Muscle Response to the Association of Statin and Physical Exercise in Rats

Physical exercise and statins, which are recommended for the treatment of dyslipidemia, are independently associated to the occurrence of muscle injury. The objective is analyze the effect of aerobic exercise associated to the use of simvastatin on the morphology of the gastrocnemius muscle. Thirty...

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Autores principales:	Bonfim,Mariana Rotta, Camargo Filho,José Carlos Silva, Vanderlei,Luiz Carlos Marques, Padulla,Susimary Aparecida Trevizan, Accioly,Marilita Falângola, Souza,Dorotéia Rossi Silva, Azoubel,Reinaldo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Hydroxymethylglutaryl-CoA Reductase Inhibitors Exercise Skeletal Muscle
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400031
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spelling	oai:scielo:S0717-950220090004000312010-05-18Muscle Response to the Association of Statin and Physical Exercise in RatsBonfim,Mariana RottaCamargo Filho,José Carlos SilvaVanderlei,Luiz Carlos MarquesPadulla,Susimary Aparecida TrevizanAccioly,Marilita FalângolaSouza,Dorotéia Rossi SilvaAzoubel,Reinaldo Hydroxymethylglutaryl-CoA Reductase Inhibitors Exercise Skeletal Muscle Physical exercise and statins, which are recommended for the treatment of dyslipidemia, are independently associated to the occurrence of muscle injury. The objective is analyze the effect of aerobic exercise associated to the use of simvastatin on the morphology of the gastrocnemius muscle. Thirty Wistar rats were divided into six groups, two of which received a standard diet (1 sedentary and 1 exercised) and four (1 sedentary with medication, 1 sedentary without medication, 1 exercised with medication, 1 exercised without medication) received a hypercholesterolemic diet (standard diet with the addition of cholesterol and coconut oil). Simvastatin (20 mg/Kg) was administered five days a week for eight weeks, together with aerobic training on a treadmill (9.75 m/min) for 60 minutes a day. The gastrocnemius muscle was removed, sliced, stained with Hematoxylin-Eosin and submitted to a histochemical reaction to determine mitochondrial activity. The data were analyzed using a paired t-test, analysis of variance and Scheffé's post hoc test (p<0.05). Greater histological alterations were found in the medicated and exercised animals, with a greater frequency of occurrence as well. The histochemical analysis revealed that the medicated groups had fibers with more intensive mitochondrial activity alongside fibers with an absence of reaction. The morphometric analysis revealed no significant differences between groups. It is suggested that simvastatin is a medication that leads to the occurrence of muscle injury and its administration in association with physical activity may exacerbate these injuries. This finding may be related to cellular respiration.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400031en10.4067/S0717-95022009000400031
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hydroxymethylglutaryl-CoA Reductase Inhibitors Exercise Skeletal Muscle
spellingShingle	Hydroxymethylglutaryl-CoA Reductase Inhibitors Exercise Skeletal Muscle Bonfim,Mariana Rotta Camargo Filho,José Carlos Silva Vanderlei,Luiz Carlos Marques Padulla,Susimary Aparecida Trevizan Accioly,Marilita Falângola Souza,Dorotéia Rossi Silva Azoubel,Reinaldo Muscle Response to the Association of Statin and Physical Exercise in Rats
description	Physical exercise and statins, which are recommended for the treatment of dyslipidemia, are independently associated to the occurrence of muscle injury. The objective is analyze the effect of aerobic exercise associated to the use of simvastatin on the morphology of the gastrocnemius muscle. Thirty Wistar rats were divided into six groups, two of which received a standard diet (1 sedentary and 1 exercised) and four (1 sedentary with medication, 1 sedentary without medication, 1 exercised with medication, 1 exercised without medication) received a hypercholesterolemic diet (standard diet with the addition of cholesterol and coconut oil). Simvastatin (20 mg/Kg) was administered five days a week for eight weeks, together with aerobic training on a treadmill (9.75 m/min) for 60 minutes a day. The gastrocnemius muscle was removed, sliced, stained with Hematoxylin-Eosin and submitted to a histochemical reaction to determine mitochondrial activity. The data were analyzed using a paired t-test, analysis of variance and Scheffé's post hoc test (p<0.05). Greater histological alterations were found in the medicated and exercised animals, with a greater frequency of occurrence as well. The histochemical analysis revealed that the medicated groups had fibers with more intensive mitochondrial activity alongside fibers with an absence of reaction. The morphometric analysis revealed no significant differences between groups. It is suggested that simvastatin is a medication that leads to the occurrence of muscle injury and its administration in association with physical activity may exacerbate these injuries. This finding may be related to cellular respiration.
author	Bonfim,Mariana Rotta Camargo Filho,José Carlos Silva Vanderlei,Luiz Carlos Marques Padulla,Susimary Aparecida Trevizan Accioly,Marilita Falângola Souza,Dorotéia Rossi Silva Azoubel,Reinaldo
author_facet	Bonfim,Mariana Rotta Camargo Filho,José Carlos Silva Vanderlei,Luiz Carlos Marques Padulla,Susimary Aparecida Trevizan Accioly,Marilita Falângola Souza,Dorotéia Rossi Silva Azoubel,Reinaldo
author_sort	Bonfim,Mariana Rotta
title	Muscle Response to the Association of Statin and Physical Exercise in Rats
title_short	Muscle Response to the Association of Statin and Physical Exercise in Rats
title_full	Muscle Response to the Association of Statin and Physical Exercise in Rats
title_fullStr	Muscle Response to the Association of Statin and Physical Exercise in Rats
title_full_unstemmed	Muscle Response to the Association of Statin and Physical Exercise in Rats
title_sort	muscle response to the association of statin and physical exercise in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400031
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Muscle Response to the Association of Statin and Physical Exercise in Rats

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