Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model

Propolis, an apitherapic product widely employed in natural medicine, presents various biological properties, such as bactericidal and anti-inflammatory activities, but only few reports have looked at the Brazilian red propolis variety. Collagen films have been employed to improve wound healing and...

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Autores principales:	Albuquerque-Júnior,Ricardo Luiz Cavalcanti de, Barreto,André Luiz Santos, Pires,Jônatas Almeida, Reis,Francisco Prado, Lima,Sônia Oliveira, Ribeiro,Maria Amália Gonzaga, Cardoso,Juliana Cordeiro
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Propolis Wound healing Occlusive dressings Type-I collagen
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400025
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spelling	oai:scielo:S0717-950220090004000252010-05-18Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent ModelAlbuquerque-Júnior,Ricardo Luiz Cavalcanti deBarreto,André Luiz SantosPires,Jônatas AlmeidaReis,Francisco PradoLima,Sônia OliveiraRibeiro,Maria Amália GonzagaCardoso,Juliana Cordeiro Propolis Wound healing Occlusive dressings Type-I collagen Propolis, an apitherapic product widely employed in natural medicine, presents various biological properties, such as bactericidal and anti-inflammatory activities, but only few reports have looked at the Brazilian red propolis variety. Collagen films have been employed to improve wound healing and some studies have investigated the effect of natural products incorporated into these films. Thus, the aim of this study was to analyze the effect of collagen-based films containing red propolis on wound healing. Therefore, wounds performed in the back of rats were dressed with collagen-based films (G2), and collagen-based films containing red propolis (G3); undressed worked as control (G1). After 3, 7 and 14 days the animals were euthanized, and the wounds were microscopically evaluated. In 7 days, G3 showed switch of the inflammatory profile from acute into chronic, increased plasma cells differentiation, replacement of Type-III for type-I collagen fibers, and better architectural organization of those fibers. Furthermore, a slight tendency for a better epithelization was verified in G3, but it was not statistically significant. Also in 7 days, the microvessels count was higher in G1 than in G2 (p=0.000) and G3 (p=0.001), but similar between the last groups (p=0,15), whereas the microvessels perimeter was higher in G1 than in G2 (p=0.000) and G3 (p=0.002), but equivalent in G2 and G3 (p=0.175) in 14 days. In conclusion, the incorporation of Brazilian red propolis into collagen-based films was able to improve wound healing, probably by modulating the dynamics of the inflammatory evolution and collagen deposition process.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400025en10.4067/S0717-95022009000400025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Propolis Wound healing Occlusive dressings Type-I collagen
spellingShingle	Propolis Wound healing Occlusive dressings Type-I collagen Albuquerque-Júnior,Ricardo Luiz Cavalcanti de Barreto,André Luiz Santos Pires,Jônatas Almeida Reis,Francisco Prado Lima,Sônia Oliveira Ribeiro,Maria Amália Gonzaga Cardoso,Juliana Cordeiro Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model
description	Propolis, an apitherapic product widely employed in natural medicine, presents various biological properties, such as bactericidal and anti-inflammatory activities, but only few reports have looked at the Brazilian red propolis variety. Collagen films have been employed to improve wound healing and some studies have investigated the effect of natural products incorporated into these films. Thus, the aim of this study was to analyze the effect of collagen-based films containing red propolis on wound healing. Therefore, wounds performed in the back of rats were dressed with collagen-based films (G2), and collagen-based films containing red propolis (G3); undressed worked as control (G1). After 3, 7 and 14 days the animals were euthanized, and the wounds were microscopically evaluated. In 7 days, G3 showed switch of the inflammatory profile from acute into chronic, increased plasma cells differentiation, replacement of Type-III for type-I collagen fibers, and better architectural organization of those fibers. Furthermore, a slight tendency for a better epithelization was verified in G3, but it was not statistically significant. Also in 7 days, the microvessels count was higher in G1 than in G2 (p=0.000) and G3 (p=0.001), but similar between the last groups (p=0,15), whereas the microvessels perimeter was higher in G1 than in G2 (p=0.000) and G3 (p=0.002), but equivalent in G2 and G3 (p=0.175) in 14 days. In conclusion, the incorporation of Brazilian red propolis into collagen-based films was able to improve wound healing, probably by modulating the dynamics of the inflammatory evolution and collagen deposition process.
author	Albuquerque-Júnior,Ricardo Luiz Cavalcanti de Barreto,André Luiz Santos Pires,Jônatas Almeida Reis,Francisco Prado Lima,Sônia Oliveira Ribeiro,Maria Amália Gonzaga Cardoso,Juliana Cordeiro
author_facet	Albuquerque-Júnior,Ricardo Luiz Cavalcanti de Barreto,André Luiz Santos Pires,Jônatas Almeida Reis,Francisco Prado Lima,Sônia Oliveira Ribeiro,Maria Amália Gonzaga Cardoso,Juliana Cordeiro
author_sort	Albuquerque-Júnior,Ricardo Luiz Cavalcanti de
title	Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model
title_short	Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model
title_full	Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model
title_fullStr	Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model
title_full_unstemmed	Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model
title_sort	effect of bovine type-i collagen-based films containing red propolis on dermal wound healing in rodent model
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400025
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Effect of Bovine Type-I Collagen-Based Films Containing Red Propolis on Dermal Wound Healing in Rodent Model

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