Interlinkages in the Tunica Media of Goat Aorta

The arrangement and interconnections between various components of the aortic wall influence its physicomechanical properties and functional alterations that occur in disease and ageing. The goat is a suitable model for studying cardiovascular disease, but details of the intrinsic organization of it...

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Autores principales:	Ogeng'o,Julius, Malek,Adel Abdel, Kiama,Stephen
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Matrix Smooth muscle Interlinkage Aorta Goat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200013
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spelling	oai:scielo:S0717-950220100002000132010-10-21Interlinkages in the Tunica Media of Goat AortaOgeng'o,JuliusMalek,Adel AbdelKiama,Stephen Matrix Smooth muscle Interlinkage Aorta Goat The arrangement and interconnections between various components of the aortic wall influence its physicomechanical properties and functional alterations that occur in disease and ageing. The goat is a suitable model for studying cardiovascular disease, but details of the intrinsic organization of its aorta are unknown. This study therefore investigated the histomorphology of aortic tunica media in the goat by transmission electron microscopy. Sixteen healthy juvenile and adult domestic male goats (capra hircus) purchased from livestock farms in the outskirts of Nairobi were used in the study. The animals were euthanized with overdose of sodium pentabarbitone 20mg/kg, and fixed with 3% phosphate buffered glutaraldehyde solution by gravimetric perfusion. Specimens obtained from the thoracic aorta (T9) were post fixed in osmium tetroxide, and prepared for durcupan embedding. Ultrathin sections stained with uranyl acetate/lead citrate were examined by EM 201 Phillips © electron microscope. Elastic and collagen fibres were structurally interconnected. Elastic lamellae, collagen and elastic fibres were linked to smooth muscle cells through areas of high electron density while smooth muscle cells were interconnected various inter cellular connections. The physical interlinkages between the components of the tunica media confer plasticity, adaptability and flexibility to the aortic wall enabling it to function as a mechanically homogenous structure. Disruptions of this structure in atherosclerosis and aging may disturb the vascular integrity and predispose to aneurysm formation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200013en10.4067/S0717-95022010000200013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Matrix Smooth muscle Interlinkage Aorta Goat
spellingShingle	Matrix Smooth muscle Interlinkage Aorta Goat Ogeng'o,Julius Malek,Adel Abdel Kiama,Stephen Interlinkages in the Tunica Media of Goat Aorta
description	The arrangement and interconnections between various components of the aortic wall influence its physicomechanical properties and functional alterations that occur in disease and ageing. The goat is a suitable model for studying cardiovascular disease, but details of the intrinsic organization of its aorta are unknown. This study therefore investigated the histomorphology of aortic tunica media in the goat by transmission electron microscopy. Sixteen healthy juvenile and adult domestic male goats (capra hircus) purchased from livestock farms in the outskirts of Nairobi were used in the study. The animals were euthanized with overdose of sodium pentabarbitone 20mg/kg, and fixed with 3% phosphate buffered glutaraldehyde solution by gravimetric perfusion. Specimens obtained from the thoracic aorta (T9) were post fixed in osmium tetroxide, and prepared for durcupan embedding. Ultrathin sections stained with uranyl acetate/lead citrate were examined by EM 201 Phillips © electron microscope. Elastic and collagen fibres were structurally interconnected. Elastic lamellae, collagen and elastic fibres were linked to smooth muscle cells through areas of high electron density while smooth muscle cells were interconnected various inter cellular connections. The physical interlinkages between the components of the tunica media confer plasticity, adaptability and flexibility to the aortic wall enabling it to function as a mechanically homogenous structure. Disruptions of this structure in atherosclerosis and aging may disturb the vascular integrity and predispose to aneurysm formation.
author	Ogeng'o,Julius Malek,Adel Abdel Kiama,Stephen
author_facet	Ogeng'o,Julius Malek,Adel Abdel Kiama,Stephen
author_sort	Ogeng'o,Julius
title	Interlinkages in the Tunica Media of Goat Aorta
title_short	Interlinkages in the Tunica Media of Goat Aorta
title_full	Interlinkages in the Tunica Media of Goat Aorta
title_fullStr	Interlinkages in the Tunica Media of Goat Aorta
title_full_unstemmed	Interlinkages in the Tunica Media of Goat Aorta
title_sort	interlinkages in the tunica media of goat aorta
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200013
work_keys_str_mv	AT ogengojulius interlinkagesinthetunicamediaofgoataorta AT malekadelabdel interlinkagesinthetunicamediaofgoataorta AT kiamastephen interlinkagesinthetunicamediaofgoataorta
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Interlinkages in the Tunica Media of Goat Aorta

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