Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study

In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvas...

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Autores principales:	Aktas,Ayfer, Serhan Tasdemir,M, Cudi Tuncer,M, Nergiz,Yusuf, Akkus,Murat, Bagriyanik,Hüsnü Alper
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Kidney Wistar-albino rat Statins Atorvastatin Ultrastructural
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100025
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spelling	oai:scielo:S0717-950220110001000252011-09-21Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic StudyAktas,AyferSerhan Tasdemir,MCudi Tuncer,MNergiz,YusufAkkus,MuratBagriyanik,Hüsnü Alper Kidney Wistar-albino rat Statins Atorvastatin Ultrastructural In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty adult male Wistar albino rats (200250 g) were randomly divided into 4 groups of ten rats each (A1, A2, A3 and Control). Three different doses of atorvastatin were used to determine the effects on kidney tissues during 90 day period. The kidneys of A1 (0.1-mg group), A2 (0.5-mg group) and A3 (1-mg group) group were excised and the tissues were examined after the 90 days by transmission electron microscopy. Despite increasing the dose of atorvastatin intake, the histological structures of atorvastatin groups were appeared normal in the same period. In conclusion, long-term use of atorvastatin was not found to have an adverse effect on kidney tissue.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.1 20112011-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100025en10.4067/S0717-95022011000100025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Kidney Wistar-albino rat Statins Atorvastatin Ultrastructural
spellingShingle	Kidney Wistar-albino rat Statins Atorvastatin Ultrastructural Aktas,Ayfer Serhan Tasdemir,M Cudi Tuncer,M Nergiz,Yusuf Akkus,Murat Bagriyanik,Hüsnü Alper Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
description	In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty adult male Wistar albino rats (200250 g) were randomly divided into 4 groups of ten rats each (A1, A2, A3 and Control). Three different doses of atorvastatin were used to determine the effects on kidney tissues during 90 day period. The kidneys of A1 (0.1-mg group), A2 (0.5-mg group) and A3 (1-mg group) group were excised and the tissues were examined after the 90 days by transmission electron microscopy. Despite increasing the dose of atorvastatin intake, the histological structures of atorvastatin groups were appeared normal in the same period. In conclusion, long-term use of atorvastatin was not found to have an adverse effect on kidney tissue.
author	Aktas,Ayfer Serhan Tasdemir,M Cudi Tuncer,M Nergiz,Yusuf Akkus,Murat Bagriyanik,Hüsnü Alper
author_facet	Aktas,Ayfer Serhan Tasdemir,M Cudi Tuncer,M Nergiz,Yusuf Akkus,Murat Bagriyanik,Hüsnü Alper
author_sort	Aktas,Ayfer
title	Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
title_short	Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
title_full	Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
title_fullStr	Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
title_full_unstemmed	Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
title_sort	atorvastatin has no effects on kidney tissues of wistar albino rats in the long-term intake: an electron microscopic study
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100025
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Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study

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