Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin

There are some medications and procedures that can be used to accelerate the healing of skin wounds. Some studies have demonstrated improvement of burn wound healing with honey treatment. In other hand, based on traditional medicine have improved wound healing with animal oil. This study was done to...

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Autores principales:	Ghaderi,Reza, Afshar,Mohammad, Akhbarie,Hadi, Golalipour,Mohammad Jafar
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Honey Animal oil Wound healing Skin Mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100027
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spelling	oai:scielo:S0717-950220100001000272010-07-05Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skinGhaderi,RezaAfshar,MohammadAkhbarie,HadiGolalipour,Mohammad Jafar Honey Animal oil Wound healing Skin Mice There are some medications and procedures that can be used to accelerate the healing of skin wounds. Some studies have demonstrated improvement of burn wound healing with honey treatment. In other hand, based on traditional medicine have improved wound healing with animal oil. This study was done to compare the efficacy of animal oil and honey in accelerating healing of full thickness wound of skin in mice. In this experimental study 36 male NMRI mice were subjected to full-thickness skin wounds under general anesthesia. Animals were randomly allocated to receive either single daily applications of placebo, animal oil and honey (n=12 for each group) respectively. On 4th, 7th and 10th days, four mice from each group were sacrificed using an overdose of anesthetic. Macroscopic and Microscopic characteristic of wounds were studied pathologically and histologically. The findings of this study showed that formation of granulation tissue, density and activation of fibroblasts, keratinization in surface of wound and thickness of basement membrane and epidermis in Honey treatment group was more than animal oil group. Honey more than animal oil decreased inflammation, edema and dehiscence of wound in mice. The wound healing rate in honey group was higher than in animal oil group (p<0.05). This study showed that honey more than animal oil accelerates healing of full thickness wound of skin in mice.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.1 20102010-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100027en10.4067/S0717-95022010000100027
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Honey Animal oil Wound healing Skin Mice
spellingShingle	Honey Animal oil Wound healing Skin Mice Ghaderi,Reza Afshar,Mohammad Akhbarie,Hadi Golalipour,Mohammad Jafar Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin
description	There are some medications and procedures that can be used to accelerate the healing of skin wounds. Some studies have demonstrated improvement of burn wound healing with honey treatment. In other hand, based on traditional medicine have improved wound healing with animal oil. This study was done to compare the efficacy of animal oil and honey in accelerating healing of full thickness wound of skin in mice. In this experimental study 36 male NMRI mice were subjected to full-thickness skin wounds under general anesthesia. Animals were randomly allocated to receive either single daily applications of placebo, animal oil and honey (n=12 for each group) respectively. On 4th, 7th and 10th days, four mice from each group were sacrificed using an overdose of anesthetic. Macroscopic and Microscopic characteristic of wounds were studied pathologically and histologically. The findings of this study showed that formation of granulation tissue, density and activation of fibroblasts, keratinization in surface of wound and thickness of basement membrane and epidermis in Honey treatment group was more than animal oil group. Honey more than animal oil decreased inflammation, edema and dehiscence of wound in mice. The wound healing rate in honey group was higher than in animal oil group (p<0.05). This study showed that honey more than animal oil accelerates healing of full thickness wound of skin in mice.
author	Ghaderi,Reza Afshar,Mohammad Akhbarie,Hadi Golalipour,Mohammad Jafar
author_facet	Ghaderi,Reza Afshar,Mohammad Akhbarie,Hadi Golalipour,Mohammad Jafar
author_sort	Ghaderi,Reza
title	Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin
title_short	Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin
title_full	Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin
title_fullStr	Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin
title_full_unstemmed	Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin
title_sort	comparison of the efficacy of honey and animal oil in accelerating healing of full thickness wound of mice skin
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100027
work_keys_str_mv	AT ghaderireza comparisonoftheefficacyofhoneyandanimaloilinacceleratinghealingoffullthicknesswoundofmiceskin AT afsharmohammad comparisonoftheefficacyofhoneyandanimaloilinacceleratinghealingoffullthicknesswoundofmiceskin AT akhbariehadi comparisonoftheefficacyofhoneyandanimaloilinacceleratinghealingoffullthicknesswoundofmiceskin AT golalipourmohammadjafar comparisonoftheefficacyofhoneyandanimaloilinacceleratinghealingoffullthicknesswoundofmiceskin
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Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin

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