Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats

Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the l...

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Autores principales:	Golalipour,Mohammad Jafar, Ghafari,Soraya, Farsi,Mir Mehrdad
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Diabetes Urtica dioica Liver Hepatocyte Morphometry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400058
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spelling	oai:scielo:S0717-950220090004000582010-05-18Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic RatsGolalipour,Mohammad JafarGhafari,SorayaFarsi,Mir Mehrdad Diabetes Urtica dioica Liver Hepatocyte Morphometry Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the livers in STZ diabetic rats. Thirty male Wistar rats were allocated in 3 groups: normal, diabetic and treatment. Hyperglycemia was induced by 80 mg/kg Streptozotocin intraperitoneally. One week after the injection of STZ, the third group received the hydroalcoholic extract of Urtica dioica at 100 mg/kg/day over four weeks. After five weeks, the animals were sacrificed and whole livers were removed. Liver specimens were used for quantitative morphometric analyze after hematoxylin and eosin staining. All data are shown as means plus standard errors of means and were analyzed using One-Way ANOVA test at P<0.05.The mean area of hepatocytes, nuclei and nucleolus had a decrease in periportal zone and an increase in perivenous zone in the diabetic and treatment groups. The increase of hepatocyte area in perivenous zone and reduce of nucleus area in periportal zone was significant in the diabetic group in comparison with control group (P<0.05), but were not significant between treatment and diabetic group. This study showed that administration of 100 mg/kg/day of Urtica dioica leaves extracts after induction of diabetes can cause a little modulating in the main morphometric indices of liver such as area of hepatocytes, nuclei and nucleolus in periportal and perivenous zones.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400058en10.4067/S0717-95022009000400058
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes Urtica dioica Liver Hepatocyte Morphometry
spellingShingle	Diabetes Urtica dioica Liver Hepatocyte Morphometry Golalipour,Mohammad Jafar Ghafari,Soraya Farsi,Mir Mehrdad Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats
description	Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the livers in STZ diabetic rats. Thirty male Wistar rats were allocated in 3 groups: normal, diabetic and treatment. Hyperglycemia was induced by 80 mg/kg Streptozotocin intraperitoneally. One week after the injection of STZ, the third group received the hydroalcoholic extract of Urtica dioica at 100 mg/kg/day over four weeks. After five weeks, the animals were sacrificed and whole livers were removed. Liver specimens were used for quantitative morphometric analyze after hematoxylin and eosin staining. All data are shown as means plus standard errors of means and were analyzed using One-Way ANOVA test at P<0.05.The mean area of hepatocytes, nuclei and nucleolus had a decrease in periportal zone and an increase in perivenous zone in the diabetic and treatment groups. The increase of hepatocyte area in perivenous zone and reduce of nucleus area in periportal zone was significant in the diabetic group in comparison with control group (P<0.05), but were not significant between treatment and diabetic group. This study showed that administration of 100 mg/kg/day of Urtica dioica leaves extracts after induction of diabetes can cause a little modulating in the main morphometric indices of liver such as area of hepatocytes, nuclei and nucleolus in periportal and perivenous zones.
author	Golalipour,Mohammad Jafar Ghafari,Soraya Farsi,Mir Mehrdad
author_facet	Golalipour,Mohammad Jafar Ghafari,Soraya Farsi,Mir Mehrdad
author_sort	Golalipour,Mohammad Jafar
title	Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats
title_short	Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats
title_full	Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats
title_fullStr	Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats
title_full_unstemmed	Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats
title_sort	effect of urtica dioica l extract on quantitative morphometric alterations of liver parenchymal cells in stz diabetic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400058
work_keys_str_mv	AT golalipourmohammadjafar effectofurticadioicalextractonquantitativemorphometricalterationsofliverparenchymalcellsinstzdiabeticrats AT ghafarisoraya effectofurticadioicalextractonquantitativemorphometricalterationsofliverparenchymalcellsinstzdiabeticrats AT farsimirmehrdad effectofurticadioicalextractonquantitativemorphometricalterationsofliverparenchymalcellsinstzdiabeticrats
_version_	1718444680112242688

Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats

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