Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits

Sudan-positive atherosclerotic lesions preferentially occur at downstream and lateral margins of arterial branch ostia in human neonates and weanling rabbits but tend to develop at lateral and upstream margins in old subjects. We investigated (i) the pattern of sudanophilic lesions at aortic ostia o...

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Autores principales:	Shahid,Uzma, Butt,Shadab Ahmed, Zareen,Nusrat
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Sudanophilic lesions Aorta Ostia Rabbits
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300013
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spelling	oai:scielo:S0717-950220110003000132012-06-11Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult RabbitsShahid,UzmaButt,Shadab AhmedZareen,Nusrat Sudanophilic lesions Aorta Ostia Rabbits Sudan-positive atherosclerotic lesions preferentially occur at downstream and lateral margins of arterial branch ostia in human neonates and weanling rabbits but tend to develop at lateral and upstream margins in old subjects. We investigated (i) the pattern of sudanophilic lesions at aortic ostia of cholesterol-fed adult rabbits and (ii) determined any differences in lesion distribution between descending thoracic and abdominal aorta. Ten adult males, New Zealand white rabbits were fed 2% high cholesterol diet. After six weeks, aortas were excised, opened longitudinally and stained with Sudan-IV for gross examination of atherosclerotic lesions. A total of 156 descending thoracic and 90 abdominal ostia were examined. Mean lesion frequencies upstream, downstream and at lateral margins of the affected ostia were calculated and compared. Sudanophilic lesions were detected around 32% ostia of descending thoracic aorta and 25% those of abdominal aorta. At ostia of descending thoracic aorta, lesion frequencies were significantly higher (P<0.001) downstream (95%) and at lateral margins (92%) than upstream (2%). In abdominal aorta, lateral (100%) and upstream (43%) margins were significantly (P<0.05) more affected while minimal lesion frequencies were seen at downstream branch points (9%). Comparison between descending thoracic and abdominal aorta showed an insignificant difference of lesion frequencies at lateral margins (P>0.05) but a highly significant difference at upstream versus downstream of ostia (P<0.001). We concluded that in cholesterol-fed adult rabbits, juvenile pattern of downstream lipid deposition persists at ostia of descending thoracic aorta while a switch towards the upstream pattern of old subjects occurs at ostia of abdominal aorta.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.3 20112011-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300013en10.4067/S0717-95022011000300013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sudanophilic lesions Aorta Ostia Rabbits
spellingShingle	Sudanophilic lesions Aorta Ostia Rabbits Shahid,Uzma Butt,Shadab Ahmed Zareen,Nusrat Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits
description	Sudan-positive atherosclerotic lesions preferentially occur at downstream and lateral margins of arterial branch ostia in human neonates and weanling rabbits but tend to develop at lateral and upstream margins in old subjects. We investigated (i) the pattern of sudanophilic lesions at aortic ostia of cholesterol-fed adult rabbits and (ii) determined any differences in lesion distribution between descending thoracic and abdominal aorta. Ten adult males, New Zealand white rabbits were fed 2% high cholesterol diet. After six weeks, aortas were excised, opened longitudinally and stained with Sudan-IV for gross examination of atherosclerotic lesions. A total of 156 descending thoracic and 90 abdominal ostia were examined. Mean lesion frequencies upstream, downstream and at lateral margins of the affected ostia were calculated and compared. Sudanophilic lesions were detected around 32% ostia of descending thoracic aorta and 25% those of abdominal aorta. At ostia of descending thoracic aorta, lesion frequencies were significantly higher (P<0.001) downstream (95%) and at lateral margins (92%) than upstream (2%). In abdominal aorta, lateral (100%) and upstream (43%) margins were significantly (P<0.05) more affected while minimal lesion frequencies were seen at downstream branch points (9%). Comparison between descending thoracic and abdominal aorta showed an insignificant difference of lesion frequencies at lateral margins (P>0.05) but a highly significant difference at upstream versus downstream of ostia (P<0.001). We concluded that in cholesterol-fed adult rabbits, juvenile pattern of downstream lipid deposition persists at ostia of descending thoracic aorta while a switch towards the upstream pattern of old subjects occurs at ostia of abdominal aorta.
author	Shahid,Uzma Butt,Shadab Ahmed Zareen,Nusrat
author_facet	Shahid,Uzma Butt,Shadab Ahmed Zareen,Nusrat
author_sort	Shahid,Uzma
title	Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits
title_short	Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits
title_full	Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits
title_fullStr	Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits
title_full_unstemmed	Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits
title_sort	patterns of sudanophilic lesions at ostia of descending thoracic and abdominal aorta in cholesterol-fed adult rabbits
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300013
work_keys_str_mv	AT shahiduzma patternsofsudanophiliclesionsatostiaofdescendingthoracicandabdominalaortaincholesterolfedadultrabbits AT buttshadabahmed patternsofsudanophiliclesionsatostiaofdescendingthoracicandabdominalaortaincholesterolfedadultrabbits AT zareennusrat patternsofsudanophiliclesionsatostiaofdescendingthoracicandabdominalaortaincholesterolfedadultrabbits
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Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits

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