Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles

Engineered nanoparticles are designed to perform specific functions and therefore have specific properties that could potentially be harmful. Nanoparticles such as titanium dioxide have the potential to become transparent and are therefore widely used in cosmetic products and sunscreen. Research on...

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Autores principales:	Oosthuizen,Maria Aletta, Pretorius,Etheresia, Oberholzer,Hester Magdalena, van der Spuy,Wendy Jeannette
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Nanoparticles TiO2 Platelets Fibrin BALB/c murine model
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400044
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spelling	oai:scielo:S0717-950220100004000442011-03-31Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium NanoparticlesOosthuizen,Maria AlettaPretorius,EtheresiaOberholzer,Hester Magdalenavan der Spuy,Wendy Jeannette Nanoparticles TiO2 Platelets Fibrin BALB/c murine model Engineered nanoparticles are designed to perform specific functions and therefore have specific properties that could potentially be harmful. Nanoparticles such as titanium dioxide have the potential to become transparent and are therefore widely used in cosmetic products and sunscreen. Research on the toxicity of nanoparticles is of utmost importance and numerous in vitro studies have shown that some of these particles could have adverse health effects. The current study aimed to investigate the in vivo effects of two different titanium nanoparticles at two different concentrations after inhalation by experimental BALB/c mice. This was done to determine whether these particles will cause an inflammatory reaction, visible as alterations in platelet and fibrin ultrastructure. Mice were divided into five experimental groups comprising of a control group, high and low concentration groups exposed to the spherical-shaped particles, as well as high and low concentration groups exposed to the rod-shaped particles. The ultrastructure of the fibrin networks and platelet aggregates of these experimental groups were investigated and compared to that of controls. Results indicated that the fibrin networks of the exposed animals have a net-like covering over the major fibres, typical to that found in animals with inflammation. It can therefore be concluded that the nanoparticles used in this study may have the potential to cause an inflammatory reaction, affecting the haemostatic physiology.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.4 20102010-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400044en10.4067/S0717-95022010000400044
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Nanoparticles TiO2 Platelets Fibrin BALB/c murine model
spellingShingle	Nanoparticles TiO2 Platelets Fibrin BALB/c murine model Oosthuizen,Maria Aletta Pretorius,Etheresia Oberholzer,Hester Magdalena van der Spuy,Wendy Jeannette Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles
description	Engineered nanoparticles are designed to perform specific functions and therefore have specific properties that could potentially be harmful. Nanoparticles such as titanium dioxide have the potential to become transparent and are therefore widely used in cosmetic products and sunscreen. Research on the toxicity of nanoparticles is of utmost importance and numerous in vitro studies have shown that some of these particles could have adverse health effects. The current study aimed to investigate the in vivo effects of two different titanium nanoparticles at two different concentrations after inhalation by experimental BALB/c mice. This was done to determine whether these particles will cause an inflammatory reaction, visible as alterations in platelet and fibrin ultrastructure. Mice were divided into five experimental groups comprising of a control group, high and low concentration groups exposed to the spherical-shaped particles, as well as high and low concentration groups exposed to the rod-shaped particles. The ultrastructure of the fibrin networks and platelet aggregates of these experimental groups were investigated and compared to that of controls. Results indicated that the fibrin networks of the exposed animals have a net-like covering over the major fibres, typical to that found in animals with inflammation. It can therefore be concluded that the nanoparticles used in this study may have the potential to cause an inflammatory reaction, affecting the haemostatic physiology.
author	Oosthuizen,Maria Aletta Pretorius,Etheresia Oberholzer,Hester Magdalena van der Spuy,Wendy Jeannette
author_facet	Oosthuizen,Maria Aletta Pretorius,Etheresia Oberholzer,Hester Magdalena van der Spuy,Wendy Jeannette
author_sort	Oosthuizen,Maria Aletta
title	Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles
title_short	Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles
title_full	Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles
title_fullStr	Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles
title_full_unstemmed	Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles
title_sort	ultrastructural analyses of platelets and fibrin networks in balb/c mice after inhalation of spherical and rod-shaped titanium nanoparticles
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400044
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Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles

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