Vertebral Column Deformity and Hypoxia in Salmo salar

Vertebral Column Deformity (VCD) is a common pathology in Chilean salmon farms, lowering the quality and commercialization of the product. Hypoxia has been related to other musculoskeletal deformities, but not to VCD. This work analyzes the morphology of the vertebral column of Salmo salar alevins,...

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Autores principales:	Castro Sánchez,Rodrigo, Bustos Obregón,Eduardo, Rojas Rauco,Mariana
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Vertebral Column Deformity Hypoxia Salmon
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400036
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spelling	oai:scielo:S0717-950220110004000362012-07-30Vertebral Column Deformity and Hypoxia in Salmo salarCastro Sánchez,RodrigoBustos Obregón,EduardoRojas Rauco,Mariana Vertebral Column Deformity Hypoxia Salmon Vertebral Column Deformity (VCD) is a common pathology in Chilean salmon farms, lowering the quality and commercialization of the product. Hypoxia has been related to other musculoskeletal deformities, but not to VCD. This work analyzes the morphology of the vertebral column of Salmo salar alevins, cultured under hypoxic conditions (60% O2 saturation in the water tanks) for different time periods after hatching (2, 4, 6 and 8 days). They are compared with their normoxic controls (100% O2 saturation). Using histological (H/E), and morphometric techniques, it was found that the time of exposure to hypoxia is inversely proportional to the body length, notochordal diameter and thickness of its sheath. The organic response to hypoxia was quantified by immunohistochemistry for HIF-1a as the sensor of hypoxia. Its expression increased significantly (p<0.05) in the experimental groups that exhibit VCD. Although etiology for VCD is probably multifactorial, this study allows for the conclusion that hypoxia by itself, produces VCD.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400036en10.4067/S0717-95022011000400036
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Vertebral Column Deformity Hypoxia Salmon
spellingShingle	Vertebral Column Deformity Hypoxia Salmon Castro Sánchez,Rodrigo Bustos Obregón,Eduardo Rojas Rauco,Mariana Vertebral Column Deformity and Hypoxia in Salmo salar
description	Vertebral Column Deformity (VCD) is a common pathology in Chilean salmon farms, lowering the quality and commercialization of the product. Hypoxia has been related to other musculoskeletal deformities, but not to VCD. This work analyzes the morphology of the vertebral column of Salmo salar alevins, cultured under hypoxic conditions (60% O2 saturation in the water tanks) for different time periods after hatching (2, 4, 6 and 8 days). They are compared with their normoxic controls (100% O2 saturation). Using histological (H/E), and morphometric techniques, it was found that the time of exposure to hypoxia is inversely proportional to the body length, notochordal diameter and thickness of its sheath. The organic response to hypoxia was quantified by immunohistochemistry for HIF-1a as the sensor of hypoxia. Its expression increased significantly (p<0.05) in the experimental groups that exhibit VCD. Although etiology for VCD is probably multifactorial, this study allows for the conclusion that hypoxia by itself, produces VCD.
author	Castro Sánchez,Rodrigo Bustos Obregón,Eduardo Rojas Rauco,Mariana
author_facet	Castro Sánchez,Rodrigo Bustos Obregón,Eduardo Rojas Rauco,Mariana
author_sort	Castro Sánchez,Rodrigo
title	Vertebral Column Deformity and Hypoxia in Salmo salar
title_short	Vertebral Column Deformity and Hypoxia in Salmo salar
title_full	Vertebral Column Deformity and Hypoxia in Salmo salar
title_fullStr	Vertebral Column Deformity and Hypoxia in Salmo salar
title_full_unstemmed	Vertebral Column Deformity and Hypoxia in Salmo salar
title_sort	vertebral column deformity and hypoxia in salmo salar
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400036
work_keys_str_mv	AT castrosanchezrodrigo vertebralcolumndeformityandhypoxiainsalmosalar AT bustosobregoneduardo vertebralcolumndeformityandhypoxiainsalmosalar AT rojasraucomariana vertebralcolumndeformityandhypoxiainsalmosalar
_version_	1718444756187480064

Vertebral Column Deformity and Hypoxia in Salmo salar

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