Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley Rats

Considering the size of some nuclei and area, sex hormones control the sexual development of the brain. The sexual development of the brain can also be influenced by environmental stress. This study aimed to clear the effect of prenatal water deprivation on the development of sexual dimorphic nucleu...

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Autores principales:	Chehreie,Shima, Sadri,Soheil, Khazaei,Mozafar, Ghanbari,Ali, Ayubian,Mahmood, Amiri,Sara
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Apoptosis Rat SDN nucleus Stress TUNEL
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200032
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spelling	oai:scielo:S0717-950220110002000322011-07-22Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley RatsChehreie,ShimaSadri,SoheilKhazaei,MozafarGhanbari,AliAyubian,MahmoodAmiri,Sara Apoptosis Rat SDN nucleus Stress TUNEL Considering the size of some nuclei and area, sex hormones control the sexual development of the brain. The sexual development of the brain can also be influenced by environmental stress. This study aimed to clear the effect of prenatal water deprivation on the development of sexual dimorphic nucleus (SDN) of the brain. In this research, pregnant rats were divided into two groups (control and treated). For the treated animals, water was removed from the ewes for 48 h at the end of third trimester of gestation (19-21 days). TUNEL staining was used for detection of apoptosis in paraffin embedded diencephalon selected sections. The ratio of apoptotic cells to non- apoptotic ones was calculated as apoptotic index. Differences of apoptotic index and serum testosterone were examined for statistical significance using Paired T- test (p<0.05). The apoptotic index was 0.0160±.01174% for control and 0.1870±.02541 % for treated groups. The concentration of serum testosterone was 22.4±1.3 for control and 13.37±3.3 for treated groups. Prenatal water deprivation induces apoptosis in developing SDN nucleus of male rats that is derived by reducing the concentration of serum testosterone. The study shows the importance of low concentration acting testosterone for development of SDN nucleus that can be affected by environmental stress.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.2 20112011-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200032en10.4067/S0717-95022011000200032
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Apoptosis Rat SDN nucleus Stress TUNEL
spellingShingle	Apoptosis Rat SDN nucleus Stress TUNEL Chehreie,Shima Sadri,Soheil Khazaei,Mozafar Ghanbari,Ali Ayubian,Mahmood Amiri,Sara Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley Rats
description	Considering the size of some nuclei and area, sex hormones control the sexual development of the brain. The sexual development of the brain can also be influenced by environmental stress. This study aimed to clear the effect of prenatal water deprivation on the development of sexual dimorphic nucleus (SDN) of the brain. In this research, pregnant rats were divided into two groups (control and treated). For the treated animals, water was removed from the ewes for 48 h at the end of third trimester of gestation (19-21 days). TUNEL staining was used for detection of apoptosis in paraffin embedded diencephalon selected sections. The ratio of apoptotic cells to non- apoptotic ones was calculated as apoptotic index. Differences of apoptotic index and serum testosterone were examined for statistical significance using Paired T- test (p<0.05). The apoptotic index was 0.0160±.01174% for control and 0.1870±.02541 % for treated groups. The concentration of serum testosterone was 22.4±1.3 for control and 13.37±3.3 for treated groups. Prenatal water deprivation induces apoptosis in developing SDN nucleus of male rats that is derived by reducing the concentration of serum testosterone. The study shows the importance of low concentration acting testosterone for development of SDN nucleus that can be affected by environmental stress.
author	Chehreie,Shima Sadri,Soheil Khazaei,Mozafar Ghanbari,Ali Ayubian,Mahmood Amiri,Sara
author_facet	Chehreie,Shima Sadri,Soheil Khazaei,Mozafar Ghanbari,Ali Ayubian,Mahmood Amiri,Sara
author_sort	Chehreie,Shima
title	Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley Rats
title_short	Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley Rats
title_full	Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley Rats
title_fullStr	Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley Rats
title_full_unstemmed	Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley Rats
title_sort	prenatal water deprivation induces apoptosis in sexual dimorphic nucleus of the brain of male new born sprague-dawley rats
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200032
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Prenatal Water Deprivation Induces Apoptosis in Sexual Dimorphic Nucleus of the Brain of Male New Born Sprague-Dawley Rats

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