Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity
Treatment of supraventricular arrhythmia includes a wide range of medical interventions. Herbal remedies are suitable alternatives to synthetic drugs due to their availability, minimal side effects and lower price. Pharmacological studies and traditional medical literature point to the cardiovascula...
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Sociedad Chilena de Anatomía
2010
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oai:scielo:S0717-950220100002000192010-10-21Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain ToxicityKhori,VahidNayebpour,MohsenMansourian,Azad RezaDavarian,AliNaseri,MohsenSalehi,ArefAlizadeh,Ali-Mohamad Citrus aurantium Isolated AV-node Arrhythmia Herbal drugs Treatment of supraventricular arrhythmia includes a wide range of medical interventions. Herbal remedies are suitable alternatives to synthetic drugs due to their availability, minimal side effects and lower price. Pharmacological studies and traditional medical literature point to the cardiovascular effects of Citrus aurantium L. (Rutaceae) in many instances. In the present study we used isolated perfused AV-node of rabbit as an experimental model to determine the effect of various concentrations of essential oil of C. aurantium (0.1-0.3 v/v) on the nodal conduction time and refractoriness of an isolated rabbit AV-nodal preparations. Selective stimulation protocols were used to independently quantify AV nodal recovery, facilitation and fatigue in 18 rabbits. Our results showed concentration-dependent and rate-independent suppressive effects of essence of C. aurantium on the Wenchebach cycle length (WBCL), AV Conduction Time (AVCT) and effective and functional refractory periods (ERP & FRP). Functional properties such as facilitation and fatigue were significantly increased by this plant. Citrus aurantium plays a protective role against the toxic effects of ouabaine by increasing AV nodal conduction time and refractoriness. The above results indicated differential effects of C. aurantium on slow and fast pathways, with a dominant role on fast pathways. This research has explained the protective role of C. aurantium on ouabaine toxicity. All results indicated the potential anti-arrhythmic effects of C. aurantium in treating supraventricular tachyarrhythmia.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200019en10.4067/S0717-95022010000200019 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Citrus aurantium Isolated AV-node Arrhythmia Herbal drugs |
| spellingShingle |
Citrus aurantium Isolated AV-node Arrhythmia Herbal drugs Khori,Vahid Nayebpour,Mohsen Mansourian,Azad Reza Davarian,Ali Naseri,Mohsen Salehi,Aref Alizadeh,Ali-Mohamad Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity |
| description |
Treatment of supraventricular arrhythmia includes a wide range of medical interventions. Herbal remedies are suitable alternatives to synthetic drugs due to their availability, minimal side effects and lower price. Pharmacological studies and traditional medical literature point to the cardiovascular effects of Citrus aurantium L. (Rutaceae) in many instances. In the present study we used isolated perfused AV-node of rabbit as an experimental model to determine the effect of various concentrations of essential oil of C. aurantium (0.1-0.3 v/v) on the nodal conduction time and refractoriness of an isolated rabbit AV-nodal preparations. Selective stimulation protocols were used to independently quantify AV nodal recovery, facilitation and fatigue in 18 rabbits. Our results showed concentration-dependent and rate-independent suppressive effects of essence of C. aurantium on the Wenchebach cycle length (WBCL), AV Conduction Time (AVCT) and effective and functional refractory periods (ERP & FRP). Functional properties such as facilitation and fatigue were significantly increased by this plant. Citrus aurantium plays a protective role against the toxic effects of ouabaine by increasing AV nodal conduction time and refractoriness. The above results indicated differential effects of C. aurantium on slow and fast pathways, with a dominant role on fast pathways. This research has explained the protective role of C. aurantium on ouabaine toxicity. All results indicated the potential anti-arrhythmic effects of C. aurantium in treating supraventricular tachyarrhythmia. |
| author |
Khori,Vahid Nayebpour,Mohsen Mansourian,Azad Reza Davarian,Ali Naseri,Mohsen Salehi,Aref Alizadeh,Ali-Mohamad |
| author_facet |
Khori,Vahid Nayebpour,Mohsen Mansourian,Azad Reza Davarian,Ali Naseri,Mohsen Salehi,Aref Alizadeh,Ali-Mohamad |
| author_sort |
Khori,Vahid |
| title |
Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity |
| title_short |
Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity |
| title_full |
Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity |
| title_fullStr |
Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity |
| title_full_unstemmed |
Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity |
| title_sort |
altered levels of nodal excitability by rate-dependent inhibitory effects of essential oil of citrus aurantium on the electrophysiological properties of isolated perfused rabbit av-node: protective role in the prevention of ouabain toxicity |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2010 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200019 |
| work_keys_str_mv |
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| _version_ |
1718444692856635392 |