Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate

The purpose of this study was to investigate the ultrastructural effects of lead on the kidney cortex of rats. Wistar Albino rats (180-200g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both grou...

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Autores principales:	Deveci,E, Söker,S, Baran,Ö, Tunik,S, Ayaz,E, Deveci,S
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Lead acetate Kidney cortex Ultrastructural changes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300067
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spelling	oai:scielo:S0717-950220110003000672012-06-11Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead AcetateDeveci,ESöker,SBaran,ÖTunik,SAyaz,EDeveci,S Lead acetate Kidney cortex Ultrastructural changes The purpose of this study was to investigate the ultrastructural effects of lead on the kidney cortex of rats. Wistar Albino rats (180-200g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were taken from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. The kidney tissue samples were prepared and analyzed by light and transmission electron microscopy. Cortical renal tubules show various degenerative changes with focal tubular necrosis invaded by inflammatory cells. The ultrastructural alterations found in lead acetate-treated rats were a diminution in the amount of filtration slits, increased fusion of foot processes in epithelial cells of the glomeruli, increase of lysosomal structures and pinocytic vesicles as well as large mitochondria in proximal tubule cells.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.3 20112011-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300067en10.4067/S0717-95022011000300067
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Lead acetate Kidney cortex Ultrastructural changes
spellingShingle	Lead acetate Kidney cortex Ultrastructural changes Deveci,E Söker,S Baran,Ö Tunik,S Ayaz,E Deveci,S Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate
description	The purpose of this study was to investigate the ultrastructural effects of lead on the kidney cortex of rats. Wistar Albino rats (180-200g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were taken from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. The kidney tissue samples were prepared and analyzed by light and transmission electron microscopy. Cortical renal tubules show various degenerative changes with focal tubular necrosis invaded by inflammatory cells. The ultrastructural alterations found in lead acetate-treated rats were a diminution in the amount of filtration slits, increased fusion of foot processes in epithelial cells of the glomeruli, increase of lysosomal structures and pinocytic vesicles as well as large mitochondria in proximal tubule cells.
author	Deveci,E Söker,S Baran,Ö Tunik,S Ayaz,E Deveci,S
author_facet	Deveci,E Söker,S Baran,Ö Tunik,S Ayaz,E Deveci,S
author_sort	Deveci,E
title	Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate
title_short	Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate
title_full	Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate
title_fullStr	Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate
title_full_unstemmed	Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate
title_sort	ultrastructural changes in the kidney cortex of rats treated with lead acetate
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300067
work_keys_str_mv	AT devecie ultrastructuralchangesinthekidneycortexofratstreatedwithleadacetate AT sokers ultrastructuralchangesinthekidneycortexofratstreatedwithleadacetate AT barano ultrastructuralchangesinthekidneycortexofratstreatedwithleadacetate AT tuniks ultrastructuralchangesinthekidneycortexofratstreatedwithleadacetate AT ayaze ultrastructuralchangesinthekidneycortexofratstreatedwithleadacetate AT devecis ultrastructuralchangesinthekidneycortexofratstreatedwithleadacetate
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Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate

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