Sex Variation in Occurrence of Myocardium in Human Mitral Valve Cusps

Mitral valve cusps consist mainly of connective tissue and myocardium. Connective tissue fibres within the cusps have been demonstrated to exhibit sex variations in organisation. Mitral prolapse, a disease attributed to defects within the cusps occurs more commonly in females. Sex variations in valv...

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Autores principales:	Gatonga,P, Odula,P. O, Saidi,H, Mandela,P
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Mitral valve Cusp Structure Variation Sex
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400041
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spelling	oai:scielo:S0717-950220090004000412010-05-18Sex Variation in Occurrence of Myocardium in Human Mitral Valve CuspsGatonga,POdula,P. OSaidi,HMandela,P Mitral valve Cusp Structure Variation Sex Mitral valve cusps consist mainly of connective tissue and myocardium. Connective tissue fibres within the cusps have been demonstrated to exhibit sex variations in organisation. Mitral prolapse, a disease attributed to defects within the cusps occurs more commonly in females. Sex variations in valvular myocardium however remain to be studied. Possible variations in its organisation may enhance understanding of sex differences in prevalence of mitral prolapse. The aim of this study was to determine anatomical variations of mitral valvular myocardium by sex; by mean a comparative cross-sectional study. A total of 48 (27 male and 21 female) adult heart specimens obtained during autopsy at Nairobi City and Chiromo mortuaries after ethical approval were used. Valvular cusps were then harvested. Four millimetre sections were made at the area of maximum width for both anterior and posterior cusps. These were processed for paraffin-embedding and sectioning and stained with Masson's trichrome and Weigert's resorcin fuchsin with Van Gieson counterstain to demonstrate cardiac muscle, collagen and elastic fibres. Both anterior and posterior cusps demonstrated three histological laminae, that is, atrialis, fibrosa and ventricularis. Only lamina atrialis contained cardiac muscle. This lamina in males was characterised by a transversely oriented subendothelial myocardial strip while that in females contained compact longitudinal elastic fibres but no muscle. The presence of cardiac muscle in the lamina atrialis may be relatively protective against mitral valve prolapse in males compared to females.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400041en10.4067/S0717-95022009000400041
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mitral valve Cusp Structure Variation Sex
spellingShingle	Mitral valve Cusp Structure Variation Sex Gatonga,P Odula,P. O Saidi,H Mandela,P Sex Variation in Occurrence of Myocardium in Human Mitral Valve Cusps
description	Mitral valve cusps consist mainly of connective tissue and myocardium. Connective tissue fibres within the cusps have been demonstrated to exhibit sex variations in organisation. Mitral prolapse, a disease attributed to defects within the cusps occurs more commonly in females. Sex variations in valvular myocardium however remain to be studied. Possible variations in its organisation may enhance understanding of sex differences in prevalence of mitral prolapse. The aim of this study was to determine anatomical variations of mitral valvular myocardium by sex; by mean a comparative cross-sectional study. A total of 48 (27 male and 21 female) adult heart specimens obtained during autopsy at Nairobi City and Chiromo mortuaries after ethical approval were used. Valvular cusps were then harvested. Four millimetre sections were made at the area of maximum width for both anterior and posterior cusps. These were processed for paraffin-embedding and sectioning and stained with Masson's trichrome and Weigert's resorcin fuchsin with Van Gieson counterstain to demonstrate cardiac muscle, collagen and elastic fibres. Both anterior and posterior cusps demonstrated three histological laminae, that is, atrialis, fibrosa and ventricularis. Only lamina atrialis contained cardiac muscle. This lamina in males was characterised by a transversely oriented subendothelial myocardial strip while that in females contained compact longitudinal elastic fibres but no muscle. The presence of cardiac muscle in the lamina atrialis may be relatively protective against mitral valve prolapse in males compared to females.
author	Gatonga,P Odula,P. O Saidi,H Mandela,P
author_facet	Gatonga,P Odula,P. O Saidi,H Mandela,P
author_sort	Gatonga,P
title	Sex Variation in Occurrence of Myocardium in Human Mitral Valve Cusps
title_short	Sex Variation in Occurrence of Myocardium in Human Mitral Valve Cusps
title_full	Sex Variation in Occurrence of Myocardium in Human Mitral Valve Cusps
title_fullStr	Sex Variation in Occurrence of Myocardium in Human Mitral Valve Cusps
title_full_unstemmed	Sex Variation in Occurrence of Myocardium in Human Mitral Valve Cusps
title_sort	sex variation in occurrence of myocardium in human mitral valve cusps
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400041
work_keys_str_mv	AT gatongap sexvariationinoccurrenceofmyocardiuminhumanmitralvalvecusps AT odulapo sexvariationinoccurrenceofmyocardiuminhumanmitralvalvecusps AT saidih sexvariationinoccurrenceofmyocardiuminhumanmitralvalvecusps AT mandelap sexvariationinoccurrenceofmyocardiuminhumanmitralvalvecusps
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Sex Variation in Occurrence of Myocardium in Human Mitral Valve Cusps

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