Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine Placentation

Apoptosis is a permanent and dynamic physiological process by which an organism eliminates the undesirable cells without causing an inflammatory response. The objective of this work was to study the expression of FAS, DR4 and other members of the TNF-R1 superfamily extrinsic route apoptotic receptor...

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Autores principales:	Merkis,C, Cristofolini,A, Sanchis,E, Koncurat,M
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	FAS/CD95 DR4 and TNF-R1 family Apoptosis receptors Pig placenta Placenta porcina
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300026
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spelling	oai:scielo:S0717-950220100003000262010-10-25Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine PlacentationMerkis,CCristofolini,ASanchis,EKoncurat,M FAS/CD95 DR4 and TNF-R1 family Apoptosis receptors Pig placenta Placenta porcina Apoptosis is a permanent and dynamic physiological process by which an organism eliminates the undesirable cells without causing an inflammatory response. The objective of this work was to study the expression of FAS, DR4 and other members of the TNF-R1 superfamily extrinsic route apoptotic receptors the DNA fragmentation and the cellular apoptosis in placental samples at the early, mid and late pregnancy on ± 30, ± 55 and ± 114 gestational days, respectively. We used placental histological sections of samples fixed in buffered saline formaldehyde. Immunohistochemical techniques were performed to detect the apoptotic receptors, whereas the DNA fragmentation was detected by TUNEL reaction and apoptotic cellular ultrastructure was detected by TEM conventional techniques. Apoptosis related receptors were immunolocalized in the early pig gestation and correlated with apoptosis, suggesting a role in the cellular remodelling of the placenta. At gestation day 55, apoptosis might be correlated to FAS route, but not by DR4-mediating pathway. At the end of gestation, increased apoptosis and both receptors markers were detected showing cellular death due to the extrinsic route through FAS and DR4 receptors. In conclusion, the immunolocalization of FAS and TNF R-1 receptors along the pig placental development correlates with TUNEL reaction and with apoptotic ultrastructure observed by TEM and seems to occur through different pathways along gestation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.3 20102010-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300026en10.4067/S0717-95022010000300026
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	FAS/CD95 DR4 and TNF-R1 family Apoptosis receptors Pig placenta Placenta porcina
spellingShingle	FAS/CD95 DR4 and TNF-R1 family Apoptosis receptors Pig placenta Placenta porcina Merkis,C Cristofolini,A Sanchis,E Koncurat,M Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine Placentation
description	Apoptosis is a permanent and dynamic physiological process by which an organism eliminates the undesirable cells without causing an inflammatory response. The objective of this work was to study the expression of FAS, DR4 and other members of the TNF-R1 superfamily extrinsic route apoptotic receptors the DNA fragmentation and the cellular apoptosis in placental samples at the early, mid and late pregnancy on ± 30, ± 55 and ± 114 gestational days, respectively. We used placental histological sections of samples fixed in buffered saline formaldehyde. Immunohistochemical techniques were performed to detect the apoptotic receptors, whereas the DNA fragmentation was detected by TUNEL reaction and apoptotic cellular ultrastructure was detected by TEM conventional techniques. Apoptosis related receptors were immunolocalized in the early pig gestation and correlated with apoptosis, suggesting a role in the cellular remodelling of the placenta. At gestation day 55, apoptosis might be correlated to FAS route, but not by DR4-mediating pathway. At the end of gestation, increased apoptosis and both receptors markers were detected showing cellular death due to the extrinsic route through FAS and DR4 receptors. In conclusion, the immunolocalization of FAS and TNF R-1 receptors along the pig placental development correlates with TUNEL reaction and with apoptotic ultrastructure observed by TEM and seems to occur through different pathways along gestation.
author	Merkis,C Cristofolini,A Sanchis,E Koncurat,M
author_facet	Merkis,C Cristofolini,A Sanchis,E Koncurat,M
author_sort	Merkis,C
title	Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine Placentation
title_short	Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine Placentation
title_full	Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine Placentation
title_fullStr	Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine Placentation
title_full_unstemmed	Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine Placentation
title_sort	expression of death cellular receptors fas/cd95 and dr4 during porcine placentation
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300026
work_keys_str_mv	AT merkisc expressionofdeathcellularreceptorsfascd95anddr4duringporcineplacentation AT cristofolinia expressionofdeathcellularreceptorsfascd95anddr4duringporcineplacentation AT sanchise expressionofdeathcellularreceptorsfascd95anddr4duringporcineplacentation AT koncuratm expressionofdeathcellularreceptorsfascd95anddr4duringporcineplacentation
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Expression of Death Cellular Receptors FAS/CD95 and DR4 During Porcine Placentation

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