Stem Cells and Androgen Receptor in Human Periapical Periodontitis

Stem Cells and Androgen Receptor in Human Periapical Periodontitis

Activation of macrophages in periapical granulomas occurs through the presence of cytokines, endotoxin and other genetic and epigenetic factors, allowing the initiation of inflammation and bone resorption. The present study aims to analyze the presence of CD133 protein (marker of stem cells) and the...

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Autores principales: Rodríguez,H, Espinoza-Navarro,O, Peñafiel,C, Escobar,E, Silva,I, Quiroz,P, Arriaza,C, Castro,M. E, Sánchez,C, Arias,M, Michea,A
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2011
Materias:
Stem cell
Androgen receptor
Granuloma
Periodontitis
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300048
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spelling oai:scielo:S0717-950220110003000482012-06-11Stem Cells and Androgen Receptor in Human Periapical PeriodontitisRodríguez,HEspinoza-Navarro,OPeñafiel,CEscobar,ESilva,IQuiroz,PArriaza,CCastro,M. ESánchez,CArias,MMichea,A Stem cell Androgen receptor Granuloma Periodontitis Activation of macrophages in periapical granulomas occurs through the presence of cytokines, endotoxin and other genetic and epigenetic factors, allowing the initiation of inflammation and bone resorption. The present study aims to analyze the presence of CD133 protein (marker of stem cells) and the AR (androgen receptor) protein in biopsies of human odontogenic periapical granuloma. Biopsies from 14 adult male patients with diagnosis of periapical granuloma included in paraffin blocks were processed histologically to obtain 5-µm thick sections. Protein presence was detected and analyzed by immunohistochemistry of CD133 and AR. The quantification considered the number of positive cells in 0.17 mm2 random areas under the microscope using a 1000X objective. Both CD133 and AR proteins are expressed abundantly in cells in pathological periapical granulomas tissue. The number of cells expressing CD133 and AR shows a wide variation coefficient, so its variation is a particular feature for each individual. We concluded that in human odontogenic periapical granuloma there are abundant stem cells and cells expressing AR that may be important for the pathogenic inflammatory process.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.3 20112011-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300048en10.4067/S0717-95022011000300048
institution Scielo Chile
collection Scielo Chile
language English
topic Stem cell
Androgen receptor
Granuloma
Periodontitis
spellingShingle Stem cell
Androgen receptor
Granuloma
Periodontitis
Rodríguez,H
Espinoza-Navarro,O
Peñafiel,C
Escobar,E
Silva,I
Quiroz,P
Arriaza,C
Castro,M. E
Sánchez,C
Arias,M
Michea,A
Stem Cells and Androgen Receptor in Human Periapical Periodontitis
description Activation of macrophages in periapical granulomas occurs through the presence of cytokines, endotoxin and other genetic and epigenetic factors, allowing the initiation of inflammation and bone resorption. The present study aims to analyze the presence of CD133 protein (marker of stem cells) and the AR (androgen receptor) protein in biopsies of human odontogenic periapical granuloma. Biopsies from 14 adult male patients with diagnosis of periapical granuloma included in paraffin blocks were processed histologically to obtain 5-µm thick sections. Protein presence was detected and analyzed by immunohistochemistry of CD133 and AR. The quantification considered the number of positive cells in 0.17 mm2 random areas under the microscope using a 1000X objective. Both CD133 and AR proteins are expressed abundantly in cells in pathological periapical granulomas tissue. The number of cells expressing CD133 and AR shows a wide variation coefficient, so its variation is a particular feature for each individual. We concluded that in human odontogenic periapical granuloma there are abundant stem cells and cells expressing AR that may be important for the pathogenic inflammatory process.
author Rodríguez,H
Espinoza-Navarro,O
Peñafiel,C
Escobar,E
Silva,I
Quiroz,P
Arriaza,C
Castro,M. E
Sánchez,C
Arias,M
Michea,A
author_facet Rodríguez,H
Espinoza-Navarro,O
Peñafiel,C
Escobar,E
Silva,I
Quiroz,P
Arriaza,C
Castro,M. E
Sánchez,C
Arias,M
Michea,A
author_sort Rodríguez,H
title Stem Cells and Androgen Receptor in Human Periapical Periodontitis
title_short Stem Cells and Androgen Receptor in Human Periapical Periodontitis
title_full Stem Cells and Androgen Receptor in Human Periapical Periodontitis
title_fullStr Stem Cells and Androgen Receptor in Human Periapical Periodontitis
title_full_unstemmed Stem Cells and Androgen Receptor in Human Periapical Periodontitis
title_sort stem cells and androgen receptor in human periapical periodontitis
publisher Sociedad Chilena de Anatomía
publishDate 2011
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300048
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