Frequency of Common Variants in Genes Involved in Lipid-Lowering Response to Statins in Chilean Subjects with Hypercholesterolemia

Frequency of Common Variants in Genes Involved in Lipid-Lowering Response to Statins in Chilean Subjects with Hypercholesterolemia

Interindividual differences in activity and expression of the metabolizing enzymes cytochrome P450 (CYP) 3A4 and 3A5 and the multidrug efflux pump P-glycoprotein (P-gp, encoded by ABCB1 gene) contribute considerably to lipid-lowering efficacy of statin treatment in subjects with hypercholesterolemia...

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Autores principales: Rosales,Alexy, Pacheco,Alejandro, Cuevas,Alejandro, Saavedra,Nicolás, Zambrano,Tomás, Lanas,Fernando, Salazar,Luis A
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2011
Materias:
Polymorphisms
Statins
Hypercholesterolemia
ABCB1
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400037
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