Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon

Since normal sperm parameters can be altered by organophosphorous pesticides, this study intended to determine if melatonin is able to prevent the damage on sperm quality after an acute exposure to diazinon. Adult male mice were injected intraperitoneally with melatonin, diazinon (1/3 or 2/3 LD50) o...

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Autores principales:	Sarabia,L, Espinoza-Navarro,O, Maurer,I, Ponce,C, Bustos-Obregón,E
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Melatonin Organophosphates Antioxidant Mouse sperm Sperm morphology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400029
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spelling	oai:scielo:S0717-950220110004000292012-07-30Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to DiazinonSarabia,LEspinoza-Navarro,OMaurer,IPonce,CBustos-Obregón,E Melatonin Organophosphates Antioxidant Mouse sperm Sperm morphology Since normal sperm parameters can be altered by organophosphorous pesticides, this study intended to determine if melatonin is able to prevent the damage on sperm quality after an acute exposure to diazinon. Adult male mice were injected intraperitoneally with melatonin, diazinon (1/3 or 2/3 LD50) or both, and sperm parameters were evaluated on days 1 or 32 post injection. Groups treated with diazinon showed elevated lipid peroxidation levels on day 1 post treatment, while groups pretreated with melatonin before diazinon showed no difference compared to control. Sperm count showed a significant decrease in both diazinon-treated groups only on day 32 post injection; no differences were observed in groups pretreated with melatonin prior to diazinon compared to control. The percentage of abnormal sperm morphology increased in the diazinon-treated groups only on day 32 postinjection. The administration of melatonin prior to exposure to diazinon prevents the alteration of sperm parameters commonly caused by organophosphates, possibly due to its antioxidant properties.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400029en10.4067/S0717-95022011000400029
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Melatonin Organophosphates Antioxidant Mouse sperm Sperm morphology
spellingShingle	Melatonin Organophosphates Antioxidant Mouse sperm Sperm morphology Sarabia,L Espinoza-Navarro,O Maurer,I Ponce,C Bustos-Obregón,E Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon
description	Since normal sperm parameters can be altered by organophosphorous pesticides, this study intended to determine if melatonin is able to prevent the damage on sperm quality after an acute exposure to diazinon. Adult male mice were injected intraperitoneally with melatonin, diazinon (1/3 or 2/3 LD50) or both, and sperm parameters were evaluated on days 1 or 32 post injection. Groups treated with diazinon showed elevated lipid peroxidation levels on day 1 post treatment, while groups pretreated with melatonin before diazinon showed no difference compared to control. Sperm count showed a significant decrease in both diazinon-treated groups only on day 32 post injection; no differences were observed in groups pretreated with melatonin prior to diazinon compared to control. The percentage of abnormal sperm morphology increased in the diazinon-treated groups only on day 32 postinjection. The administration of melatonin prior to exposure to diazinon prevents the alteration of sperm parameters commonly caused by organophosphates, possibly due to its antioxidant properties.
author	Sarabia,L Espinoza-Navarro,O Maurer,I Ponce,C Bustos-Obregón,E
author_facet	Sarabia,L Espinoza-Navarro,O Maurer,I Ponce,C Bustos-Obregón,E
author_sort	Sarabia,L
title	Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon
title_short	Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon
title_full	Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon
title_fullStr	Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon
title_full_unstemmed	Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon
title_sort	protective effect of melatonin on damage in the sperm parameters of mice exposed to diazinon
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400029
work_keys_str_mv	AT sarabial protectiveeffectofmelatoninondamageinthespermparametersofmiceexposedtodiazinon AT espinozanavarroo protectiveeffectofmelatoninondamageinthespermparametersofmiceexposedtodiazinon AT maureri protectiveeffectofmelatoninondamageinthespermparametersofmiceexposedtodiazinon AT poncec protectiveeffectofmelatoninondamageinthespermparametersofmiceexposedtodiazinon AT bustosobregone protectiveeffectofmelatoninondamageinthespermparametersofmiceexposedtodiazinon
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Protective Effect of Melatonin on Damage in the Sperm Parameters of Mice Exposed to Diazinon

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