Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars
This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizog...
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Sociedad Chilena de Anatomía
2011
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oai:scielo:S0717-950220110002000372011-07-22Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third MolarsOliveira,David Moraes deSilveira,Márcia Maria Ferreira daAndrade,Emanuel Sávio de SouzaSobral,Ana Paula VerasMartins-Filho,Paulo Ricardo SaqueteSantos,Thiago de SantanaOliveira,Patrícia Leimig Amorim de Immunohistochemistry Dental Sac Third Molar This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferating was determined by using immunohistochemical labeling. Statistical analysis was performed using the Fisher exact test. Of the 105 dental follicles collected, 6 were PCNA-positive ( 6%). The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PCNA, as well as those with proliferative remnants of odontogenic epithelium. In conclusion, this study shows that dental follicles at this stage of development have low proliferative potential, but suggests that squamous metaplasia, hyperplasia of the epithelial lining and presence of proliferative odontogenic epithelial rests in the connective tissue may be early signs of developing lesions of odontogenic origin.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.2 20112011-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200037en10.4067/S0717-95022011000200037 |
institution |
Scielo Chile |
collection |
Scielo Chile |
language |
English |
topic |
Immunohistochemistry Dental Sac Third Molar |
spellingShingle |
Immunohistochemistry Dental Sac Third Molar Oliveira,David Moraes de Silveira,Márcia Maria Ferreira da Andrade,Emanuel Sávio de Souza Sobral,Ana Paula Veras Martins-Filho,Paulo Ricardo Saquete Santos,Thiago de Santana Oliveira,Patrícia Leimig Amorim de Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars |
description |
This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferating was determined by using immunohistochemical labeling. Statistical analysis was performed using the Fisher exact test. Of the 105 dental follicles collected, 6 were PCNA-positive ( 6%). The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PCNA, as well as those with proliferative remnants of odontogenic epithelium. In conclusion, this study shows that dental follicles at this stage of development have low proliferative potential, but suggests that squamous metaplasia, hyperplasia of the epithelial lining and presence of proliferative odontogenic epithelial rests in the connective tissue may be early signs of developing lesions of odontogenic origin. |
author |
Oliveira,David Moraes de Silveira,Márcia Maria Ferreira da Andrade,Emanuel Sávio de Souza Sobral,Ana Paula Veras Martins-Filho,Paulo Ricardo Saquete Santos,Thiago de Santana Oliveira,Patrícia Leimig Amorim de |
author_facet |
Oliveira,David Moraes de Silveira,Márcia Maria Ferreira da Andrade,Emanuel Sávio de Souza Sobral,Ana Paula Veras Martins-Filho,Paulo Ricardo Saquete Santos,Thiago de Santana Oliveira,Patrícia Leimig Amorim de |
author_sort |
Oliveira,David Moraes de |
title |
Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars |
title_short |
Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars |
title_full |
Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars |
title_fullStr |
Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars |
title_full_unstemmed |
Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars |
title_sort |
immunohistochemical analysis of proliferating cell nuclear antigen (pcna) in dental follicles of impacted third molars |
publisher |
Sociedad Chilena de Anatomía |
publishDate |
2011 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200037 |
work_keys_str_mv |
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1718444732981444608 |