The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in Goats

The morphometry of bronchial associated lymphoid tissue (BALT) and its possible exploration as to the control of common viral and bacterial pneumonia and their co-infection in Sub-Saharan goats is scanty in literatures. This investigation utilizes archival tissues from study that involved 35 apparen...

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Autores principales:	Emikpe,B. O, Ajisegiri,W. A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Morphometry Bronchial associated lymphoid tissue PPRV Mannheimia hemolytica Goats Experimental
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400004
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spelling	oai:scielo:S0717-950220110004000042012-07-30The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in GoatsEmikpe,B. OAjisegiri,W. A Morphometry Bronchial associated lymphoid tissue PPRV Mannheimia hemolytica Goats Experimental The morphometry of bronchial associated lymphoid tissue (BALT) and its possible exploration as to the control of common viral and bacterial pneumonia and their co-infection in Sub-Saharan goats is scanty in literatures. This investigation utilizes archival tissues from study that involved 35 apparently healthy West Africa Dwarf goats which were divided into groups PPRV and PPRV+MH with 15 goats each while 5 goats served as control. PPRV goats were infected intratracheally with 1ml of pure cultured 106.5 TCID50 PPR Pestes des petit Ruminant virus (PPRV) grown in baby hamster kidney cell lines and PPRV+MH with 1 ml of PPRV and a week later 1ml of MH (Mannheimia hemolytica) A2. The BALT number, type and cellularity were determined using standard methods with the use of an image analyzer. Student t-test was used to test for significant differences. The results showed that the average number of BALT was significantly more in PPRV+MH infection than that of PPRV infection i.e. 6.20±3.63 for PPRV+MH and 4.11±2.92 for PPRV with more nodular types of BALT (8.01±1.83) than the aggregates type (4.3±1.50) while the average number of lymphocytes in the nodular, aggregate BALT significantly increased with 82.25±15.95, 56.00±7.28 in PPRV to 103.33±44.10, 66.00±7.93 in PPRV+MH respectively. There was an irregular pattern in the surface Area (SA) and Perimeter (P) of BALT following infections. The increase in average number of BALT and lymphocytes in PPRV+MH infection than that of PPRV infection showed that the development of BALT and the number of lymphocytes in BALT could be used to assess the mucosal immunity following intratracheal administration of PPRV and MH in goats. This is however the first study that described the morphometry of bronchial associated lymphoid tissue in experimental PPRV and PPRV+MH infection in Sub-Saharan goats.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400004en10.4067/S0717-95022011000400004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Morphometry Bronchial associated lymphoid tissue PPRV Mannheimia hemolytica Goats Experimental
spellingShingle	Morphometry Bronchial associated lymphoid tissue PPRV Mannheimia hemolytica Goats Experimental Emikpe,B. O Ajisegiri,W. A The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in Goats
description	The morphometry of bronchial associated lymphoid tissue (BALT) and its possible exploration as to the control of common viral and bacterial pneumonia and their co-infection in Sub-Saharan goats is scanty in literatures. This investigation utilizes archival tissues from study that involved 35 apparently healthy West Africa Dwarf goats which were divided into groups PPRV and PPRV+MH with 15 goats each while 5 goats served as control. PPRV goats were infected intratracheally with 1ml of pure cultured 106.5 TCID50 PPR Pestes des petit Ruminant virus (PPRV) grown in baby hamster kidney cell lines and PPRV+MH with 1 ml of PPRV and a week later 1ml of MH (Mannheimia hemolytica) A2. The BALT number, type and cellularity were determined using standard methods with the use of an image analyzer. Student t-test was used to test for significant differences. The results showed that the average number of BALT was significantly more in PPRV+MH infection than that of PPRV infection i.e. 6.20±3.63 for PPRV+MH and 4.11±2.92 for PPRV with more nodular types of BALT (8.01±1.83) than the aggregates type (4.3±1.50) while the average number of lymphocytes in the nodular, aggregate BALT significantly increased with 82.25±15.95, 56.00±7.28 in PPRV to 103.33±44.10, 66.00±7.93 in PPRV+MH respectively. There was an irregular pattern in the surface Area (SA) and Perimeter (P) of BALT following infections. The increase in average number of BALT and lymphocytes in PPRV+MH infection than that of PPRV infection showed that the development of BALT and the number of lymphocytes in BALT could be used to assess the mucosal immunity following intratracheal administration of PPRV and MH in goats. This is however the first study that described the morphometry of bronchial associated lymphoid tissue in experimental PPRV and PPRV+MH infection in Sub-Saharan goats.
author	Emikpe,B. O Ajisegiri,W. A
author_facet	Emikpe,B. O Ajisegiri,W. A
author_sort	Emikpe,B. O
title	The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in Goats
title_short	The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in Goats
title_full	The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in Goats
title_fullStr	The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in Goats
title_full_unstemmed	The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in Goats
title_sort	response of bronchial associated lymphoid tissue to intratracheal administration of peste des petit ruminants virus and its co-infection with mannheimia hemolytica in goats
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400004
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The Response of Bronchial Associated Lymphoid Tissue to Intratracheal Administration of Peste des Petit Ruminants Virus and its Co-Infection with Mannheimia hemolytica in Goats

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