Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

Ubiquitous consumption of Momordica charantia is hinged on credence of its potency in alleviating ailments. Almost no data exist on its quantitative relationship to the testes. The aim was to study the histomorphometric effect of Momordica charantia seed extract (MC), ascorbic acid (C), alpha-tocoph...

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Autores principales:	Yama,Oshiozokhai Eboetse, Duru,Francis Ikechukwu, Oremosu,Ademola Ayodele, Noronha,Cressie Carmel, Okanlawon,Abayomi
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Histomorphometric Momordica charantia Sprague-Dawley Testes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300068
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spelling	oai:scielo:S0717-950220110003000682012-06-11Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of RatYama,Oshiozokhai EboetseDuru,Francis IkechukwuOremosu,Ademola AyodeleNoronha,Cressie CarmelOkanlawon,Abayomi Histomorphometric Momordica charantia Sprague-Dawley Testes Ubiquitous consumption of Momordica charantia is hinged on credence of its potency in alleviating ailments. Almost no data exist on its quantitative relationship to the testes. The aim was to study the histomorphometric effect of Momordica charantia seed extract (MC), ascorbic acid (C), alpha-tocopherol (E) and testosterone (T) on the testes of rats. Ninety five mature 6-8 week-old male Sprague-Dawley (S-D) rats allotted randomly into six groups. Group I: fed MC for 16 weeks. Group II: administered MC for 8 weeks, later distilled water for another 8 weeks. Group III: administered C, E, T and a combination of all three test solutions (CET) for 8 weeks and later fed MC for another 8 weeks. Group IV: received MC initially for 8 weeks and later administered C, E, T and CET for another 8 weeks. Group V: fed concurrently the extract, C, E, T and CET for 8 weeks. Group VI (control): administered C, E, T, CET and distilled water for 16 weeks. The doses for MC, C, E and T were 50 mg/100 g b.w/oral/day, 0.01, 20.0 and 0.05 mg/kg. The animals were sacrificed; testes estimated for volume. Diameter, cross sectional area (AC), number of profiles per unit area (NA), length density (LV) and numerical density (NV) of the seminiferous tubules determined. The mean testicular volumes, tubular diameters and AC showed significant decline (p 0.05) in Groups I and III compared to controls. On cessation of MC values recovered to baseline control value. Groups IV and V, were not significantly (p 0.05) different from controls. There was a significant (p 0.05) increase in NA, LV and NV of seminiferous tubules in Groups I and III compared to controls. Histomorphometric data supports a reversible deleterious effect of MC on testes.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.3 20112011-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300068en10.4067/S0717-95022011000300068
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Histomorphometric Momordica charantia Sprague-Dawley Testes
spellingShingle	Histomorphometric Momordica charantia Sprague-Dawley Testes Yama,Oshiozokhai Eboetse Duru,Francis Ikechukwu Oremosu,Ademola Ayodele Noronha,Cressie Carmel Okanlawon,Abayomi Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat
description	Ubiquitous consumption of Momordica charantia is hinged on credence of its potency in alleviating ailments. Almost no data exist on its quantitative relationship to the testes. The aim was to study the histomorphometric effect of Momordica charantia seed extract (MC), ascorbic acid (C), alpha-tocopherol (E) and testosterone (T) on the testes of rats. Ninety five mature 6-8 week-old male Sprague-Dawley (S-D) rats allotted randomly into six groups. Group I: fed MC for 16 weeks. Group II: administered MC for 8 weeks, later distilled water for another 8 weeks. Group III: administered C, E, T and a combination of all three test solutions (CET) for 8 weeks and later fed MC for another 8 weeks. Group IV: received MC initially for 8 weeks and later administered C, E, T and CET for another 8 weeks. Group V: fed concurrently the extract, C, E, T and CET for 8 weeks. Group VI (control): administered C, E, T, CET and distilled water for 16 weeks. The doses for MC, C, E and T were 50 mg/100 g b.w/oral/day, 0.01, 20.0 and 0.05 mg/kg. The animals were sacrificed; testes estimated for volume. Diameter, cross sectional area (AC), number of profiles per unit area (NA), length density (LV) and numerical density (NV) of the seminiferous tubules determined. The mean testicular volumes, tubular diameters and AC showed significant decline (p 0.05) in Groups I and III compared to controls. On cessation of MC values recovered to baseline control value. Groups IV and V, were not significantly (p 0.05) different from controls. There was a significant (p 0.05) increase in NA, LV and NV of seminiferous tubules in Groups I and III compared to controls. Histomorphometric data supports a reversible deleterious effect of MC on testes.
author	Yama,Oshiozokhai Eboetse Duru,Francis Ikechukwu Oremosu,Ademola Ayodele Noronha,Cressie Carmel Okanlawon,Abayomi
author_facet	Yama,Oshiozokhai Eboetse Duru,Francis Ikechukwu Oremosu,Ademola Ayodele Noronha,Cressie Carmel Okanlawon,Abayomi
author_sort	Yama,Oshiozokhai Eboetse
title	Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat
title_short	Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat
title_full	Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat
title_fullStr	Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat
title_full_unstemmed	Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat
title_sort	stereological evaluation of the effects of momordica charantia, antioxidants and testosterone on seminiferous tubules of rat
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300068
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Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

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