Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of Sepsis

Approximately, half of the patients with progressive sepsis develop encephalopathy, but there is scarce knowledge onto question that how the sepsis associated encephalopathy contributes brain dysfunction. Hippocampus is one of the most vulnerable regions during experimental sepsis. In the present st...

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Autores principales:	Kafa,Ilker M, Ari,Ilknur, Kurt,M. Ayberk
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Sepsis Animal models of sepsis Faecal peritonitis Hippocampus Sepsis associated encephalopathy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100026
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spelling	oai:scielo:S0717-950220100001000262010-07-05Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of SepsisKafa,Ilker MAri,IlknurKurt,M. Ayberk Sepsis Animal models of sepsis Faecal peritonitis Hippocampus Sepsis associated encephalopathy Approximately, half of the patients with progressive sepsis develop encephalopathy, but there is scarce knowledge onto question that how the sepsis associated encephalopathy contributes brain dysfunction. Hippocampus is one of the most vulnerable regions during experimental sepsis. In the present study, effects of sepsis on the neuronal density and morphology in CA1, CA3 and DG areas were investigated in a rat model of intraperitoneal sepsis. Twenty-four Wistar rats were divided into three different groups: faecal peritonitis group, sham-operated and un-operated control groups. Pyramidal neuron volume density was significantly higher in CA1 area of the faecal peritonitis group compared to both un-operated (p<0.05) and sham-operated (p<0.05) groups. Pyramidal neuron volume density was also significantly higher in CA3 area of the faecal peritonitis group compared to both un-operated (p<0.05) and sham-operated (p<0.05) groups. Mean nuclear diameter of pyramidal neurons in CA1 area of the faecal peritonitis group was significantly lower (p<0.05) compared to un-operated control group. Dark, shrunken neurons were frequently observed and neuroglial cells appeared to be prevalent in the faecal peritonitis group compared to control groups. These results collectively suggest that intraperitoneal sepsis does not initiate cell death in the early stages of sepsis, although morphological signs of neurodegeneration start to appear.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.1 20102010-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100026en10.4067/S0717-95022010000100026
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sepsis Animal models of sepsis Faecal peritonitis Hippocampus Sepsis associated encephalopathy
spellingShingle	Sepsis Animal models of sepsis Faecal peritonitis Hippocampus Sepsis associated encephalopathy Kafa,Ilker M Ari,Ilknur Kurt,M. Ayberk Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of Sepsis
description	Approximately, half of the patients with progressive sepsis develop encephalopathy, but there is scarce knowledge onto question that how the sepsis associated encephalopathy contributes brain dysfunction. Hippocampus is one of the most vulnerable regions during experimental sepsis. In the present study, effects of sepsis on the neuronal density and morphology in CA1, CA3 and DG areas were investigated in a rat model of intraperitoneal sepsis. Twenty-four Wistar rats were divided into three different groups: faecal peritonitis group, sham-operated and un-operated control groups. Pyramidal neuron volume density was significantly higher in CA1 area of the faecal peritonitis group compared to both un-operated (p<0.05) and sham-operated (p<0.05) groups. Pyramidal neuron volume density was also significantly higher in CA3 area of the faecal peritonitis group compared to both un-operated (p<0.05) and sham-operated (p<0.05) groups. Mean nuclear diameter of pyramidal neurons in CA1 area of the faecal peritonitis group was significantly lower (p<0.05) compared to un-operated control group. Dark, shrunken neurons were frequently observed and neuroglial cells appeared to be prevalent in the faecal peritonitis group compared to control groups. These results collectively suggest that intraperitoneal sepsis does not initiate cell death in the early stages of sepsis, although morphological signs of neurodegeneration start to appear.
author	Kafa,Ilker M Ari,Ilknur Kurt,M. Ayberk
author_facet	Kafa,Ilker M Ari,Ilknur Kurt,M. Ayberk
author_sort	Kafa,Ilker M
title	Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of Sepsis
title_short	Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of Sepsis
title_full	Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of Sepsis
title_fullStr	Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of Sepsis
title_full_unstemmed	Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of Sepsis
title_sort	morphometric investigation of neurons in the hippocampal ca1, ca3 areas and dentate gyrus in a rat model of sepsis
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100026
work_keys_str_mv	AT kafailkerm morphometricinvestigationofneuronsinthehippocampalca1ca3areasanddentategyrusinaratmodelofsepsis AT ariilknur morphometricinvestigationofneuronsinthehippocampalca1ca3areasanddentategyrusinaratmodelofsepsis AT kurtmayberk morphometricinvestigationofneuronsinthehippocampalca1ca3areasanddentategyrusinaratmodelofsepsis
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Morphometric Investigation of Neurons in the Hippocampal CA1, CA3 Areas and Dentate Gyrus in a Rat Model of Sepsis

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