Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion

Reducing the infarct size in acute myocardial infarction is one of the most important goals driving new drug research and development. During the last two decades, many clinical studies have found cardioprotective effects of corticosteroids, but their exact role in ischemic preconditioning remains q...

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Autores principales:	Davarian,Ali, Khori,Vahid, Nayebpour,Mohsen
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Hydrocortisone Infarct size Ischemia-reperfusion model Ischemic preconditioning Serum cortisole
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300001
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spelling	oai:scielo:S0717-950220100003000012010-10-25Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-ReperfusionDavarian,AliKhori,VahidNayebpour,Mohsen Hydrocortisone Infarct size Ischemia-reperfusion model Ischemic preconditioning Serum cortisole Reducing the infarct size in acute myocardial infarction is one of the most important goals driving new drug research and development. During the last two decades, many clinical studies have found cardioprotective effects of corticosteroids, but their exact role in ischemic preconditioning remains questionable. The aim of the present study was to determine the protective effects of hydrocortisone sodium succinate on myocardial preconditioning in rabbit hearts. Twenty-four male New Zealand rabbits were divided randomly & equally in four groups: 1) control, 2) Infarct, 3) Ischemic preconditioning (IP) and 4) Hydrocortisone (HYD). The HYD group received 50mg/kg Hydrocortisone 45min before major ischemia. Serum levels of cardiac troponin-T(cTNT) and cortisole were measured before and after the protocols. Triphenyl-tetrazolium chloride staining was used to determine the infarcted area. In the present study, exogenous hydrocortisone decreased infarct size by 53% in comparison to the infarct group. Serum level of cortisole was increased in the IP and HYD groups, and was significant in the HYD group (p<0.01). An increasing trend in cortisole level was associated with a decreasing trend in infarct size and cTNT in the IP and HYD groups (p>0.01). In conclusion, we showed that hydrocortisone has cardioprotective effects when injected before the onset of myocardial infarction. In addition, we have proposed for the first time that endogenous hydrocortisone may play a role in ischemic preconditioning phenomena.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.3 20102010-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300001en10.4067/S0717-95022010000300001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hydrocortisone Infarct size Ischemia-reperfusion model Ischemic preconditioning Serum cortisole
spellingShingle	Hydrocortisone Infarct size Ischemia-reperfusion model Ischemic preconditioning Serum cortisole Davarian,Ali Khori,Vahid Nayebpour,Mohsen Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion
description	Reducing the infarct size in acute myocardial infarction is one of the most important goals driving new drug research and development. During the last two decades, many clinical studies have found cardioprotective effects of corticosteroids, but their exact role in ischemic preconditioning remains questionable. The aim of the present study was to determine the protective effects of hydrocortisone sodium succinate on myocardial preconditioning in rabbit hearts. Twenty-four male New Zealand rabbits were divided randomly & equally in four groups: 1) control, 2) Infarct, 3) Ischemic preconditioning (IP) and 4) Hydrocortisone (HYD). The HYD group received 50mg/kg Hydrocortisone 45min before major ischemia. Serum levels of cardiac troponin-T(cTNT) and cortisole were measured before and after the protocols. Triphenyl-tetrazolium chloride staining was used to determine the infarcted area. In the present study, exogenous hydrocortisone decreased infarct size by 53% in comparison to the infarct group. Serum level of cortisole was increased in the IP and HYD groups, and was significant in the HYD group (p<0.01). An increasing trend in cortisole level was associated with a decreasing trend in infarct size and cTNT in the IP and HYD groups (p>0.01). In conclusion, we showed that hydrocortisone has cardioprotective effects when injected before the onset of myocardial infarction. In addition, we have proposed for the first time that endogenous hydrocortisone may play a role in ischemic preconditioning phenomena.
author	Davarian,Ali Khori,Vahid Nayebpour,Mohsen
author_facet	Davarian,Ali Khori,Vahid Nayebpour,Mohsen
author_sort	Davarian,Ali
title	Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion
title_short	Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion
title_full	Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion
title_fullStr	Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion
title_full_unstemmed	Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion
title_sort	cardioprotective effects of exogenous and endogenous hydrocortisone in the rabbit model of ischemia-reperfusion
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300001
work_keys_str_mv	AT davarianali cardioprotectiveeffectsofexogenousandendogenoushydrocortisoneintherabbitmodelofischemiareperfusion AT khorivahid cardioprotectiveeffectsofexogenousandendogenoushydrocortisoneintherabbitmodelofischemiareperfusion AT nayebpourmohsen cardioprotectiveeffectsofexogenousandendogenoushydrocortisoneintherabbitmodelofischemiareperfusion
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Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion

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