Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats

The aim of this work was to evaluate the effect of albendazole sulphoxide (ABZSO), administered to Wistar rats during pregnancy on embryonic, foetal and placental parameters. A colpocytological control was performed daily and detection of spermatozoa in the vaginal smear was considered as day 0 of p...

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Autores principales:	Teruel,M, García,V, Catalano,R
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Albendazole Sulphoxide Gestation Toxicity Wistar Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400030
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spelling	oai:scielo:S0717-950220090004000302010-05-18Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar RatsTeruel,MGarcía,VCatalano,R Albendazole Sulphoxide Gestation Toxicity Wistar Rats The aim of this work was to evaluate the effect of albendazole sulphoxide (ABZSO), administered to Wistar rats during pregnancy on embryonic, foetal and placental parameters. A colpocytological control was performed daily and detection of spermatozoa in the vaginal smear was considered as day 0 of pregnancy. For the preimplantational study, ABZSO (10 mg/kg) was orally administered at day 2 of pregnancy; at day 4 the embryos were collected. For the postimplantational study, ABZSO (10 mg/kg) was orally administered by gavages at day 2, 6 or 10 of pregnancy (G2, G6 and G10 Groups respectively); the control group was administered the same volume of carboxymethylcellulose vehicle used to prepare the drug suspension. Fetuses were obtained from pregnant rats sacrificed on day 20 of gestation. Maternal body weight gains were analyzed using the one-way ANOVA test. Embryonic and foetal variables were analized on a per litter basis by the Kruskal-Wallis test. Skeletal anomalies were analyzed using an X² test. The significance level accepted was established at P<0.05. In the preimplantational analysis, the cleavage rate was lower in the experimental group (P<0.05). In the postimplantational analysis there were no differences in the net weight increase among females of the different groups (P>0.05). The number of fetuses and the foetal vesicles weight were lower in the G10 group (P<0.05). This group showed the highest percentage of resorptions (P<0.05) and fetuses morphologically abnormal. An increase in the number of bones affected in fetuses of G6 and G10 groups was observed. The most common malformations were at vertebral, costal and head level. Weights and placental diameters were lower in the G10 group (P<0.05). We conclude that ABZSO at the dose used in this study affects the cleavage rate in preimplantational embryo development, without interrupting pregnancy. Furthermore; the developmental toxicity is related to day of administration.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400030en10.4067/S0717-95022009000400030
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Albendazole Sulphoxide Gestation Toxicity Wistar Rats
spellingShingle	Albendazole Sulphoxide Gestation Toxicity Wistar Rats Teruel,M García,V Catalano,R Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats
description	The aim of this work was to evaluate the effect of albendazole sulphoxide (ABZSO), administered to Wistar rats during pregnancy on embryonic, foetal and placental parameters. A colpocytological control was performed daily and detection of spermatozoa in the vaginal smear was considered as day 0 of pregnancy. For the preimplantational study, ABZSO (10 mg/kg) was orally administered at day 2 of pregnancy; at day 4 the embryos were collected. For the postimplantational study, ABZSO (10 mg/kg) was orally administered by gavages at day 2, 6 or 10 of pregnancy (G2, G6 and G10 Groups respectively); the control group was administered the same volume of carboxymethylcellulose vehicle used to prepare the drug suspension. Fetuses were obtained from pregnant rats sacrificed on day 20 of gestation. Maternal body weight gains were analyzed using the one-way ANOVA test. Embryonic and foetal variables were analized on a per litter basis by the Kruskal-Wallis test. Skeletal anomalies were analyzed using an X² test. The significance level accepted was established at P<0.05. In the preimplantational analysis, the cleavage rate was lower in the experimental group (P<0.05). In the postimplantational analysis there were no differences in the net weight increase among females of the different groups (P>0.05). The number of fetuses and the foetal vesicles weight were lower in the G10 group (P<0.05). This group showed the highest percentage of resorptions (P<0.05) and fetuses morphologically abnormal. An increase in the number of bones affected in fetuses of G6 and G10 groups was observed. The most common malformations were at vertebral, costal and head level. Weights and placental diameters were lower in the G10 group (P<0.05). We conclude that ABZSO at the dose used in this study affects the cleavage rate in preimplantational embryo development, without interrupting pregnancy. Furthermore; the developmental toxicity is related to day of administration.
author	Teruel,M García,V Catalano,R
author_facet	Teruel,M García,V Catalano,R
author_sort	Teruel,M
title	Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats
title_short	Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats
title_full	Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats
title_fullStr	Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats
title_full_unstemmed	Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats
title_sort	effects of albendazole sulphoxide on embryonic, foetal and placental parameters in wistar rats
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400030
work_keys_str_mv	AT teruelm effectsofalbendazolesulphoxideonembryonicfoetalandplacentalparametersinwistarrats AT garciav effectsofalbendazolesulphoxideonembryonicfoetalandplacentalparametersinwistarrats AT catalanor effectsofalbendazolesulphoxideonembryonicfoetalandplacentalparametersinwistarrats
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Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats

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