Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice

Mentha piperita (Labiatae), commonly known as peppermint is a native Iranian herb which is used in folk medicine for various purposes. This study was carried out to reveal the teratogenic effect of Mentha piperita on mice fetuses. In this experimental study, pregnant Balb/c mice divided to four grou...

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Autores principales:	Golalipour,Mohammad Jafar, Ghafari,Soraya, Maleki,Alireza, Kiani,Mossa, Asadi,Ebrahim, Farsi,Mirmerhdad
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Mentha piperita Teratogen Bone ossification Developmental toxicity Mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300033
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spelling	oai:scielo:S0717-950220110003000332012-06-11Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c MiceGolalipour,Mohammad JafarGhafari,SorayaMaleki,AlirezaKiani,MossaAsadi,EbrahimFarsi,Mirmerhdad Mentha piperita Teratogen Bone ossification Developmental toxicity Mice Mentha piperita (Labiatae), commonly known as peppermint is a native Iranian herb which is used in folk medicine for various purposes. This study was carried out to reveal the teratogenic effect of Mentha piperita on mice fetuses. In this experimental study, pregnant Balb/c mice divided to four groups. Case group received 600 (treatment I) and 1200 (treatment II) mg/kg/day the hydroalcoholic extract of Mentha piperita during 6-15 of gestational days and one control group received normal saline during GD6-GD15 by gavages and other control group did not receive any matter during 6-15 of gestational days. Mice sacrificed at GD18 and embryos were collected. Macroscopic observation was done by stereomicroscope. 20 fetuses of each group were stained by Alizarin red-S and Alcian blue staining method. The Mean weight of fetuses decreased in treatment groups rather than control (P<0.05) but CRL there was no significant difference between treatments and controls groups. In the treatment I (600 mg/kg/day) and treatment II (1200 mg/kg/day), normal saline and control group, no gross congenital malformations were observed in fetuses. Treated fetuses also had no delayed bone ossification as determined by Alizarin red-S and Alcian blue staining method. This study showed that the hydroalcoholic extract of Mentha piperita (600 and 1200 mg/kg/day) has no teratogenic effect in mice fetuses if used continuously during embryonic period.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.3 20112011-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300033en10.4067/S0717-95022011000300033
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mentha piperita Teratogen Bone ossification Developmental toxicity Mice
spellingShingle	Mentha piperita Teratogen Bone ossification Developmental toxicity Mice Golalipour,Mohammad Jafar Ghafari,Soraya Maleki,Alireza Kiani,Mossa Asadi,Ebrahim Farsi,Mirmerhdad Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice
description	Mentha piperita (Labiatae), commonly known as peppermint is a native Iranian herb which is used in folk medicine for various purposes. This study was carried out to reveal the teratogenic effect of Mentha piperita on mice fetuses. In this experimental study, pregnant Balb/c mice divided to four groups. Case group received 600 (treatment I) and 1200 (treatment II) mg/kg/day the hydroalcoholic extract of Mentha piperita during 6-15 of gestational days and one control group received normal saline during GD6-GD15 by gavages and other control group did not receive any matter during 6-15 of gestational days. Mice sacrificed at GD18 and embryos were collected. Macroscopic observation was done by stereomicroscope. 20 fetuses of each group were stained by Alizarin red-S and Alcian blue staining method. The Mean weight of fetuses decreased in treatment groups rather than control (P<0.05) but CRL there was no significant difference between treatments and controls groups. In the treatment I (600 mg/kg/day) and treatment II (1200 mg/kg/day), normal saline and control group, no gross congenital malformations were observed in fetuses. Treated fetuses also had no delayed bone ossification as determined by Alizarin red-S and Alcian blue staining method. This study showed that the hydroalcoholic extract of Mentha piperita (600 and 1200 mg/kg/day) has no teratogenic effect in mice fetuses if used continuously during embryonic period.
author	Golalipour,Mohammad Jafar Ghafari,Soraya Maleki,Alireza Kiani,Mossa Asadi,Ebrahim Farsi,Mirmerhdad
author_facet	Golalipour,Mohammad Jafar Ghafari,Soraya Maleki,Alireza Kiani,Mossa Asadi,Ebrahim Farsi,Mirmerhdad
author_sort	Golalipour,Mohammad Jafar
title	Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice
title_short	Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice
title_full	Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice
title_fullStr	Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice
title_full_unstemmed	Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice
title_sort	study of embryotoxicity of mentha piperita l. during organogenesis in balb/c mice
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300033
work_keys_str_mv	AT golalipourmohammadjafar studyofembryotoxicityofmenthapiperitalduringorganogenesisinbalbcmice AT ghafarisoraya studyofembryotoxicityofmenthapiperitalduringorganogenesisinbalbcmice AT malekialireza studyofembryotoxicityofmenthapiperitalduringorganogenesisinbalbcmice AT kianimossa studyofembryotoxicityofmenthapiperitalduringorganogenesisinbalbcmice AT asadiebrahim studyofembryotoxicityofmenthapiperitalduringorganogenesisinbalbcmice AT farsimirmerhdad studyofembryotoxicityofmenthapiperitalduringorganogenesisinbalbcmice
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Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice

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