Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

An attempt to find out the male contraceptive molecule of plant origin, the extracts of seeds of Momordica charantia were tested in male mice. Petroleum ether, chloroform and ethanolic extracts of Momordica charantia were administered at the dose level of 25mg/100gm body weight to the albino mice fo...

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Autores principales:	Patil,Sharanabasappa A, Patil,Saraswati B
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Momordica charantia Linn Toxicological Androgenic Testis Spermatogenesis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400024
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spelling	oai:scielo:S0717-950220110004000242012-07-30Toxicological studies of Momordica charantia Linn Seed extracts in Male MicePatil,Sharanabasappa APatil,Saraswati B Momordica charantia Linn Toxicological Androgenic Testis Spermatogenesis An attempt to find out the male contraceptive molecule of plant origin, the extracts of seeds of Momordica charantia were tested in male mice. Petroleum ether, chloroform and ethanolic extracts of Momordica charantia were administered at the dose level of 25mg/100gm body weight to the albino mice for 48 days intraperitoneally. All the extracts showed antispermatogenic effect as the number of spermatogonia, spermatocytes, spermatids and spermatozoa were decreased. The increase in the weight of epididymis, prostate gland, seminal vesicle and vas deferens indicates clearly the androgenic property of these extracts. After subjecting to preliminary phytochemical screening ethanol extract showed positive tests for alkaloids, flavonoids, glycosides, phenols, tannins, oils and fats. Out of the three extracts tested, the ethanol extract seems to be more potent in its contraceptive and androgenic activities.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400024en10.4067/S0717-95022011000400024
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Momordica charantia Linn Toxicological Androgenic Testis Spermatogenesis
spellingShingle	Momordica charantia Linn Toxicological Androgenic Testis Spermatogenesis Patil,Sharanabasappa A Patil,Saraswati B Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice
description	An attempt to find out the male contraceptive molecule of plant origin, the extracts of seeds of Momordica charantia were tested in male mice. Petroleum ether, chloroform and ethanolic extracts of Momordica charantia were administered at the dose level of 25mg/100gm body weight to the albino mice for 48 days intraperitoneally. All the extracts showed antispermatogenic effect as the number of spermatogonia, spermatocytes, spermatids and spermatozoa were decreased. The increase in the weight of epididymis, prostate gland, seminal vesicle and vas deferens indicates clearly the androgenic property of these extracts. After subjecting to preliminary phytochemical screening ethanol extract showed positive tests for alkaloids, flavonoids, glycosides, phenols, tannins, oils and fats. Out of the three extracts tested, the ethanol extract seems to be more potent in its contraceptive and androgenic activities.
author	Patil,Sharanabasappa A Patil,Saraswati B
author_facet	Patil,Sharanabasappa A Patil,Saraswati B
author_sort	Patil,Sharanabasappa A
title	Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice
title_short	Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice
title_full	Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice
title_fullStr	Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice
title_full_unstemmed	Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice
title_sort	toxicological studies of momordica charantia linn seed extracts in male mice
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400024
work_keys_str_mv	AT patilsharanabasappaa toxicologicalstudiesofmomordicacharantialinnseedextractsinmalemice AT patilsaraswatib toxicologicalstudiesofmomordicacharantialinnseedextractsinmalemice
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Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

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