The Dual Role of Senescence in Tumorigenesis

Senescence was rendered a tumor suppressor mechanism based on the observation of its protective effect against cancer in young organisms under conditions of oncogene activation or inactivation of tumor suppressor genes. In addition to this beneficial effect, senescence has been deemed to have age-as...

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Autores principales:	Chuaire-Noack,Lilian, Sánchez-Corredor,Magda Carolina, Ramírez-Clavijo,Sandra Rocío
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Senescence Cancer Antagonistic pleiotropism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100006
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spelling	oai:scielo:S0717-950220100001000062010-07-05The Dual Role of Senescence in TumorigenesisChuaire-Noack,LilianSánchez-Corredor,Magda CarolinaRamírez-Clavijo,Sandra Rocío Senescence Cancer Antagonistic pleiotropism Senescence was rendered a tumor suppressor mechanism based on the observation of its protective effect against cancer in young organisms under conditions of oncogene activation or inactivation of tumor suppressor genes. In addition to this beneficial effect, senescence has been deemed to have age-associated deleterious effects because, apparently, senescence not only recapitulates aging and therefore loss of function and tissue regeneration capacity, but can also induce preneoplastic changes in adjacent stromal cells, provoke degenerative diseases or induce the production of tumor cell growth promoting factors. For that reason, senescence has become an attractive therapeutic target against cancer. This paper reviews some of the latest findings on the role of senescence in the malignant progression and analyzes them in relation to the concept of antagonistic pleiotropism, as well as its possible use as a therapeutic target against cancer.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.1 20102010-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100006en10.4067/S0717-95022010000100006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Senescence Cancer Antagonistic pleiotropism
spellingShingle	Senescence Cancer Antagonistic pleiotropism Chuaire-Noack,Lilian Sánchez-Corredor,Magda Carolina Ramírez-Clavijo,Sandra Rocío The Dual Role of Senescence in Tumorigenesis
description	Senescence was rendered a tumor suppressor mechanism based on the observation of its protective effect against cancer in young organisms under conditions of oncogene activation or inactivation of tumor suppressor genes. In addition to this beneficial effect, senescence has been deemed to have age-associated deleterious effects because, apparently, senescence not only recapitulates aging and therefore loss of function and tissue regeneration capacity, but can also induce preneoplastic changes in adjacent stromal cells, provoke degenerative diseases or induce the production of tumor cell growth promoting factors. For that reason, senescence has become an attractive therapeutic target against cancer. This paper reviews some of the latest findings on the role of senescence in the malignant progression and analyzes them in relation to the concept of antagonistic pleiotropism, as well as its possible use as a therapeutic target against cancer.
author	Chuaire-Noack,Lilian Sánchez-Corredor,Magda Carolina Ramírez-Clavijo,Sandra Rocío
author_facet	Chuaire-Noack,Lilian Sánchez-Corredor,Magda Carolina Ramírez-Clavijo,Sandra Rocío
author_sort	Chuaire-Noack,Lilian
title	The Dual Role of Senescence in Tumorigenesis
title_short	The Dual Role of Senescence in Tumorigenesis
title_full	The Dual Role of Senescence in Tumorigenesis
title_fullStr	The Dual Role of Senescence in Tumorigenesis
title_full_unstemmed	The Dual Role of Senescence in Tumorigenesis
title_sort	dual role of senescence in tumorigenesis
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100006
work_keys_str_mv	AT chuairenoacklilian thedualroleofsenescenceintumorigenesis AT sanchezcorredormagdacarolina thedualroleofsenescenceintumorigenesis AT ramirezclavijosandrarocio thedualroleofsenescenceintumorigenesis AT chuairenoacklilian dualroleofsenescenceintumorigenesis AT sanchezcorredormagdacarolina dualroleofsenescenceintumorigenesis AT ramirezclavijosandrarocio dualroleofsenescenceintumorigenesis
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The Dual Role of Senescence in Tumorigenesis

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