Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological Study

Testicular torsion is a disorder involving the scrotum that results in a compromise of its blood supply. The aim was to investigate the effect of Pausinystallia macroceras (PM) on testicular histology following torsion-detortion at different time intervals ranging from 1 to 4 hours 65 mature male Wi...

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Autores principales:	Ikebuaso,A. D, Yama,O. E, Amah,C. I, Oremosu,A. A, Duru,F. I. O, Oyebadejo,S. A, Noronha,C. C, Okanlawon,A. O, Mojekwu,T. O
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Pausinystallia macroceras Torsion-Detortion Wister rats Testes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400031
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spelling	oai:scielo:S0717-950220110004000312012-07-30Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological StudyIkebuaso,A. DYama,O. EAmah,C. IOremosu,A. ADuru,F. I. OOyebadejo,S. ANoronha,C. COkanlawon,A. OMojekwu,T. O Pausinystallia macroceras Torsion-Detortion Wister rats Testes Testicular torsion is a disorder involving the scrotum that results in a compromise of its blood supply. The aim was to investigate the effect of Pausinystallia macroceras (PM) on testicular histology following torsion-detortion at different time intervals ranging from 1 to 4 hours 65 mature male Wister rats allotted randomly into seven groups (A to G; E& F further divided into 4-subgroups). Each group/subgroup comprised 5 rats. Testis maintained in the torted position (T) for 1, 2, 3 and 4 hours in Groups A (AT1+PM), B (BT2+PM), C (CT3+PM) and D (DT4+PM). Group E subgroups (E1+PM, E2+PM, E3+PM, E4+PM -) were sham operated, without torsion served as the sham control. Group F subgroups (F1T1, F2T2, F3T3 and F4T4) were torted as in A. All animals (except groups F & G) treated with PM extract (0.1 g/kg.b.w/day) for 56 days. Group G rats (normal control). Testes processed for histological studies. In AT1+PM showed preserved seminiferous tubules. BT2+PM, revealed varying number of necrosed and apoptotic seminiferous tubules. Group CT3+PM rats were similar to BT2+PM although with a slightly higher proportion of seminiferous tubules had undergone necrosis. In DT4+PM, sections showed few viable spermatozoa within the seminiferous tubules. When compared to the torted group F; showed extensive areas of seminiferous tubular necrosis (F3T3) as well as damage to the interstitium; while in F4T4 there were no viable testicular tissues seen. In conclusion, PM significantly prevented the cellular changes and cell death observed especially in group AT1+PM and BT2+PM.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400031en10.4067/S0717-95022011000400031
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Pausinystallia macroceras Torsion-Detortion Wister rats Testes
spellingShingle	Pausinystallia macroceras Torsion-Detortion Wister rats Testes Ikebuaso,A. D Yama,O. E Amah,C. I Oremosu,A. A Duru,F. I. O Oyebadejo,S. A Noronha,C. C Okanlawon,A. O Mojekwu,T. O Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological Study
description	Testicular torsion is a disorder involving the scrotum that results in a compromise of its blood supply. The aim was to investigate the effect of Pausinystallia macroceras (PM) on testicular histology following torsion-detortion at different time intervals ranging from 1 to 4 hours 65 mature male Wister rats allotted randomly into seven groups (A to G; E& F further divided into 4-subgroups). Each group/subgroup comprised 5 rats. Testis maintained in the torted position (T) for 1, 2, 3 and 4 hours in Groups A (AT1+PM), B (BT2+PM), C (CT3+PM) and D (DT4+PM). Group E subgroups (E1+PM, E2+PM, E3+PM, E4+PM -) were sham operated, without torsion served as the sham control. Group F subgroups (F1T1, F2T2, F3T3 and F4T4) were torted as in A. All animals (except groups F & G) treated with PM extract (0.1 g/kg.b.w/day) for 56 days. Group G rats (normal control). Testes processed for histological studies. In AT1+PM showed preserved seminiferous tubules. BT2+PM, revealed varying number of necrosed and apoptotic seminiferous tubules. Group CT3+PM rats were similar to BT2+PM although with a slightly higher proportion of seminiferous tubules had undergone necrosis. In DT4+PM, sections showed few viable spermatozoa within the seminiferous tubules. When compared to the torted group F; showed extensive areas of seminiferous tubular necrosis (F3T3) as well as damage to the interstitium; while in F4T4 there were no viable testicular tissues seen. In conclusion, PM significantly prevented the cellular changes and cell death observed especially in group AT1+PM and BT2+PM.
author	Ikebuaso,A. D Yama,O. E Amah,C. I Oremosu,A. A Duru,F. I. O Oyebadejo,S. A Noronha,C. C Okanlawon,A. O Mojekwu,T. O
author_facet	Ikebuaso,A. D Yama,O. E Amah,C. I Oremosu,A. A Duru,F. I. O Oyebadejo,S. A Noronha,C. C Okanlawon,A. O Mojekwu,T. O
author_sort	Ikebuaso,A. D
title	Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological Study
title_short	Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological Study
title_full	Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological Study
title_fullStr	Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological Study
title_full_unstemmed	Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological Study
title_sort	palliative effect of pausinystallia macroceras on testicular ischemic reperfusion injury in wistar rats: a histological study
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400031
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Palliative Effect of Pausinystallia macroceras on Testicular Ischemic Reperfusion Injury in Wistar Rats: a Histological Study

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