Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom

Since the 1970s, There have been studies of the venom of Latrodectus sp. spiders, in particular the latrotoxin (LTX) of Latrodectus mactans. Many of the studies were aimed at understanding the action of the venom on the muscular system. Now accepted that LTX is able to generate a calcium-permeable m...

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Autores principales:	Navarrete Gómez,Patricia, Ormeño,David, Miranda,Antonio, Sánchez Gutiérrez,Raúl, Romero Mejía,Fernando, Parodi Rivera,Jorge
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Latrodectus venom Oocytes Neurons Spermatozoa Contraceptive
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300012
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spelling	oai:scielo:S0717-950220110003000122012-06-11Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus VenomNavarrete Gómez,PatriciaOrmeño,DavidMiranda,AntonioSánchez Gutiérrez,RaúlRomero Mejía,FernandoParodi Rivera,Jorge Latrodectus venom Oocytes Neurons Spermatozoa Contraceptive Since the 1970s, There have been studies of the venom of Latrodectus sp. spiders, in particular the latrotoxin (LTX) of Latrodectus mactans. Many of the studies were aimed at understanding the action of the venom on the muscular system. Now accepted that LTX is able to generate a calcium-permeable membrane pore and modulate the release of synaptic vesicles that activate a receptor and induce cellular changes. Interestingly, when work began with venom obtained from the Latrodectus sp present in Chile, it generated clinical indications similar to the bite of this spider in another country, with some differences in intensity. The purpose of the first studies was to understand the systemic mechanisms of this venom, and other active compounds were studied for biological interest. It was found that these molecules are capable of causing systemic effects such as changes in muscle contraction; of generating vascular relaxation and synaptic and cellular modulation; and of altering potassium conductance channels. Based on this evidence, we suggested biotechnological applications to characterize low molecular-weight compounds obtained from the Chilean Latrodectus venom and exploring the effects on the electrophysiology in oocytes and neurons, and the contraceptive effect on spermatozoa.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.3 20112011-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300012en10.4067/S0717-95022011000300012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Latrodectus venom Oocytes Neurons Spermatozoa Contraceptive
spellingShingle	Latrodectus venom Oocytes Neurons Spermatozoa Contraceptive Navarrete Gómez,Patricia Ormeño,David Miranda,Antonio Sánchez Gutiérrez,Raúl Romero Mejía,Fernando Parodi Rivera,Jorge Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom
description	Since the 1970s, There have been studies of the venom of Latrodectus sp. spiders, in particular the latrotoxin (LTX) of Latrodectus mactans. Many of the studies were aimed at understanding the action of the venom on the muscular system. Now accepted that LTX is able to generate a calcium-permeable membrane pore and modulate the release of synaptic vesicles that activate a receptor and induce cellular changes. Interestingly, when work began with venom obtained from the Latrodectus sp present in Chile, it generated clinical indications similar to the bite of this spider in another country, with some differences in intensity. The purpose of the first studies was to understand the systemic mechanisms of this venom, and other active compounds were studied for biological interest. It was found that these molecules are capable of causing systemic effects such as changes in muscle contraction; of generating vascular relaxation and synaptic and cellular modulation; and of altering potassium conductance channels. Based on this evidence, we suggested biotechnological applications to characterize low molecular-weight compounds obtained from the Chilean Latrodectus venom and exploring the effects on the electrophysiology in oocytes and neurons, and the contraceptive effect on spermatozoa.
author	Navarrete Gómez,Patricia Ormeño,David Miranda,Antonio Sánchez Gutiérrez,Raúl Romero Mejía,Fernando Parodi Rivera,Jorge
author_facet	Navarrete Gómez,Patricia Ormeño,David Miranda,Antonio Sánchez Gutiérrez,Raúl Romero Mejía,Fernando Parodi Rivera,Jorge
author_sort	Navarrete Gómez,Patricia
title	Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom
title_short	Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom
title_full	Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom
title_fullStr	Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom
title_full_unstemmed	Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom
title_sort	molecular characterization, electrophysiological and contraceptive effect of chilean latrodectus venom
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300012
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Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom

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