Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice

Modul8® is a composite mixture of natural products that are known to be an immunomodulator. In the current study the effect of this immunomodulator is tested on an experimental asthmatic BALB/c mouse model to investigate its properties on the white blood cell count in the blood and bronchial lavage...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Oberholzer,Hester Magdalena, Vieira,Warren Antonio, Pretorius,Etheresia
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Modul8® Asthma BALB/c mouse model White blood cells Fibrin and platelet ultrastructure
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300049
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022009000300049
record_format	dspace
spelling	oai:scielo:S0717-950220090003000492010-04-05Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c MiceOberholzer,Hester MagdalenaVieira,Warren AntonioPretorius,Etheresia Modul8® Asthma BALB/c mouse model White blood cells Fibrin and platelet ultrastructure Modul8® is a composite mixture of natural products that are known to be an immunomodulator. In the current study the effect of this immunomodulator is tested on an experimental asthmatic BALB/c mouse model to investigate its properties on the white blood cell count in the blood and bronchial lavage of the animals since white blood cells play a fundamental role in the inflammatory process involved in asthma. As it is known that platelets also play an important role in the immune system, the ultrastructure of platelets and fibrin networks were also investigated by scanning electron microscopy. The animals were sensitised, nebulized and treated over a period of 43 days until termination. Results from the blood smears as well as the bronchial lavage smears revealed significantly higher eosinophil counts in the asthmatic group compared to the control and treated groups. Changes in the ultrastructure of the platelets and fibrin networks could also be observed, with the Modul8® -treated group appearing similar to that of the control group where thick major and thin minor fibres could clearly be distinguished and a tight mass of platelet aggregate could be observed. Whereas the fibrin networks from the asthmatic animals appeared flimsy with a tight mass of thin fibres covering the thick major fibres. The asthmatic platelet aggregates appeared granular without the tight round appearance of the control platelet aggregates. It is therefore concluded that Modul8® positively influences the white blood cell counts by altering the asthmatic profile to look similar to that of the control. Also, it seems as if Modul8® has a stabilizing effect on the platelets and fibrin networks. From these results it can be suggested that Modul8® might successfully be used in the treatment of inflammatory conditions such as asthma.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.3 20092009-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300049en10.4067/S0717-95022009000300049
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Modul8® Asthma BALB/c mouse model White blood cells Fibrin and platelet ultrastructure
spellingShingle	Modul8® Asthma BALB/c mouse model White blood cells Fibrin and platelet ultrastructure Oberholzer,Hester Magdalena Vieira,Warren Antonio Pretorius,Etheresia Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice
description	Modul8® is a composite mixture of natural products that are known to be an immunomodulator. In the current study the effect of this immunomodulator is tested on an experimental asthmatic BALB/c mouse model to investigate its properties on the white blood cell count in the blood and bronchial lavage of the animals since white blood cells play a fundamental role in the inflammatory process involved in asthma. As it is known that platelets also play an important role in the immune system, the ultrastructure of platelets and fibrin networks were also investigated by scanning electron microscopy. The animals were sensitised, nebulized and treated over a period of 43 days until termination. Results from the blood smears as well as the bronchial lavage smears revealed significantly higher eosinophil counts in the asthmatic group compared to the control and treated groups. Changes in the ultrastructure of the platelets and fibrin networks could also be observed, with the Modul8® -treated group appearing similar to that of the control group where thick major and thin minor fibres could clearly be distinguished and a tight mass of platelet aggregate could be observed. Whereas the fibrin networks from the asthmatic animals appeared flimsy with a tight mass of thin fibres covering the thick major fibres. The asthmatic platelet aggregates appeared granular without the tight round appearance of the control platelet aggregates. It is therefore concluded that Modul8® positively influences the white blood cell counts by altering the asthmatic profile to look similar to that of the control. Also, it seems as if Modul8® has a stabilizing effect on the platelets and fibrin networks. From these results it can be suggested that Modul8® might successfully be used in the treatment of inflammatory conditions such as asthma.
author	Oberholzer,Hester Magdalena Vieira,Warren Antonio Pretorius,Etheresia
author_facet	Oberholzer,Hester Magdalena Vieira,Warren Antonio Pretorius,Etheresia
author_sort	Oberholzer,Hester Magdalena
title	Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice
title_short	Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice
title_full	Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice
title_fullStr	Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice
title_full_unstemmed	Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice
title_sort	investigating the effect of the homeopathic immunomodulator, modul8® on blood count, bronchial lavage and fibrin ultrastructure on experimental asthmatic balb/c mice
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300049
work_keys_str_mv	AT oberholzerhestermagdalena investigatingtheeffectofthehomeopathicimmunomodulatormodul8onbloodcountbronchiallavageandfibrinultrastructureonexperimentalasthmaticbalbcmice AT vieirawarrenantonio investigatingtheeffectofthehomeopathicimmunomodulatormodul8onbloodcountbronchiallavageandfibrinultrastructureonexperimentalasthmaticbalbcmice AT pretoriusetheresia investigatingtheeffectofthehomeopathicimmunomodulatormodul8onbloodcountbronchiallavageandfibrinultrastructureonexperimentalasthmaticbalbcmice
_version_	1718444669583491072

Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice

Ejemplares similares