of the TMJ of rats. For that, 16 Wistar female rats from the Nutrition Department of the UFPE vivarium were selected; 8 for the control group, which received daily 0.9% of saline in subcutaneous dose of 10ml/g, with schedules previously established after daily weighing and 8 for the experimental one that were treated with fluoxetine hydrochloride with the dose of 10mg/Kg in a volume 10ml/g of weight, were injected subcutaneously with the same standards established for the control group. It was observed, with this dose that the embryological development of the TMJ, especially of the mandibular condyle, does not present any difference between the degree of maturation of the tissue that forms the TMJ, especially of the condyle between the treated and control groups.
author	Cavalcanti,Ully Dias Nascimento Távora Baratella Evêncio,Liriane Evêncio Neto,Joaquim Castro,Raul Manhães de Cardona,Aryana Soares Melo,Marina Lins Maymone de Lins,Rafael Claudino
author_facet	Cavalcanti,Ully Dias Nascimento Távora Baratella Evêncio,Liriane Evêncio Neto,Joaquim Castro,Raul Manhães de Cardona,Aryana Soares Melo,Marina Lins Maymone de Lins,Rafael Claudino
author_sort	Cavalcanti,Ully Dias Nascimento Távora
title	Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine
title_short	Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine
title_full	Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine
title_fullStr	Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine
title_full_unstemmed	Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine
title_sort	morphological aspects of the embryonic development of the tmj in rats (rattus norvegicus albinus) treated with fluoxetine
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300041
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Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine

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