Modified Model of Sub-Critical Size Cranial Defect in the Rabbit

In medical sciences, any experimental animal model should be reproducible and adequate to the purpose of simulated human physiological response. In bone injury response research, when bone substitutes are in use, it is of primary importance that studied defects fail to heal unless treated with the t...

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Autores principales:	Marques,J. M, Viegas,C, Dias,M. I, Zagalo,C, Gomes,P, Fernandes,M. H, Santos,J. D, Cabrita,S. C
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Rabbit Cranial vault Trephine defect
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200031
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spelling	oai:scielo:S0717-950220100002000312010-10-21Modified Model of Sub-Critical Size Cranial Defect in the RabbitMarques,J. MViegas,CDias,M. IZagalo,CGomes,PFernandes,M. HSantos,J. DCabrita,S. C Rabbit Cranial vault Trephine defect In medical sciences, any experimental animal model should be reproducible and adequate to the purpose of simulated human physiological response. In bone injury response research, when bone substitutes are in use, it is of primary importance that studied defects fail to heal unless treated with the tissue engineering therapy under study. This failure defines the concept of "critical size defect" (CSD) wich has different limits according to the animal species used and the location of the defect. Although this is a basic concept, when the aim of the study is to investigate the interface Bone-Biomaterial, it is of primary importance to obtain as much contact area as possible. In order to do so, we propose a modified surgical approach to the classical bi-parietal round sub-critical defect model in rabbit vault.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200031en10.4067/S0717-95022010000200031
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Rabbit Cranial vault Trephine defect
spellingShingle	Rabbit Cranial vault Trephine defect Marques,J. M Viegas,C Dias,M. I Zagalo,C Gomes,P Fernandes,M. H Santos,J. D Cabrita,S. C Modified Model of Sub-Critical Size Cranial Defect in the Rabbit
description	In medical sciences, any experimental animal model should be reproducible and adequate to the purpose of simulated human physiological response. In bone injury response research, when bone substitutes are in use, it is of primary importance that studied defects fail to heal unless treated with the tissue engineering therapy under study. This failure defines the concept of "critical size defect" (CSD) wich has different limits according to the animal species used and the location of the defect. Although this is a basic concept, when the aim of the study is to investigate the interface Bone-Biomaterial, it is of primary importance to obtain as much contact area as possible. In order to do so, we propose a modified surgical approach to the classical bi-parietal round sub-critical defect model in rabbit vault.
author	Marques,J. M Viegas,C Dias,M. I Zagalo,C Gomes,P Fernandes,M. H Santos,J. D Cabrita,S. C
author_facet	Marques,J. M Viegas,C Dias,M. I Zagalo,C Gomes,P Fernandes,M. H Santos,J. D Cabrita,S. C
author_sort	Marques,J. M
title	Modified Model of Sub-Critical Size Cranial Defect in the Rabbit
title_short	Modified Model of Sub-Critical Size Cranial Defect in the Rabbit
title_full	Modified Model of Sub-Critical Size Cranial Defect in the Rabbit
title_fullStr	Modified Model of Sub-Critical Size Cranial Defect in the Rabbit
title_full_unstemmed	Modified Model of Sub-Critical Size Cranial Defect in the Rabbit
title_sort	modified model of sub-critical size cranial defect in the rabbit
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200031
work_keys_str_mv	AT marquesjm modifiedmodelofsubcriticalsizecranialdefectintherabbit AT viegasc modifiedmodelofsubcriticalsizecranialdefectintherabbit AT diasmi modifiedmodelofsubcriticalsizecranialdefectintherabbit AT zagaloc modifiedmodelofsubcriticalsizecranialdefectintherabbit AT gomesp modifiedmodelofsubcriticalsizecranialdefectintherabbit AT fernandesmh modifiedmodelofsubcriticalsizecranialdefectintherabbit AT santosjd modifiedmodelofsubcriticalsizecranialdefectintherabbit AT cabritasc modifiedmodelofsubcriticalsizecranialdefectintherabbit
_version_	1718444695029284864

Modified Model of Sub-Critical Size Cranial Defect in the Rabbit

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