Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the den...

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Autores principales:	Golalipour,Mohammad Jafar, Ghafari,Soraya, Latifimoghadam,Mohammad Hossein, Kaboli,Sakineh
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Diabetes Astrocyte Urtica dioica Dentate gyrus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400039
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spelling	oai:scielo:S0717-950220110004000392012-07-30Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioicaGolalipour,Mohammad JafarGhafari,SorayaLatifimoghadam,Mohammad HosseinKaboli,Sakineh Diabetes Astrocyte Urtica dioica Dentate gyrus Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days intraperitoneally. Four weeks after induction of diabetes, animals were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH stain. The area densities of the astrocytes were measured and compared in the three groups (p < 0.05). The number of astrocytes in DG area of controls was 17.72±6.7. The density of astrocytes increased in diabetic (24.26±9.5) in comparison with controls. The density in the nettle treated rats (23.17±5.8) was lower than diabetic rats. This study showed that the administration of U. dioica extract before induction of diabetes can not significantly help compensate for astrocytes in the dentate gyrus of treated rats.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400039en10.4067/S0717-95022011000400039
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes Astrocyte Urtica dioica Dentate gyrus
spellingShingle	Diabetes Astrocyte Urtica dioica Dentate gyrus Golalipour,Mohammad Jafar Ghafari,Soraya Latifimoghadam,Mohammad Hossein Kaboli,Sakineh Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica
description	Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days intraperitoneally. Four weeks after induction of diabetes, animals were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH stain. The area densities of the astrocytes were measured and compared in the three groups (p < 0.05). The number of astrocytes in DG area of controls was 17.72±6.7. The density of astrocytes increased in diabetic (24.26±9.5) in comparison with controls. The density in the nettle treated rats (23.17±5.8) was lower than diabetic rats. This study showed that the administration of U. dioica extract before induction of diabetes can not significantly help compensate for astrocytes in the dentate gyrus of treated rats.
author	Golalipour,Mohammad Jafar Ghafari,Soraya Latifimoghadam,Mohammad Hossein Kaboli,Sakineh
author_facet	Golalipour,Mohammad Jafar Ghafari,Soraya Latifimoghadam,Mohammad Hossein Kaboli,Sakineh
author_sort	Golalipour,Mohammad Jafar
title	Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica
title_short	Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica
title_full	Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica
title_fullStr	Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica
title_full_unstemmed	Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica
title_sort	alteration of dentate gyrus astrocytes in diabetic rats: protective role of urtica dioica
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400039
work_keys_str_mv	AT golalipourmohammadjafar alterationofdentategyrusastrocytesindiabeticratsprotectiveroleofurticadioica AT ghafarisoraya alterationofdentategyrusastrocytesindiabeticratsprotectiveroleofurticadioica AT latifimoghadammohammadhossein alterationofdentategyrusastrocytesindiabeticratsprotectiveroleofurticadioica AT kabolisakineh alterationofdentategyrusastrocytesindiabeticratsprotectiveroleofurticadioica
_version_	1718444756717010944

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

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