Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study

Sucralose is a sweetener of general use in over three thousand products (beverages, foods and medical diets), with utilization currently permitted for the general population in more than 80 countries, including for women of reproductive age. There is little information on the safe use of sucralose,...

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Autores principales:	Rodero,Ademir B, Batigália,Fernando, Azoubel,Reinaldo, Moura,Arianne Assis, Rodero,Lucas de Souza, Silveira Jr,Landulfo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Sucralose Fetus Placenta Umbilical cord Weight
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300025
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spelling	oai:scielo:S0717-950220100003000252010-10-25Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental StudyRodero,Ademir BBatigália,FernandoAzoubel,ReinaldoMoura,Arianne AssisRodero,Lucas de SouzaSilveira Jr,Landulfo Sucralose Fetus Placenta Umbilical cord Weight Sucralose is a sweetener of general use in over three thousand products (beverages, foods and medical diets), with utilization currently permitted for the general population in more than 80 countries, including for women of reproductive age. There is little information on the safe use of sucralose, and experimental studies have suggested that the administration of some sweeteners, by diverse routes, retards not only fetal and placental development but also umbilical cord size. The present study aimed to estimate the fetal and placental weights and umbilical-cord length in fetuses from rat dams, after ingestion and non-ingestion of sucralose. In the treated group (5 dams), sucralose was administered (via gavage) at the dose of 30 mg/kg/day, from the 10th to 14th day of pregnancy. In the control group (5 dams), saline solution was administered, at the same dose and by the same route. On the 20th gestation day, both groups were sacrificed for weighing of the fetuses and placentas and measurement of umbilical-cord length. Mean values of fetal weight and umbilical-cord length of the treated group were significantly lower than controls (Mann-Whitney Test, p<0.001). Placental weight did not differ statistically between treated and control groups. It can be concluded from the present work that sucralose ingestion at 30 mg/kg/day, from days 10 to 14 of pregnancy, diminished fetal weight and umbilical-cord length, which suggests passage of sucralose through the placental membrane.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.3 20102010-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300025en10.4067/S0717-95022010000300025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sucralose Fetus Placenta Umbilical cord Weight
spellingShingle	Sucralose Fetus Placenta Umbilical cord Weight Rodero,Ademir B Batigália,Fernando Azoubel,Reinaldo Moura,Arianne Assis Rodero,Lucas de Souza Silveira Jr,Landulfo Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study
description	Sucralose is a sweetener of general use in over three thousand products (beverages, foods and medical diets), with utilization currently permitted for the general population in more than 80 countries, including for women of reproductive age. There is little information on the safe use of sucralose, and experimental studies have suggested that the administration of some sweeteners, by diverse routes, retards not only fetal and placental development but also umbilical cord size. The present study aimed to estimate the fetal and placental weights and umbilical-cord length in fetuses from rat dams, after ingestion and non-ingestion of sucralose. In the treated group (5 dams), sucralose was administered (via gavage) at the dose of 30 mg/kg/day, from the 10th to 14th day of pregnancy. In the control group (5 dams), saline solution was administered, at the same dose and by the same route. On the 20th gestation day, both groups were sacrificed for weighing of the fetuses and placentas and measurement of umbilical-cord length. Mean values of fetal weight and umbilical-cord length of the treated group were significantly lower than controls (Mann-Whitney Test, p<0.001). Placental weight did not differ statistically between treated and control groups. It can be concluded from the present work that sucralose ingestion at 30 mg/kg/day, from days 10 to 14 of pregnancy, diminished fetal weight and umbilical-cord length, which suggests passage of sucralose through the placental membrane.
author	Rodero,Ademir B Batigália,Fernando Azoubel,Reinaldo Moura,Arianne Assis Rodero,Lucas de Souza Silveira Jr,Landulfo
author_facet	Rodero,Ademir B Batigália,Fernando Azoubel,Reinaldo Moura,Arianne Assis Rodero,Lucas de Souza Silveira Jr,Landulfo
author_sort	Rodero,Ademir B
title	Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study
title_short	Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study
title_full	Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study
title_fullStr	Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study
title_full_unstemmed	Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study
title_sort	effects of sucralose ingestion on fetal and placental weights and umbilical-cord length: experimental study
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300025
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Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study

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