Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino Rat

Decoction of Ficus sycomorus stem bark is used to treat infertility involving low sperm counts, but the reproductive risk associated with its use is uncertain. The aqueous stem-bark extract was orally administered at 200-600 mg/kg for 30 days to post-pubertal growing albino rats. Within the period,...

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Autores principales:	Igbokwe,N. A, Igbokwe,I. O, Sandabe,U. K
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2010
Materias:	Ficus sycomorus extract Testicular size Testicular histopathology Spermatogenesis Male reproductive risk
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400052
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spelling	oai:scielo:S0717-950220100004000522011-03-31Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino RatIgbokwe,N. AIgbokwe,I. OSandabe,U. K Ficus sycomorus extract Testicular size Testicular histopathology Spermatogenesis Male reproductive risk Decoction of Ficus sycomorus stem bark is used to treat infertility involving low sperm counts, but the reproductive risk associated with its use is uncertain. The aqueous stem-bark extract was orally administered at 200-600 mg/kg for 30 days to post-pubertal growing albino rats. Within the period, the live body weights, scrotal diameters and testicular size parameters were estimated. The mean live body weight, scrotal diameter of the control and treated rats significantly (p<0.05) increased as the animals grew, but the treatment did not significantly (p>0.05) affect the parameters. There were no significant (p>0.05) variations in mean testicular size parameters in treated and control rats, and no dose-dependent nor time-dependent effects occurred. Sections of the testes of the treated animals showed active spermatogenesis in the seminiferous tubules with no apparent histological lesions. It is concluded that the use of the crude extract of the Ficus sycomorus within our dose range portends minimal male reproductive risk and underscores the need to study its pro-spermatic effect.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.4 20102010-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400052en10.4067/S0717-95022010000400052
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ficus sycomorus extract Testicular size Testicular histopathology Spermatogenesis Male reproductive risk
spellingShingle	Ficus sycomorus extract Testicular size Testicular histopathology Spermatogenesis Male reproductive risk Igbokwe,N. A Igbokwe,I. O Sandabe,U. K Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino Rat
description	Decoction of Ficus sycomorus stem bark is used to treat infertility involving low sperm counts, but the reproductive risk associated with its use is uncertain. The aqueous stem-bark extract was orally administered at 200-600 mg/kg for 30 days to post-pubertal growing albino rats. Within the period, the live body weights, scrotal diameters and testicular size parameters were estimated. The mean live body weight, scrotal diameter of the control and treated rats significantly (p<0.05) increased as the animals grew, but the treatment did not significantly (p>0.05) affect the parameters. There were no significant (p>0.05) variations in mean testicular size parameters in treated and control rats, and no dose-dependent nor time-dependent effects occurred. Sections of the testes of the treated animals showed active spermatogenesis in the seminiferous tubules with no apparent histological lesions. It is concluded that the use of the crude extract of the Ficus sycomorus within our dose range portends minimal male reproductive risk and underscores the need to study its pro-spermatic effect.
author	Igbokwe,N. A Igbokwe,I. O Sandabe,U. K
author_facet	Igbokwe,N. A Igbokwe,I. O Sandabe,U. K
author_sort	Igbokwe,N. A
title	Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino Rat
title_short	Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino Rat
title_full	Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino Rat
title_fullStr	Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino Rat
title_full_unstemmed	Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino Rat
title_sort	effect of prolonged oral administration of aqueous ficus sycomorus stem-bark extract on testicular size of growing albino rat
publisher	Sociedad Chilena de Anatomía
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400052
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Effect of Prolonged Oral Administration of Aqueous Ficus sycomorus Stem-bark Extract on Testicular Size of Growing Albino Rat

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