Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage

We investigated the reproductive damage and teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, which received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. In rats treated with the mixture the numb...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Arteaga-Martínez,Manuel, García-Peláez,Isabel, Aguirre-Luna,Oswaldo M, Saavedra-Ontiveros,Dolores
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Ethylene glycol Glycol ethers Methyl cellosolve Rat fetuses Teratogenesis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400016
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022010000400016
record_format	dspace
spelling	oai:scielo:S0717-950220100004000162011-03-31Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive DamageArteaga-Martínez,ManuelGarcía-Peláez,IsabelAguirre-Luna,Oswaldo MSaavedra-Ontiveros,Dolores Ethylene glycol Glycol ethers Methyl cellosolve Rat fetuses Teratogenesis We investigated the reproductive damage and teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, which received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing reproductive damage, external fetal abnormalities, growth delay, and increased fetal death.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.4 20102010-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400016en10.4067/S0717-95022010000400016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ethylene glycol Glycol ethers Methyl cellosolve Rat fetuses Teratogenesis
spellingShingle	Ethylene glycol Glycol ethers Methyl cellosolve Rat fetuses Teratogenesis Arteaga-Martínez,Manuel García-Peláez,Isabel Aguirre-Luna,Oswaldo M Saavedra-Ontiveros,Dolores Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage
description	We investigated the reproductive damage and teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, which received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing reproductive damage, external fetal abnormalities, growth delay, and increased fetal death.
author	Arteaga-Martínez,Manuel García-Peláez,Isabel Aguirre-Luna,Oswaldo M Saavedra-Ontiveros,Dolores
author_facet	Arteaga-Martínez,Manuel García-Peláez,Isabel Aguirre-Luna,Oswaldo M Saavedra-Ontiveros,Dolores
author_sort	Arteaga-Martínez,Manuel
title	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage
title_short	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage
title_full	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage
title_fullStr	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage
title_full_unstemmed	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage
title_sort	teratogenic effect of ethylene glycol-methyl cellosolve mixture in rats.: i. reproductive damage
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400016
work_keys_str_mv	AT arteagamartinezmanuel teratogeniceffectofethyleneglycolmethylcellosolvemixtureinratsireproductivedamage AT garciapelaezisabel teratogeniceffectofethyleneglycolmethylcellosolvemixtureinratsireproductivedamage AT aguirrelunaoswaldom teratogeniceffectofethyleneglycolmethylcellosolvemixtureinratsireproductivedamage AT saavedraontiverosdolores teratogeniceffectofethyleneglycolmethylcellosolvemixtureinratsireproductivedamage
_version_	1718444710277677056

Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage

Ejemplares similares