Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes

Botanical drugs are complementary therapies in the management of diabetes mellitus. In this work, we studied the effects of chronic treatment of diabetic rats with A. indica (neem) on blood glucose, pancreatic islet histopathology, and oxidative status of the pancreas. Fifty-four Wistar rats (5-8 we...

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Autores principales:	Akinola,Oluwole B, Caxton-Martins,Ezekiel A, Dini,Luciana
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Azadirachta indica Pancreatic islet lesion Diabetes mellitus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100043
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spelling	oai:scielo:S0717-950220100001000432010-07-05Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin DiabetesAkinola,Oluwole BCaxton-Martins,Ezekiel ADini,Luciana Azadirachta indica Pancreatic islet lesion Diabetes mellitus Botanical drugs are complementary therapies in the management of diabetes mellitus. In this work, we studied the effects of chronic treatment of diabetic rats with A. indica (neem) on blood glucose, pancreatic islet histopathology, and oxidative status of the pancreas. Fifty-four Wistar rats (5-8 weeks old) were randomly assigned to 5 treatment groups. Hyperglycemia was induced in 34 fasted rats with a single i.p. injection of STZ (70 mg/kg bw/d). Ethanolic extract of A. indica leaves (500 mg/kg bw/d) was given orally to diabetic rats (n=12) for 50d. Glibenclamide was given (p.o) at 600 µg/ kg bw/d. In each group, blood glucose, islet histopathology, and pancreatic oxidative status, were assessed. All hyperglycemic rats in the neem-treated group had become normoglycemic at the end of week 2. By 50d, the number of viable b cells was highest in the neem-treated diabetic rats (compared with the diabetic and glibenclamide groups). Similarly, islet histology showed marked improvement in this group, in addition to improved oxidative stress. Our findings confirmed the hypoglycemic effect of neem. Besides, the improved islet morphology and oxidative status in neem-treated diabetic rats suggest the potential of this herb at improving lesions of the pancreatic islet in diabetes mellitus.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.1 20102010-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100043en10.4067/S0717-95022010000100043
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Azadirachta indica Pancreatic islet lesion Diabetes mellitus
spellingShingle	Azadirachta indica Pancreatic islet lesion Diabetes mellitus Akinola,Oluwole B Caxton-Martins,Ezekiel A Dini,Luciana Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes
description	Botanical drugs are complementary therapies in the management of diabetes mellitus. In this work, we studied the effects of chronic treatment of diabetic rats with A. indica (neem) on blood glucose, pancreatic islet histopathology, and oxidative status of the pancreas. Fifty-four Wistar rats (5-8 weeks old) were randomly assigned to 5 treatment groups. Hyperglycemia was induced in 34 fasted rats with a single i.p. injection of STZ (70 mg/kg bw/d). Ethanolic extract of A. indica leaves (500 mg/kg bw/d) was given orally to diabetic rats (n=12) for 50d. Glibenclamide was given (p.o) at 600 µg/ kg bw/d. In each group, blood glucose, islet histopathology, and pancreatic oxidative status, were assessed. All hyperglycemic rats in the neem-treated group had become normoglycemic at the end of week 2. By 50d, the number of viable b cells was highest in the neem-treated diabetic rats (compared with the diabetic and glibenclamide groups). Similarly, islet histology showed marked improvement in this group, in addition to improved oxidative stress. Our findings confirmed the hypoglycemic effect of neem. Besides, the improved islet morphology and oxidative status in neem-treated diabetic rats suggest the potential of this herb at improving lesions of the pancreatic islet in diabetes mellitus.
author	Akinola,Oluwole B Caxton-Martins,Ezekiel A Dini,Luciana
author_facet	Akinola,Oluwole B Caxton-Martins,Ezekiel A Dini,Luciana
author_sort	Akinola,Oluwole B
title	Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes
title_short	Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes
title_full	Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes
title_fullStr	Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes
title_full_unstemmed	Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes
title_sort	chronic treatment with ethanolic extract of the leavesof azadirachta indica ameliorates lesions of pancreatic islets in streptozotocin diabetes
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100043
work_keys_str_mv	AT akinolaoluwoleb chronictreatmentwithethanolicextractoftheleavesofazadirachtaindicaameliorateslesionsofpancreaticisletsinstreptozotocindiabetes AT caxtonmartinsezekiela chronictreatmentwithethanolicextractoftheleavesofazadirachtaindicaameliorateslesionsofpancreaticisletsinstreptozotocindiabetes AT diniluciana chronictreatmentwithethanolicextractoftheleavesofazadirachtaindicaameliorateslesionsofpancreaticisletsinstreptozotocindiabetes
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Chronic Treatment with Ethanolic Extract of the Leavesof Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes

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