Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice

Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. The aim of this study was to verify the possible protective an...

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Autores principales:	De Souza,Paula Aiello Tomé, Marques,Maria Júlia, Lima,Clélia Akiko Hiruma, Matheus,Selma Maria Michelin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Muscle fiber Duchenne muscular dystrophy Citrus aurantium L mdx mouse Muscle regeneration Central nuclei Creatine kinase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400048
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spelling	oai:scielo:S0717-950220110004000482012-07-30Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx MiceDe Souza,Paula Aiello ToméMarques,Maria JúliaLima,Clélia Akiko HirumaMatheus,Selma Maria Michelin Muscle fiber Duchenne muscular dystrophy Citrus aurantium L mdx mouse Muscle regeneration Central nuclei Creatine kinase Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Thus, adult male and female mdx mice (014/06-CEEA) were divided into control and citrus-treated. After 60 days of treatment, one ml of blood was collected for creatine kinase (CK) test. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed and processed according to histological routine methods. The observed alterations indicate a direct effect of citrus. Recent studies have improved the diagnosis of muscular diseases but with no definitions of efficient treatments. Intervention with several therapies is important to many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no development of gene therapies.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400048en10.4067/S0717-95022011000400048
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Muscle fiber Duchenne muscular dystrophy Citrus aurantium L mdx mouse Muscle regeneration Central nuclei Creatine kinase
spellingShingle	Muscle fiber Duchenne muscular dystrophy Citrus aurantium L mdx mouse Muscle regeneration Central nuclei Creatine kinase De Souza,Paula Aiello Tomé Marques,Maria Júlia Lima,Clélia Akiko Hiruma Matheus,Selma Maria Michelin Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice
description	Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Thus, adult male and female mdx mice (014/06-CEEA) were divided into control and citrus-treated. After 60 days of treatment, one ml of blood was collected for creatine kinase (CK) test. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed and processed according to histological routine methods. The observed alterations indicate a direct effect of citrus. Recent studies have improved the diagnosis of muscular diseases but with no definitions of efficient treatments. Intervention with several therapies is important to many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no development of gene therapies.
author	De Souza,Paula Aiello Tomé Marques,Maria Júlia Lima,Clélia Akiko Hiruma Matheus,Selma Maria Michelin
author_facet	De Souza,Paula Aiello Tomé Marques,Maria Júlia Lima,Clélia Akiko Hiruma Matheus,Selma Maria Michelin
author_sort	De Souza,Paula Aiello Tomé
title	Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice
title_short	Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice
title_full	Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice
title_fullStr	Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice
title_full_unstemmed	Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice
title_sort	effect of citrus aurantium l. essential oil on muscle regeneration in mdx mice
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400048
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Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice

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