Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)

Persea americana (avocado) is widely grown in parts of Southeastern Nigeria and used as a medicinal plant in the treatment of several ailments by alternative medical practitioners but very little research has been carried out on its pharmacotoxicity. This study therefore intends to study the histopa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Adisa,J. O, Ajayi,Y, Egbujo,E. C
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Persea Americana Liver Kidney Histopathology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400053
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022011000400053
record_format	dspace
spelling	oai:scielo:S0717-950220110004000532012-07-30Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)Adisa,J. OAjayi,YEgbujo,E. C Persea Americana Liver Kidney Histopathology Persea americana (avocado) is widely grown in parts of Southeastern Nigeria and used as a medicinal plant in the treatment of several ailments by alternative medical practitioners but very little research has been carried out on its pharmacotoxicity. This study therefore intends to study the histopathologic effect(s) of Persea americana aqueous leaf extract on the liver and kidneys of rabbits. Fresh leaves of Persea americana were processed using the Soxhlet extraction to obtain the aqueous extract. Three (3) groups of weaner rabbits namely the control, the recommended dose and the high dose groups were given water, 75mg/kg/ and 150mg/kg per day of the extract respectively for 28 days. The animals were sacrificed, the liver and kidney were harvested, fixed in 10% buffered formol saline, processed into paraffin wax, sectioned at 5µm and stained by the Haematoxylin and Eosin method and Perl's Prussain Blue method. Slightly better weight gain by the experimental groups suggests that the extract enhances appetite. Histopathology of the liver and kidney of the recommended and high dosage groups were not different from the control group suggesting that the plant extract is beneficial except for the observed loose stool, suggesting increased bowel emptying. This however did not affect weight gain.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400053en10.4067/S0717-95022011000400053
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Persea Americana Liver Kidney Histopathology
spellingShingle	Persea Americana Liver Kidney Histopathology Adisa,J. O Ajayi,Y Egbujo,E. C Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)
description	Persea americana (avocado) is widely grown in parts of Southeastern Nigeria and used as a medicinal plant in the treatment of several ailments by alternative medical practitioners but very little research has been carried out on its pharmacotoxicity. This study therefore intends to study the histopathologic effect(s) of Persea americana aqueous leaf extract on the liver and kidneys of rabbits. Fresh leaves of Persea americana were processed using the Soxhlet extraction to obtain the aqueous extract. Three (3) groups of weaner rabbits namely the control, the recommended dose and the high dose groups were given water, 75mg/kg/ and 150mg/kg per day of the extract respectively for 28 days. The animals were sacrificed, the liver and kidney were harvested, fixed in 10% buffered formol saline, processed into paraffin wax, sectioned at 5µm and stained by the Haematoxylin and Eosin method and Perl's Prussain Blue method. Slightly better weight gain by the experimental groups suggests that the extract enhances appetite. Histopathology of the liver and kidney of the recommended and high dosage groups were not different from the control group suggesting that the plant extract is beneficial except for the observed loose stool, suggesting increased bowel emptying. This however did not affect weight gain.
author	Adisa,J. O Ajayi,Y Egbujo,E. C
author_facet	Adisa,J. O Ajayi,Y Egbujo,E. C
author_sort	Adisa,J. O
title	Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)
title_short	Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)
title_full	Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)
title_fullStr	Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)
title_full_unstemmed	Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)
title_sort	histopathologic effect of persea americana aqueous leaves extract on the liver and kidney of weaner rabbits (california species)
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400053
work_keys_str_mv	AT adisajo histopathologiceffectofperseaamericanaaqueousleavesextractontheliverandkidneyofweanerrabbitscaliforniaspecies AT ajayiy histopathologiceffectofperseaamericanaaqueousleavesextractontheliverandkidneyofweanerrabbitscaliforniaspecies AT egbujoec histopathologiceffectofperseaamericanaaqueousleavesextractontheliverandkidneyofweanerrabbitscaliforniaspecies
_version_	1718444759337402368

Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)

Ejemplares similares