Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats

The aim of the study was quantifying and morphologically analyzing the myenteric neurons of the small and large gastric curvatures of the glandular stomach of rats infected the tachyzoites of the Toxoplasma gondii for 30 days. Ten male rats were assigned into two groups: Control Group (CG) and Exper...

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Autores principales:	Alves,Marcelo Sardeto, Silva,Aristeu Vieira da, Bianchi,Larissa Renata de Oliveira, Araújo,Eduardo José de Almeida, Sant'Ana,Débora de Mello Gonçales
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Stomach Toxoplasmosis Enteric nervous system Myenteric plexus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100048
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spelling	oai:scielo:S0717-950220110001000482011-09-21Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in RatsAlves,Marcelo SardetoSilva,Aristeu Vieira daBianchi,Larissa Renata de OliveiraAraújo,Eduardo José de AlmeidaSant'Ana,Débora de Mello Gonçales Stomach Toxoplasmosis Enteric nervous system Myenteric plexus The aim of the study was quantifying and morphologically analyzing the myenteric neurons of the small and large gastric curvatures of the glandular stomach of rats infected the tachyzoites of the Toxoplasma gondii for 30 days. Ten male rats were assigned into two groups: Control Group (CG) and Experimental Group (EG). The animals from the CG received saline solution orally whereas the EG animals received 104 tachyzoites of the T. gondii genotype III strain (BTU II). After 30 days, euthanasia was conducted for the removal of the stomach, which was dissected under the stereomicroscope for removal of the tunica mucosa and the tela submucosa. Whole mounts were stained with Giemsa. Quantification of the myenteric neurons was conducted by using a 40X-objective microscope in 40 microscopic fields for the region of the small gastric curvature and 40 fields for the large gastric curvature of the glandular stomach of the animals from both groups. The cell body of 50 myenteric neurons from each region was measured for each animal. Chronic experimental infection caused by the genotype III strain of Toxoplasma gondii was verified to reduce myenteric neuron density only in the small gastric curvature region of the glandular stomach, not resulting in significant changes in the size of the neurons.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.1 20112011-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100048en10.4067/S0717-95022011000100048
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Stomach Toxoplasmosis Enteric nervous system Myenteric plexus
spellingShingle	Stomach Toxoplasmosis Enteric nervous system Myenteric plexus Alves,Marcelo Sardeto Silva,Aristeu Vieira da Bianchi,Larissa Renata de Oliveira Araújo,Eduardo José de Almeida Sant'Ana,Débora de Mello Gonçales Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats
description	The aim of the study was quantifying and morphologically analyzing the myenteric neurons of the small and large gastric curvatures of the glandular stomach of rats infected the tachyzoites of the Toxoplasma gondii for 30 days. Ten male rats were assigned into two groups: Control Group (CG) and Experimental Group (EG). The animals from the CG received saline solution orally whereas the EG animals received 104 tachyzoites of the T. gondii genotype III strain (BTU II). After 30 days, euthanasia was conducted for the removal of the stomach, which was dissected under the stereomicroscope for removal of the tunica mucosa and the tela submucosa. Whole mounts were stained with Giemsa. Quantification of the myenteric neurons was conducted by using a 40X-objective microscope in 40 microscopic fields for the region of the small gastric curvature and 40 fields for the large gastric curvature of the glandular stomach of the animals from both groups. The cell body of 50 myenteric neurons from each region was measured for each animal. Chronic experimental infection caused by the genotype III strain of Toxoplasma gondii was verified to reduce myenteric neuron density only in the small gastric curvature region of the glandular stomach, not resulting in significant changes in the size of the neurons.
author	Alves,Marcelo Sardeto Silva,Aristeu Vieira da Bianchi,Larissa Renata de Oliveira Araújo,Eduardo José de Almeida Sant'Ana,Débora de Mello Gonçales
author_facet	Alves,Marcelo Sardeto Silva,Aristeu Vieira da Bianchi,Larissa Renata de Oliveira Araújo,Eduardo José de Almeida Sant'Ana,Débora de Mello Gonçales
author_sort	Alves,Marcelo Sardeto
title	Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats
title_short	Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats
title_full	Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats
title_fullStr	Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats
title_full_unstemmed	Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats
title_sort	toxoplasma gondii induces death of gastric myenteric neurons in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100048
work_keys_str_mv	AT alvesmarcelosardeto toxoplasmagondiiinducesdeathofgastricmyentericneuronsinrats AT silvaaristeuvieirada toxoplasmagondiiinducesdeathofgastricmyentericneuronsinrats AT bianchilarissarenatadeoliveira toxoplasmagondiiinducesdeathofgastricmyentericneuronsinrats AT araujoeduardojosedealmeida toxoplasmagondiiinducesdeathofgastricmyentericneuronsinrats AT santanadeborademellogoncales toxoplasmagondiiinducesdeathofgastricmyentericneuronsinrats
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Toxoplasma gondii Induces Death of Gastric Myenteric Neurons in Rats

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