Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars

This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizog...

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Autores principales: Oliveira,David Moraes de, Silveira,Márcia Maria Ferreira da, Andrade,Emanuel Sávio de Souza, Sobral,Ana Paula Veras, Martins-Filho,Paulo Ricardo Saquete, Santos,Thiago de Santana, Oliveira,Patrícia Leimig Amorim de
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2011
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200037
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spelling oai:scielo:S0717-950220110002000372011-07-22Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third MolarsOliveira,David Moraes deSilveira,Márcia Maria Ferreira daAndrade,Emanuel Sávio de SouzaSobral,Ana Paula VerasMartins-Filho,Paulo Ricardo SaqueteSantos,Thiago de SantanaOliveira,Patrícia Leimig Amorim de Immunohistochemistry Dental Sac Third Molar This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferating was determined by using immunohistochemical labeling. Statistical analysis was performed using the Fisher exact test. Of the 105 dental follicles collected, 6 were PCNA-positive ( 6%). The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PCNA, as well as those with proliferative remnants of odontogenic epithelium. In conclusion, this study shows that dental follicles at this stage of development have low proliferative potential, but suggests that squamous metaplasia, hyperplasia of the epithelial lining and presence of proliferative odontogenic epithelial rests in the connective tissue may be early signs of developing lesions of odontogenic origin.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.2 20112011-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200037en10.4067/S0717-95022011000200037
institution Scielo Chile
collection Scielo Chile
language English
topic Immunohistochemistry
Dental Sac
Third Molar
spellingShingle Immunohistochemistry
Dental Sac
Third Molar
Oliveira,David Moraes de
Silveira,Márcia Maria Ferreira da
Andrade,Emanuel Sávio de Souza
Sobral,Ana Paula Veras
Martins-Filho,Paulo Ricardo Saquete
Santos,Thiago de Santana
Oliveira,Patrícia Leimig Amorim de
Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars
description This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferating was determined by using immunohistochemical labeling. Statistical analysis was performed using the Fisher exact test. Of the 105 dental follicles collected, 6 were PCNA-positive ( 6%). The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PCNA, as well as those with proliferative remnants of odontogenic epithelium. In conclusion, this study shows that dental follicles at this stage of development have low proliferative potential, but suggests that squamous metaplasia, hyperplasia of the epithelial lining and presence of proliferative odontogenic epithelial rests in the connective tissue may be early signs of developing lesions of odontogenic origin.
author Oliveira,David Moraes de
Silveira,Márcia Maria Ferreira da
Andrade,Emanuel Sávio de Souza
Sobral,Ana Paula Veras
Martins-Filho,Paulo Ricardo Saquete
Santos,Thiago de Santana
Oliveira,Patrícia Leimig Amorim de
author_facet Oliveira,David Moraes de
Silveira,Márcia Maria Ferreira da
Andrade,Emanuel Sávio de Souza
Sobral,Ana Paula Veras
Martins-Filho,Paulo Ricardo Saquete
Santos,Thiago de Santana
Oliveira,Patrícia Leimig Amorim de
author_sort Oliveira,David Moraes de
title Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars
title_short Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars
title_full Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars
title_fullStr Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars
title_full_unstemmed Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars
title_sort immunohistochemical analysis of proliferating cell nuclear antigen (pcna) in dental follicles of impacted third molars
publisher Sociedad Chilena de Anatomía
publishDate 2011
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200037
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