Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities

We investigated the teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, that received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. Multivariate analysis and Post-Hoc Bonferroni tests were used and...

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Autores principales:	García-Peláez,Isabel, Aguirre-Luna,Oswaldo M, Saavedra-Ontiveros,Dolores, Arteaga-Martínez,Manuel
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Ethylene glycol Glycol ethers Methyl cellosolve Rat fetuses Teratogenesis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400030
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spelling	oai:scielo:S0717-950220100004000302011-03-31Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb AbnormalitiesGarcía-Peláez,IsabelAguirre-Luna,Oswaldo MSaavedra-Ontiveros,DoloresArteaga-Martínez,Manuel Ethylene glycol Glycol ethers Methyl cellosolve Rat fetuses Teratogenesis We investigated the teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, that received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. Multivariate analysis and Post-Hoc Bonferroni tests were used and relative risk and attributable fraction were calculated. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. Abnormalities consisted mainly in atypical craniofacial morphology, protruding tongue, edema, signs of growth delay and shorter limbs, their frequency and severity increased at higher concentrations of the mixture. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing external fetal abnormalities, growth delay, and increased fetal death.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.4 20102010-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400030en10.4067/S0717-95022010000400030
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ethylene glycol Glycol ethers Methyl cellosolve Rat fetuses Teratogenesis
spellingShingle	Ethylene glycol Glycol ethers Methyl cellosolve Rat fetuses Teratogenesis García-Peláez,Isabel Aguirre-Luna,Oswaldo M Saavedra-Ontiveros,Dolores Arteaga-Martínez,Manuel Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities
description	We investigated the teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, that received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. Multivariate analysis and Post-Hoc Bonferroni tests were used and relative risk and attributable fraction were calculated. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. Abnormalities consisted mainly in atypical craniofacial morphology, protruding tongue, edema, signs of growth delay and shorter limbs, their frequency and severity increased at higher concentrations of the mixture. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing external fetal abnormalities, growth delay, and increased fetal death.
author	García-Peláez,Isabel Aguirre-Luna,Oswaldo M Saavedra-Ontiveros,Dolores Arteaga-Martínez,Manuel
author_facet	García-Peláez,Isabel Aguirre-Luna,Oswaldo M Saavedra-Ontiveros,Dolores Arteaga-Martínez,Manuel
author_sort	García-Peláez,Isabel
title	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities
title_short	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities
title_full	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities
title_fullStr	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities
title_full_unstemmed	Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities
title_sort	teratogenic effect of ethylene glycol-methyl cellosolve mixture in rats: ii. craniofacial and limb abnormalities
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400030
work_keys_str_mv	AT garciapelaezisabel teratogeniceffectofethyleneglycolmethylcellosolvemixtureinratsiicraniofacialandlimbabnormalities AT aguirrelunaoswaldom teratogeniceffectofethyleneglycolmethylcellosolvemixtureinratsiicraniofacialandlimbabnormalities AT saavedraontiverosdolores teratogeniceffectofethyleneglycolmethylcellosolvemixtureinratsiicraniofacialandlimbabnormalities AT arteagamartinezmanuel teratogeniceffectofethyleneglycolmethylcellosolvemixtureinratsiicraniofacialandlimbabnormalities
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Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities

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